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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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2014-February Volume 7 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Helicobacter pylori and gastrointestinal symptoms in diagnostics and adjuvant chemotherapy of colorectal cancer

  • Authors:
    • Leena‑Maija Soveri
    • Pia Österlund
    • Tarja Ruotsalainen
    • Tuija Poussa
    • Hilpi Rautelin
    • Petri Bono
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Helsinki University Central Hospital, Helsinki 00029, Finland, STAT‑Consulting, Nokia 37130, Finland, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki 00014, Finland
  • Pages: 553-559
    |
    Published online on: November 29, 2013
       https://doi.org/10.3892/ol.2013.1714
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Abstract

5‑Fluorouracil (5‑FU)‑based chemotherapy is the mainstay of adjuvant treatment for colorectal cancer (CRC). Few studies have explored Helicobacter pylori (H. pylori)‑associated gastrointestinal symptoms in the diagnosis of CRC, and the association between H. pylori infection and gastrointestinal toxicity during adjuvant chemotherapy in CRC. Seventy‑nine CRC patients were randomised in a prospective clinical trial to receive 5‑FU and leucovorin administered as bolus injection (Mayo regimen) or continuous infusion (simplified de Gramont regimen). H. pylori antibodies were analysed at baseline, twice monthly during treatment and after treatment up to 12 months. Thirty‑seven patients (47%) were H. pylori‑seronegative at baseline. There was no significant association between baseline H. pylori seropositivity (n=42; 53%) and oro‑gastrointestinal toxicity during chemotherapy. The median time from symptom onset of CRC to surgery was significantly longer in patients with H. pylori infection (median time, 6 vs. 5 months; P=0.012). Functional dyspeptic symptoms at presentation significantly delayed diagnosis (median time, 7.5 vs. 5 months; P=0.035), whereas anaemia, bowel symptoms, occlusion, blood in the stool, infection and hypolactasia did not. We conclude that there is no association between H. pylori status and gastrointestinal toxicity in CRC patients during chemotherapy. Dyspeptic symptoms and presence of H. pylori may delay the diagnosis of CRC. (www.controlled‑trials.com/ISRCTN98405441).
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Copy and paste a formatted citation
Spandidos Publications style
Soveri LM, Österlund P, Ruotsalainen T, Poussa T, Rautelin H and Bono P: Helicobacter pylori and gastrointestinal symptoms in diagnostics and adjuvant chemotherapy of colorectal cancer. Oncol Lett 7: 553-559, 2014.
APA
Soveri, L., Österlund, P., Ruotsalainen, T., Poussa, T., Rautelin, H., & Bono, P. (2014). Helicobacter pylori and gastrointestinal symptoms in diagnostics and adjuvant chemotherapy of colorectal cancer. Oncology Letters, 7, 553-559. https://doi.org/10.3892/ol.2013.1714
MLA
Soveri, L., Österlund, P., Ruotsalainen, T., Poussa, T., Rautelin, H., Bono, P."Helicobacter pylori and gastrointestinal symptoms in diagnostics and adjuvant chemotherapy of colorectal cancer". Oncology Letters 7.2 (2014): 553-559.
Chicago
Soveri, L., Österlund, P., Ruotsalainen, T., Poussa, T., Rautelin, H., Bono, P."Helicobacter pylori and gastrointestinal symptoms in diagnostics and adjuvant chemotherapy of colorectal cancer". Oncology Letters 7, no. 2 (2014): 553-559. https://doi.org/10.3892/ol.2013.1714
Copy and paste a formatted citation
x
Spandidos Publications style
Soveri LM, Österlund P, Ruotsalainen T, Poussa T, Rautelin H and Bono P: Helicobacter pylori and gastrointestinal symptoms in diagnostics and adjuvant chemotherapy of colorectal cancer. Oncol Lett 7: 553-559, 2014.
APA
Soveri, L., Österlund, P., Ruotsalainen, T., Poussa, T., Rautelin, H., & Bono, P. (2014). Helicobacter pylori and gastrointestinal symptoms in diagnostics and adjuvant chemotherapy of colorectal cancer. Oncology Letters, 7, 553-559. https://doi.org/10.3892/ol.2013.1714
MLA
Soveri, L., Österlund, P., Ruotsalainen, T., Poussa, T., Rautelin, H., Bono, P."Helicobacter pylori and gastrointestinal symptoms in diagnostics and adjuvant chemotherapy of colorectal cancer". Oncology Letters 7.2 (2014): 553-559.
Chicago
Soveri, L., Österlund, P., Ruotsalainen, T., Poussa, T., Rautelin, H., Bono, P."Helicobacter pylori and gastrointestinal symptoms in diagnostics and adjuvant chemotherapy of colorectal cancer". Oncology Letters 7, no. 2 (2014): 553-559. https://doi.org/10.3892/ol.2013.1714
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