Metastasis‑associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells

  • Authors:
    • Haili Zhang
    • Dong Yang
    • Haijuan Wang
    • Shuxin Wen
    • Jian Liu
    • Qingchun Luan
    • Yixuan Huang
    • Binquan Wang
    • Chen Lin
    • Haili Qian
  • View Affiliations

  • Published online on: December 5, 2013     https://doi.org/10.3892/ol.2013.1729
  • Pages: 399-404
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Abstract

Overexpression of the metastasis‑associated gene 1 (MTA1) has previously been found to be associated with progression of various cancer types to the metastasis stage. The function of MTA1 in laryngeal squamous cell carcinoma (LSCC) remains unclear. To explore the significance of MTA1 in the invasion and migration processes in LSCC, gene transfection and RNA interference (RNAi) were performed to study the biological function of MTA1 in the LSCC cell line, HEP‑2. Results showed that MTA1 promoted the invasion, adhesion and migration behavior of LSCC cells. RNAi against MTA1 significantly decreased the malignant phenotypes of cancer cells. MTA1 may be important in the process of LSCC invasion and metastasis.
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2014-February
Volume 7 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang H, Yang D, Wang H, Wen S, Liu J, Luan Q, Huang Y, Wang B, Lin C, Qian H, Qian H, et al: Metastasis‑associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells. Oncol Lett 7: 399-404, 2014
APA
Zhang, H., Yang, D., Wang, H., Wen, S., Liu, J., Luan, Q. ... Qian, H. (2014). Metastasis‑associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells. Oncology Letters, 7, 399-404. https://doi.org/10.3892/ol.2013.1729
MLA
Zhang, H., Yang, D., Wang, H., Wen, S., Liu, J., Luan, Q., Huang, Y., Wang, B., Lin, C., Qian, H."Metastasis‑associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells". Oncology Letters 7.2 (2014): 399-404.
Chicago
Zhang, H., Yang, D., Wang, H., Wen, S., Liu, J., Luan, Q., Huang, Y., Wang, B., Lin, C., Qian, H."Metastasis‑associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells". Oncology Letters 7, no. 2 (2014): 399-404. https://doi.org/10.3892/ol.2013.1729