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Article

Metastasis‑associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells

  • Authors:
    • Haili Zhang
    • Dong Yang
    • Haijuan Wang
    • Shuxin Wen
    • Jian Liu
    • Qingchun Luan
    • Yixuan Huang
    • Binquan Wang
    • Chen Lin
    • Haili Qian
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology Head and Neck Surgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China, State Key Laboratory of Molecular Oncology, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chao Yang, Beijing 100021, P.R. China
  • Pages: 399-404
    |
    Published online on: December 5, 2013
       https://doi.org/10.3892/ol.2013.1729
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Abstract

Overexpression of the metastasis‑associated gene 1 (MTA1) has previously been found to be associated with progression of various cancer types to the metastasis stage. The function of MTA1 in laryngeal squamous cell carcinoma (LSCC) remains unclear. To explore the significance of MTA1 in the invasion and migration processes in LSCC, gene transfection and RNA interference (RNAi) were performed to study the biological function of MTA1 in the LSCC cell line, HEP‑2. Results showed that MTA1 promoted the invasion, adhesion and migration behavior of LSCC cells. RNAi against MTA1 significantly decreased the malignant phenotypes of cancer cells. MTA1 may be important in the process of LSCC invasion and metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Yang D, Wang H, Wen S, Liu J, Luan Q, Huang Y, Wang B, Lin C, Qian H, Qian H, et al: Metastasis‑associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells. Oncol Lett 7: 399-404, 2014.
APA
Zhang, H., Yang, D., Wang, H., Wen, S., Liu, J., Luan, Q. ... Qian, H. (2014). Metastasis‑associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells. Oncology Letters, 7, 399-404. https://doi.org/10.3892/ol.2013.1729
MLA
Zhang, H., Yang, D., Wang, H., Wen, S., Liu, J., Luan, Q., Huang, Y., Wang, B., Lin, C., Qian, H."Metastasis‑associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells". Oncology Letters 7.2 (2014): 399-404.
Chicago
Zhang, H., Yang, D., Wang, H., Wen, S., Liu, J., Luan, Q., Huang, Y., Wang, B., Lin, C., Qian, H."Metastasis‑associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells". Oncology Letters 7, no. 2 (2014): 399-404. https://doi.org/10.3892/ol.2013.1729
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang H, Yang D, Wang H, Wen S, Liu J, Luan Q, Huang Y, Wang B, Lin C, Qian H, Qian H, et al: Metastasis‑associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells. Oncol Lett 7: 399-404, 2014.
APA
Zhang, H., Yang, D., Wang, H., Wen, S., Liu, J., Luan, Q. ... Qian, H. (2014). Metastasis‑associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells. Oncology Letters, 7, 399-404. https://doi.org/10.3892/ol.2013.1729
MLA
Zhang, H., Yang, D., Wang, H., Wen, S., Liu, J., Luan, Q., Huang, Y., Wang, B., Lin, C., Qian, H."Metastasis‑associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells". Oncology Letters 7.2 (2014): 399-404.
Chicago
Zhang, H., Yang, D., Wang, H., Wen, S., Liu, J., Luan, Q., Huang, Y., Wang, B., Lin, C., Qian, H."Metastasis‑associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells". Oncology Letters 7, no. 2 (2014): 399-404. https://doi.org/10.3892/ol.2013.1729
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