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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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2014-February Volume 7 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Increased miR‑449a expression in colorectal carcinoma tissues is inversely correlated with serum carcinoembryonic antigen

  • Authors:
    • Shaohua Chen
    • Yuqiao Dai
    • Xuemei Zhang
    • Daozhong Jin
    • Xiaorong Li
    • Yi Zhang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China, Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri‑Kansas, Kansas City, KS 64108, USA, Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China, Department of Basic Medical Sciences, School of Medicine, University of Missouri‑Kansas, Kansas City, KS 64108, USA
  • Pages: 568-572
    |
    Published online on: December 6, 2013
       https://doi.org/10.3892/ol.2013.1737
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Abstract

Previously, microRNA‑449a (miR‑449a) has been shown to be involved in various types of cancer. However, its role in colorectal carcinoma remains unknown. The present study found that miR‑449a expression was significantly increased in cultured colorectal carcinoma cells and cancer tissues obtained from 24 patients diagnosed with colorectal carcinoma, compared with the normal colorectal cells and the adjacent non‑tumor tissues. The miR‑449a expression in carcinoma tissues revealed an inverse correlation with the levels of serum carcinoembryonic antigen (CEA; R2=0.88). The increased expression of miR‑449a appeared in the patients who exhibited normal serum levels of CEA (<5 ng/ml), but not in those with elevated CEA levels (>5 ng/ml). miR‑449a expression increased at an early TNM stage (stage II) and did not change significantly at stages III and IV. These results suggested that miR‑449a is involved in the development of colorectal carcinoma and may be a potential prognosis indicator.
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1 

Corté H, Manceau G, Blons H and Laurent-Puig P: MicroRNA and colorectal cancer. Dig Liver Dis. 44:195–200. 2012.

2 

Boyle P and Levin B: Colorectal cancer. World Cancer Report 2008. IARC Press; Lyon: pp. 374–378. 2008

3 

Farazi TA, Hoell JI, Morozov P and Tuschl T: MicroRNAs in Human Cancer. Adv Exp Med Biol. 774:1–20. 2013. View Article : Google Scholar

4 

Zhu W, Liu X, He J, Chen D, Hunag Y and Zhang YK: Overexpression of members of the microRNA-183 family is a risk factor for lung cancer: a case control study. BMC Cancer. 11:3932011. View Article : Google Scholar : PubMed/NCBI

5 

Noonan EJ, Place RF, Pookot D, Basak S, Whitson JM, Hirata H, Giardina C and Dahiya R: miR-449a targets HDAC-1 and induces growth arrest in prostate cancer. Oncogene. 28:1714–1724. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Noonan EJ, Place RF, Basak S, Pookot D and Li LC: miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells. Oncotarget. 1:349–358. 2010.PubMed/NCBI

7 

Jeon HS, Lee SY, Lee EJ, Yun SC, Cha EJ, Choi E, Na MJ, Park JY, Kang J and Son JW: Combining microRNA-449a/b with a HDAC inhibitor has a synergistic effect on growth arrest in lung cancer. Lung Cancer. 76:171–176. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Buurman R, Gürlevik E, Schäffer V, Eilers M, Sandbothe M, Kreipe H, Wilkens L, Schlegelberger B, Kühnel F and Skawran B: Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells. Gastroenterology. 143:811–820. 2012. View Article : Google Scholar

9 

Bou Kheir T, Futoma-Kazmierczak E, Jacobsen A, Krogh A, Bardram L, Hother C, Grønbæk K, Federspiel B, Lund AH and Friis-Hansen L: miR-449 inhibits cell proliferation and is down-regulated in gastric cancer. Mol Cancer. 18;10:292011.PubMed/NCBI

10 

Zhang Q, He XJ, Ma LP, Li N, Yang J, Cheng YX and Cui H: Expression and significance of microRNAs in the p53 pathway in ovarian cancer cells and serous ovarian cancer tissues. Zhonghua Zhong Liu Za Zhi. 33:885–890. 2011.(In Chinese).

11 

Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M and Yu Q: miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev. 23:2388–2393. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Chen H, Lin YW, Mao YQ, Wu J, Liu YF, Zheng XY and Xie LP: MicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins. Cancer Lett. 320:40–47. 2012. View Article : Google Scholar

13 

Lizé M, Pilarski S and Dobbelstein M: E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis. Cell Death Differ. 17:452–458. 2010.PubMed/NCBI

14 

Guo C, Sah JF, Beard L, Willson JK, Markowitz SD and Guda K: The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosomes Cancer. 47:939–946. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Lardizábal MN, Nocito AL, Daniele SM, Ornella LA, Palatnik JF and Veggi LM: Reference genes for real-time PCR quantification of microRNAs and messenger RNAs in rat models of hepatotoxicity. PLoS One. 7:e363232012.PubMed/NCBI

16 

Liu M, Tang Q, Qiu M, Lang N, Li M, Zheng Y and Bi F: miR-21 targets the tumor suppressor RhoB and regulates proliferation, invasion and apoptosis in colorectal cancer cells. FEBS Lett. 585:2998–3005. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Watahiki A and Wang Y, Morris J, Dennis K, O’Dwyer HM, Gleave M, Gout PW and Wang Y: MicroRNAs associated with metastatic prostate cancer. PLoS One. 6:e249502011. View Article : Google Scholar : PubMed/NCBI

18 

Mihelich BL, Khramtsova EA, Arva N, Vaishnav A, Johnson DN, Giangreco AA, Martens-Uzunova E, Bagasra O, Kajdacsy-Balla A and Nonn L: miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells. J Biol Chem. 286:44503–44511. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Yu S, Lu Z, Liu C, Meng Y, Ma Y, Zhao W, Liu J, Yu J and Chen J: miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer. Cancer Res. 70:6015–6025. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Boras Z, Kondza G, Sisljagić V, Busić Z, Gmajnić R and Istvanić T: Prognostic factors of local recurrence and survival after curative rectal cancer surgery: a single institution experience. Coll Antropol. 36:1355–1361. 2012.

21 

Meimarakis G, Angele M, Conrad C, Schauer R, Weidenhagen R, Crispin A, Giessen C, Preissler G, Wiedemann M, Jauch KW, et al: Combined resection of colorectal hepatic-pulmonary metastases shows improved outcome over chemotherapy alone. Langenbecks Arch Surg. 398:265–276. 2013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Chen S, Dai Y, Zhang X, Jin D, Li X and Zhang Y: Increased miR‑449a expression in colorectal carcinoma tissues is inversely correlated with serum carcinoembryonic antigen. Oncol Lett 7: 568-572, 2014.
APA
Chen, S., Dai, Y., Zhang, X., Jin, D., Li, X., & Zhang, Y. (2014). Increased miR‑449a expression in colorectal carcinoma tissues is inversely correlated with serum carcinoembryonic antigen. Oncology Letters, 7, 568-572. https://doi.org/10.3892/ol.2013.1737
MLA
Chen, S., Dai, Y., Zhang, X., Jin, D., Li, X., Zhang, Y."Increased miR‑449a expression in colorectal carcinoma tissues is inversely correlated with serum carcinoembryonic antigen". Oncology Letters 7.2 (2014): 568-572.
Chicago
Chen, S., Dai, Y., Zhang, X., Jin, D., Li, X., Zhang, Y."Increased miR‑449a expression in colorectal carcinoma tissues is inversely correlated with serum carcinoembryonic antigen". Oncology Letters 7, no. 2 (2014): 568-572. https://doi.org/10.3892/ol.2013.1737
Copy and paste a formatted citation
x
Spandidos Publications style
Chen S, Dai Y, Zhang X, Jin D, Li X and Zhang Y: Increased miR‑449a expression in colorectal carcinoma tissues is inversely correlated with serum carcinoembryonic antigen. Oncol Lett 7: 568-572, 2014.
APA
Chen, S., Dai, Y., Zhang, X., Jin, D., Li, X., & Zhang, Y. (2014). Increased miR‑449a expression in colorectal carcinoma tissues is inversely correlated with serum carcinoembryonic antigen. Oncology Letters, 7, 568-572. https://doi.org/10.3892/ol.2013.1737
MLA
Chen, S., Dai, Y., Zhang, X., Jin, D., Li, X., Zhang, Y."Increased miR‑449a expression in colorectal carcinoma tissues is inversely correlated with serum carcinoembryonic antigen". Oncology Letters 7.2 (2014): 568-572.
Chicago
Chen, S., Dai, Y., Zhang, X., Jin, D., Li, X., Zhang, Y."Increased miR‑449a expression in colorectal carcinoma tissues is inversely correlated with serum carcinoembryonic antigen". Oncology Letters 7, no. 2 (2014): 568-572. https://doi.org/10.3892/ol.2013.1737
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