Disseminated Fusarium infection in a patient with acute lymphoblastic leukemia: A case report and review of the literature

Liu,Yi‑Sheng; Wang,Ning‑Chi; Ye,Ren‑Hua; Kao,Wei‑Yao

doi:10.3892/ol.2013.1738

2014-February Volume 7 Issue 2

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2014-February Volume 7 Issue 2

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Case Report

Disseminated Fusarium infection in a patient with acute lymphoblastic leukemia: A case report and review of the literature

Authors:
- Yi‑Sheng Liu
- Ning‑Chi Wang
- Ren‑Hua Ye
- Wei‑Yao Kao
View Affiliations / Copyright

Affiliations: Division of Hematology and Oncology, Department of Medicine, Tri‑Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan, R.O.C., Division of Infectious Disease, Department of Medicine, Tri‑Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan, R.O.C.
Pages: 334-336
|
Published online on: December 6, 2013

https://doi.org/10.3892/ol.2013.1738
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Abstract

Fusarium is a common soil mold. In severely immunocompromised patients, this fungus may cause disseminated disease and is often confused with Aspergillus, as the two pathogens have similar histopathological appearances. Disseminated Fusarium infection may cause significant morbidity and mortality in immunocompromised patients. The current case report presents a 20‑year‑old male with acute lymphoblastic leukemia who developed disseminated Fusarium infection during induction chemotherapy. Early diagnosis and treatment is extremely important since the mortality rate is extremely high in such patients. The clinician must consider that the clinical presentation of Fusarium infection resembles that of Aspergillus. There is no optimal treatment for patients with Fusarium infection; however, combination antifungal therapy may have benefit without significant toxicity.

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1	Pagano L, Caira M, Candoni A, et al: The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study. Haematologica. 91:1068–1075. 2006.PubMed/NCBI
2	Böhme A, Ruhnke M, Buchheidt D, et al: Treatment of invasive fungal infections in cancer patients - recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann Hematol. 88:97–110. 2009.
3	Girmenia C, Pagano L, Corvatta L, et al: The epidemiology of fusariosis in patients with haematological diseases. Gimema Infection Programme. Br J Haematol. 111:272–276. 2000. View Article : Google Scholar : PubMed/NCBI
4	Boutati EI and Anaissie EJ: Fusarium, a significant emerging pathogen in patients with hematologic malignancy: ten years’ experience at a cancer center and implications for management. Blood. 90:999–1008. 1997.PubMed/NCBI
5	Nucci M and Anaissie E: Fusarium infections in immunocompromised patients. Clin Microbiol Rev. 20:695–704. 2007. View Article : Google Scholar
6	Liang DC, Yang CP, Lin DT, et al: Long-term results of Taiwan Pediatric Oncology Group studies 1997 and 2002 for childhood acute lymphoblastic leukemia. Leukemia. 24:397–405. 2010. View Article : Google Scholar : PubMed/NCBI
7	Fleischhack G, Hasan C, Graf N, Mann G and Bode U: IDA-FLAG (idarubicin, fludarabine, cytarabine, G-CSF), an effective remission-induction therapy for poor-prognosis AML of childhood prior to allogeneic or autologous bone marrow transplantation: experiences of a phase II trial. Br J Haematol. 102:647–655. 1998. View Article : Google Scholar
8	Nucci M, Anaissie EJ, Queiroz-Telles F, et al: Outcome predictors of 84 patients with hematologic malignancies and Fusarium infection. Cancer. 98:315–319. 2003. View Article : Google Scholar : PubMed/NCBI
9	Dignani MC and Anaissie EJ: Human fusariosis. Clin Microbiol Infect. 10(Suppl 1): 67–75. 2004. View Article : Google Scholar
10	Chaoui D, Legrand O, Roche N, et al: Incidence and prognostic value of respiratory events in acute leukemia. Leukemia. 18:670–675. 2004. View Article : Google Scholar : PubMed/NCBI
11	Grigis A, Farina C, Symoens F, Nolard N and Goglio A: Nosocomial pseudo-outbreak of Fusarium verticillioides associated with sterile plastic containers. Infect Control Hosp Epidemiol. 21:50–52. 2000.
12	Rüping MJ, Vehreschild JJ and Cornely OA: Antifungal treatment strategies in high risk patients. Mycoses. 51(Suppl 2): 46–51. 2008.
13	Tortorano AM, Esposto MC, Prigitano A, Grancini A, Ossi C, Cavanna C and Cascio GL: Cross-reactivity of Fusarium spp. in the Aspergillus Galactomannan enzyme-linked immunosorbent assay. J Clin Microbiol. 50:1051–1053. 2012.
14	Cetkovsky P, Kouba M, Markova M, et al: Combination of voriconazole and anidulafungin as primary therapy in hematologic patients. Biol Blood Marrow Transplant. 16:S2642010. View Article : Google Scholar
15	Rojas R, Molina JR, Jarque I, et al: Outcome of antifungal combination therapy for invasive mold infections in hematological patients is independent for chosen combination. Mediterr J Hematol Infect Dis. 4:e20120112012. View Article : Google Scholar
16	Liu JY, Chen WT, Ko BS, et al: Combination antifungal therapy for disseminated fusariosis in immunocompromised patients: a case report and literature review. Med Mycol. 49:872–878. 2011.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Disseminated Fusarium infection in a patient with acute lymphoblastic leukemia: A case report and review of the literature

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