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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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2014-February Volume 7 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Clinical significance of Girdin expression detected by immunohistochemistry in non‑small cell lung cancer

  • Authors:
    • Jing‑Ying Song
    • Ping Jiang
    • Ning Li
    • Feng‑Hua Wang
    • Jun Luo
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The 309th Hospital of Chinese People's Liberation Army, Beijing 100091, P.R. China, The Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing 100730, P.R. China
  • Pages: 337-341
    |
    Published online on: December 9, 2013
       https://doi.org/10.3892/ol.2013.1745
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Abstract

Girdin protein has been implicated in cell migration and proliferation control. Previous evidence has confirmed that Girdin is a pivotal protein during cancer progression. To date, no evidence has been identified for the clinical significance of Girdin expression in non‑small cell lung cancer (NSCLC). The current study aimed to investigate the expression and clinical significance of Girdin protein in NSCLC. In total, 36 tumor samples were obtained from patients undergoing surgery for NSCLC at The 309th Hospital of Chinese People's Liberation Army (Beijing, China). The protein expression of Girdin was determined by immunohistochemistry analysis and the levels of Girdin protein were significantly higher in tumor samples than in distal normal lung tissue. A significant correlation was identified between Girdin overexpression and blood vessel infiltration of the tumor (P=0.013). Furthermore, analysis found that the Girdin‑high phenotype was not associated with higher Ki‑67 score. Girdin protein was frequently overexpressed in NSCLC and expression of Girdin was associated with blood vessel infiltration. The results of the present study suggest that Girdin should be considered as a potential marker for the prognosis of NSCLC; however, future studies are required to confirm theses results.
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Copy and paste a formatted citation
Spandidos Publications style
Song JY, Jiang P, Li N, Wang FH and Luo J: Clinical significance of Girdin expression detected by immunohistochemistry in non‑small cell lung cancer. Oncol Lett 7: 337-341, 2014.
APA
Song, J., Jiang, P., Li, N., Wang, F., & Luo, J. (2014). Clinical significance of Girdin expression detected by immunohistochemistry in non‑small cell lung cancer. Oncology Letters, 7, 337-341. https://doi.org/10.3892/ol.2013.1745
MLA
Song, J., Jiang, P., Li, N., Wang, F., Luo, J."Clinical significance of Girdin expression detected by immunohistochemistry in non‑small cell lung cancer". Oncology Letters 7.2 (2014): 337-341.
Chicago
Song, J., Jiang, P., Li, N., Wang, F., Luo, J."Clinical significance of Girdin expression detected by immunohistochemistry in non‑small cell lung cancer". Oncology Letters 7, no. 2 (2014): 337-341. https://doi.org/10.3892/ol.2013.1745
Copy and paste a formatted citation
x
Spandidos Publications style
Song JY, Jiang P, Li N, Wang FH and Luo J: Clinical significance of Girdin expression detected by immunohistochemistry in non‑small cell lung cancer. Oncol Lett 7: 337-341, 2014.
APA
Song, J., Jiang, P., Li, N., Wang, F., & Luo, J. (2014). Clinical significance of Girdin expression detected by immunohistochemistry in non‑small cell lung cancer. Oncology Letters, 7, 337-341. https://doi.org/10.3892/ol.2013.1745
MLA
Song, J., Jiang, P., Li, N., Wang, F., Luo, J."Clinical significance of Girdin expression detected by immunohistochemistry in non‑small cell lung cancer". Oncology Letters 7.2 (2014): 337-341.
Chicago
Song, J., Jiang, P., Li, N., Wang, F., Luo, J."Clinical significance of Girdin expression detected by immunohistochemistry in non‑small cell lung cancer". Oncology Letters 7, no. 2 (2014): 337-341. https://doi.org/10.3892/ol.2013.1745
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