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Article

Effect of perioperative glucocorticoid administration on postoperative complications following esophagectomy: A meta‑analysis

  • Authors:
    • Qiang Gao
    • Mok Hsiao-Pei
    • Wen‑Ping Wang
    • Xiao-Fei Zuo
    • Long‑Qi Chen
  • View Affiliations / Copyright

    Affiliations: West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 349-356
    |
    Published online on: December 10, 2013
       https://doi.org/10.3892/ol.2013.1748
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Abstract

Perioperative corticosteroid administration is a controversial therapy for improving the short‑term prognosis following surgery. The objective of the current meta‑analysis was to evaluate the effects of the perioperative use of corticosteroids during esophagectomy for esophageal carcinoma. A comprehensive study was performed using references selected from the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, MEDLINE (Ovid databases), EMBASE and three Chinese databases (Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure and VIP Database for Chinese Technical Periodicals). Eligible studies were restricted to randomized clinical trials that reported data from patients undergoing esophagectomy. In addition, treated groups of patients received perioperative corticosteroid administration and control groups received a placebo infusion, such as saline water. The studies evaluated the incidence of postoperative complications and the variation of inflammatory mediators. All extracted data underwent meta‑analysis using Review Manager 5.1 software. Only six studies were eligible for selection. The following parameters were found to be reduced following the use of methylprednisolone: Interleukin (IL)‑6 immediately following surgery and on postoperative days (PODs) 1 and 3; IL‑8 immediately following surgery; and PaO2/FiO2 on POD 3. Moreover, organ failure, cardiovascular complications and pulmonary morbidity were all reduced in patients with corticosteroid usage. Certain factors showed no significant differences between the treated and control groups, including IL‑8 on POD 1, IL‑6 prior to surgery and on POD 5, PaO2/FiO2 following surgery, mortality, anastomotic leakage, severe infection and renal and hepatic failure. Prophylactic administration of methylprednisolone during the perioperative period may reduce the incidence of specific types of postoperative complications and inhibit the postoperative inflammatory reaction. Additional randomized controlled trials must be performed.
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Copy and paste a formatted citation
Spandidos Publications style
Gao Q, Hsiao-Pei M, Wang WP, Zuo X and Chen LQ: Effect of perioperative glucocorticoid administration on postoperative complications following esophagectomy: A meta‑analysis. Oncol Lett 7: 349-356, 2014.
APA
Gao, Q., Hsiao-Pei, M., Wang, W., Zuo, X., & Chen, L. (2014). Effect of perioperative glucocorticoid administration on postoperative complications following esophagectomy: A meta‑analysis. Oncology Letters, 7, 349-356. https://doi.org/10.3892/ol.2013.1748
MLA
Gao, Q., Hsiao-Pei, M., Wang, W., Zuo, X., Chen, L."Effect of perioperative glucocorticoid administration on postoperative complications following esophagectomy: A meta‑analysis". Oncology Letters 7.2 (2014): 349-356.
Chicago
Gao, Q., Hsiao-Pei, M., Wang, W., Zuo, X., Chen, L."Effect of perioperative glucocorticoid administration on postoperative complications following esophagectomy: A meta‑analysis". Oncology Letters 7, no. 2 (2014): 349-356. https://doi.org/10.3892/ol.2013.1748
Copy and paste a formatted citation
x
Spandidos Publications style
Gao Q, Hsiao-Pei M, Wang WP, Zuo X and Chen LQ: Effect of perioperative glucocorticoid administration on postoperative complications following esophagectomy: A meta‑analysis. Oncol Lett 7: 349-356, 2014.
APA
Gao, Q., Hsiao-Pei, M., Wang, W., Zuo, X., & Chen, L. (2014). Effect of perioperative glucocorticoid administration on postoperative complications following esophagectomy: A meta‑analysis. Oncology Letters, 7, 349-356. https://doi.org/10.3892/ol.2013.1748
MLA
Gao, Q., Hsiao-Pei, M., Wang, W., Zuo, X., Chen, L."Effect of perioperative glucocorticoid administration on postoperative complications following esophagectomy: A meta‑analysis". Oncology Letters 7.2 (2014): 349-356.
Chicago
Gao, Q., Hsiao-Pei, M., Wang, W., Zuo, X., Chen, L."Effect of perioperative glucocorticoid administration on postoperative complications following esophagectomy: A meta‑analysis". Oncology Letters 7, no. 2 (2014): 349-356. https://doi.org/10.3892/ol.2013.1748
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