Salivary gland tumors: A 20‑year review of clinical diagnostic accuracy at a single center

Lee,Wei‑Han; Tseng,Te‑Ming; Hsu,Hsin‑Te; Lee,Fei‑Peng; Hung,Shih‑Han; Chen,Po‑Yueh

doi:10.3892/ol.2013.1750

Salivary gland tumors: A 20‑year review of clinical diagnostic accuracy at a single center

Authors:
- Wei‑Han Lee
- Te‑Ming Tseng
- Hsin‑Te Hsu
- Fei‑Peng Lee
- Shih‑Han Hung
- Po‑Yueh Chen
View Affiliations

Affiliations: Department of Otolaryngology, Head and Neck Surgery, Taipei Medical University‑Shuang Ho Hospital, Taipei 110, Taiwan, R.O.C., Department of Otolaryngology, Taipei Medical University Hospital, Taipei 110, Taiwan, R.O.C.
Published online on: December 10, 2013 https://doi.org/10.3892/ol.2013.1750
Pages: 583-587

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Obtaining reliable pre‑operative diagnosis is crucial in planning treatment for patients with salivary gland tumors. The purpose of this study was to evaluate the accuracy of pre‑operative clinical diagnosis of salivary gland tumors managed at a single tertiary university hospital over a period of 20 years. A retrospective analysis of the period between 1992 and 2011 was carried out to review the cases of patients with salivary gland tumors. A total of 101 patients were enrolled and general data were described. Clinical diagnosis was compared with the final pathological diagnosis to reveal the clinical diagnostic accuracy. Of the parotid and submandibular gland tumors, 86 and 67% were benign, respectively. The clinical diagnostic accuracies for diagnosis of parotid tumors as benign or malignant were 100 and 57%, respectively. The clinical diagnostic accuracies for diagnosis of submandibular tumors as benign or malignant were 67%. Therefore, the overall clinical judgment of benign and malignant tumors in the submandibular gland is unreliable. The accuracy for a parotid tumor to be clinically interpreted as benign was 100%. While it is difficult to draw any conclusion for non‑parotid gland tumors, surgical intervention should be recommended in patients with parotid tumors clinically suspected to be malignant, and all submandibular, sublingual and minor salivary gland tumors.

View Figures

View References

1	Cancer Registry Annual Report. Bureau of Health Promotion, Department of Health; Taiwan: 2009, http://www.hpa.gov.tw/Bhpnet/Web/Stat/Statistics.aspx. Accessed August 13, 2012
2	Katoh T, Ishige T, Kasai H, et al: Malignant parotid gland tumors and facial nerve paralysis. Arch Otorhinolaryngol. 240:139–144. 1984.PubMed/NCBI
3	Eneroth CM: Facial nerve paralysis. A criterion of malignancy in parotid tumors. Arch Otolaryngol. 95:300–304. 1972. View Article : Google Scholar : PubMed/NCBI
4	Kechagias N, Ntomouchtsis A, Valeri R, et al: Fine-needle aspiration cytology of salivary gland tumours: a 10-year retrospective analysis. Oral Maxillofac Surg. 16:35–40. 2012.PubMed/NCBI
5	Taylor MJ, Serpell JW and Thomson P: Preoperative fine needle cytology and imaging facilitates the management of submandibular salivary gland lesions. ANZ J Surg. 81:70–74. 2011. View Article : Google Scholar
6	Sharma G, Jung AS, Maceri DR, Rice DH, Martin SE and Grant EG: US-guided fine-needle aspiration of major salivary gland masses and adjacent lymph nodes: accuracy and impact on clinical decision making. Radiology. 259:471–478. 2011. View Article : Google Scholar
7	Viguer JM, Vicandi B, Jiménez-Heffernan JA, López-Ferrer P, Gonzalez-Peramato P and Castillo C: Role of fine needle aspiration cytology in the diagnosis and management of Warthin’s tumour of the salivary glands. Cytopathology. 21:164–169. 2010.
8	Christensen RK, Bjørndal K, Godballe C and Krogdahl A: Value of fine-needle aspiration biopsy of salivary gland lesions. Head Neck. 32:104–108. 2010.PubMed/NCBI
9	Chakrabarti S, Bera M, Bhattacharya PK, et al: Study of salivary gland lesions with fine needle aspiration cytology and histopothology along with immunohistochemistry. J Indian Med Assoc. 108:833–836. 2010.
10	Gonçalves AJ, Menezes MB, Kavabata NK, Bertelli AA, Souza RA and Joelsons D: Fine needle aspiration in salivary gland tumors: specificity and sensitivity. Rev Assoc Med Bras. 53:267–271. 2007.(In Portuguese).
11	Mihashi H, Kawahara A, Kage M, et al: Comparison of preoperative fine-needle aspiration cytology diagnosis and histopathological diagnosis of salivary gland tumors. Kurume Med J. 53:23–27. 2006. View Article : Google Scholar : PubMed/NCBI
12	Cohen EG, Patel SG, Lin O, et al: Fine-needle aspiration biopsy of salivary gland lesions in a selected patient population. Arch Otolaryngol Head Neck Surg. 130:773–778. 2004. View Article : Google Scholar : PubMed/NCBI
13	Eng CY, Evans AS, Quraishi MS and Harkness PA: A comparison of the incidence of facial palsy following parotidectomy performed by ENT and non-ENT surgeons. J Laryngol Otol. 121:40–43. 2007.
14	Guntinas-Lichius O, Gabriel B and Klussmann JP: Risk of facial palsy and severe Frey’s syndrome after conservative parotidectomy for benign disease: analysis of 610 operations. Acta Otolaryngol. 126:1104–1109. 2006.
15	Wang YL, Li DS, Gan HL, et al: Predictive index for lymph node management of major salivary gland cancer. Laryngoscope. 122:1497–1506. 2012. View Article : Google Scholar : PubMed/NCBI
16	Ishinaga H, Kato A and Yamada H: Neck dissection for salivary gland carcinoma. Nihon Jibiinkoka Gakkai Kaiho. 101:895–899. 1998.(In Japanese).
17	Medina JE: Neck dissection in the treatment of cancer of major salivary glands. Otolaryngol Clin North Am. 31:815–822. 1998. View Article : Google Scholar : PubMed/NCBI
18	Korkmaz H, Yoo GH, Du W, et al: Predictors of nodal metastasis in salivary gland cancer. J Surg Oncol. 80:186–189. 2002. View Article : Google Scholar : PubMed/NCBI
19	Ivanová S, Slobodníková J, Janská E and Jozefáková J: Fine needle aspiration biopsy in a diagnostic workup algorithm of salivary gland tumors. Neoplasma. 50:144–147. 2003.PubMed/NCBI
20	Oka K, Chikamatsu K, Eura M, Katsura F, Yumoto E and Tokunaga H: Clinical significance of fine-needle aspiration biopsy in major salivary gland tumors. Nihon Jibiinkoka Gakkai Kaiho. 105:1109–1115. 2002.(In Japanese).
21	Al-Khafaji BM and Afify AM: Salivary gland fine needle aspiration using the ThinPrep technique: diagnostic accuracy, cytologic artifacts and pitfalls. Acta Cytol. 45:567–574. 2001. View Article : Google Scholar
22	Stewart CJ, MacKenzie K, McGarry GW and Mowat A: Fine-needle aspiration cytology of salivary gland: a review of 341 cases. Diagn Cytopathol. 22:139–146. 2000. View Article : Google Scholar : PubMed/NCBI
23	Jan IS, Chung PF, Weng MH, et al: Analysis of fine-needle aspiration cytology of the salivary gland. J Formos Med Assoc. 107:364–370. 2008. View Article : Google Scholar : PubMed/NCBI
24	Murai N, Taniguchi Z, Takahashi Y, Yasuhara Y, Kuboshima F and Tateya I: A study of salivary gland aspiration cytology reporting: guideline validity. Nihon Jibiinkoka Gakkai Kaiho. 114:615–619. 2011.(In Japanese).
25	Folia M, Kany M, Fillola G, Serrano E and Pessey JJ: Value of of fine-needle aspiration cytology and MRI in parotid gland masses. Rev Laryngol Otol Rhinol (Bord). 123:153–157. 2002.(In French).
26	Jafari A, Royer B, Lefevre M, Corlieu P, Périé S and St Guily JL: Value of the cytological diagnosis in the treatment of parotid tumors. Otolaryngol Head Neck Surg. 140:381–385. 2009. View Article : Google Scholar : PubMed/NCBI
27	Schmitt G, Lehmann G, Strötges MW, et al: The diagnostic value of sialography and scintigraphy in salivary gland diseases. Br J Radiol. 49:326–329. 1976. View Article : Google Scholar : PubMed/NCBI
28	Schall GL, Smith RR and Barsocchini LM: Radionuclide salivary imaging usefulness in a private otolaryngology practice. Arch Otolaryngol. 107:40–44. 1981. View Article : Google Scholar : PubMed/NCBI
29	Isacsson G, Isberg A, Haverling M and Lundquist PG: Salivary calculi and chronic sialoadenitis of the submandibular gland: a radiographic and histologic study. Oral Surg Oral Med Oral Pathol. 58:622–627. 1984. View Article : Google Scholar : PubMed/NCBI
30	Chisin R, Markitziu A, Hoffer S, Shani J and Atlan H: The clinical value of quantitative dynamic scintigraphy in salivary gland disorders. Int J Rad Appl Instrum B. 15:313–317. 1988. View Article : Google Scholar
31	Arbab AS, Koizumi K, Toyama K, et al: Various imaging modalities for the detection of salivary gland lesions: the advantages of 201Tl SPET. Nucl Med Commun. 21:277–284. 2000. View Article : Google Scholar : PubMed/NCBI
32	Salaffi F, Carotti M, Argalia G, Salera D, Giuseppetti GM and Grassi W: Usefulness of ultrasonography and color Doppler sonography in the diagnosis of major salivary gland diseases. Reumatismo. 58:138–156. 2006.(In Italian).
33	Nakahara T, Suzuki T, Hashimoto J, et al: Role of salivary gland scintigraphy with Tc-99m pertechnetate in determining treatment of solitary parotid gland tumors: a retrospective study. Clin Nucl Med. 32:363–366. 2007. View Article : Google Scholar
34	Klein K, Turk R, Gritzmann N and Traxler M: The value of sonography in salivary gland tumors. HNO. 37:71–75. 1989.(In German).
35	Prades JM, Oletski A, Faye MB, et al: Parotid gland masses: diagnostic value of MR imaging with histopathologic correlations. Morphologie. 91:44–51. 2007.(In French).
36	Khan N, Oriuchi N, Ninomiya H, Higuchi T, Kamada H and Endo K: Positron emission tomographic imaging with ¹¹C-choline in differential diagnosis of head and neck tumors: comparison with ¹⁸F-FDG PET. Ann Nucl Med. 18:409–417. 2004.
37	Jeong HS, Chung MK, Son YI, et al: Role of ¹⁸F-FDG PET/CT in management of high-grade salivary gland malignancies. J Nucl Med. 48:1237–1244. 2007.