Small cell neuroendocrine carcinoma of the ureter: A case report and literature review

Ping,Jiang Hai; Chen,Zhang Xiao; Jiong,Qian; Han,You Qi; Nong,Xu

doi:10.3892/ol.2013.1757

Small cell neuroendocrine carcinoma of the ureter: A case report and literature review

Authors:
- Jiang Hai Ping
- Zhang Xiao Chen
- Qian Jiong
- You Qi Han
- Xu Nong
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Affiliations: Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Department of Pathology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
Published online on: December 12, 2013 https://doi.org/10.3892/ol.2013.1757
Pages: 728-730

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Abstract

Small cell neuroendocrine carcinoma arising in the ureter is extremely rare; only a few cases have been previously reported in the literature. The current study reports the case of a 65‑year‑old female who presented with right‑sided back pain. A mass was identified in the right ureter, and a nephroureterectomy was performed. The microscopic examination revealed that the mass was composed of a monotonous population of small cells and that the cells of the carcinoma were positive for cluster of differentiation 56, chromogranin A and synaptophysin. The tumor was diagnosed as a ureteral neuroendocrine small cell carcinoma. The patient returned 4 months later with recurrences in the retroperitoneum. Chemotherapy was administered and following 80 mg/m2 intravenous irinotecan on days 1 and 8 and 25 mg/m2 cisplatin on days 1‑3, every 21 days for 4 cycles, the tumor was considerably smaller. During the regular follow‑up examinations, the tumor remained stable.

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