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Article

Introduction and utility of liquid‑based cytology on aspiration biopsy of peripheral nodular lesions of the lung

  • Authors:
    • Johji Imura
    • Kaori Abe
    • Yoshiaki Uchida
    • Masaharu Shibata
    • Kazue Tsunematsu
    • Motohiro Sathoh
    • Shigeharu Miwa
    • Takahiko Nakajima
    • Kazuhiro Nomoto
    • Shinichi Hayashi
    • Koichi Tsuneyama
  • View Affiliations / Copyright

    Affiliations: Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930‑0194, Japan, Department of Pathology, Ibaraki Prefectural Central Hospital, Kasama 309-1793, Japan, Department of Radiology, Ibaraki Prefectural Central Hospital, Kasama 309-1793, Japan
  • Pages: 669-673
    |
    Published online on: December 17, 2013
       https://doi.org/10.3892/ol.2013.1763
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Abstract

In the present study, aspiration biopsy cytology (ABC) was used for the diagnosis of peripheral nodular lesions in the lung (PNLL), and liquid‑based cytology (LBC) was carried out on the material collected to evaluate it in comparison with the conventional method (CM). The subjects comprised 130 cases that underwent computed tomography (CT)‑guided ABC for PNLL. A total of 73 cases received a tumor resection, with a diagnosis based on the pathology, while 57 cases were followed up, as the tumor showed no change on the radiological examinations. Biopsy samples from these patients and lavage fluid from the aspiration needles were used for analysis. Cellular material was obtained by centrifugation of the lavage fluid, and samples were prepared by two methods, direct smearing and LBC according to the ThinPrep method. The samples were categorized into three diagnoses: i) Benign, ii) suspicion of malignancy and iii) malignant. Appropriate samples were collected in 72% of cases by LBC, but only in 36% of cases by the CM. There was no marked difference in cellular images between the two methods, with the exception of a few specific cases. LBC on its own provided sensitivity at 68%, specificity at 61% and accuracy at 65%, while a combination of LBC and biopsy markedly improved these figures to 94, 81 and 84%, respectively. The introduction of LBC is considered useful for the cytopathological diagnosis of PNLL by CT‑guided ABC. LBC enables the examination of appropriate samples rich in cellular components and supports a biopsy‑based diagnosis. A combination of these two methods provides even higher diagnostic accuracy, and LBC is considered an excellent method to evaluate these pathological samples.
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Copy and paste a formatted citation
Spandidos Publications style
Imura J, Abe K, Uchida Y, Shibata M, Tsunematsu K, Sathoh M, Miwa S, Nakajima T, Nomoto K, Hayashi S, Hayashi S, et al: Introduction and utility of liquid‑based cytology on aspiration biopsy of peripheral nodular lesions of the lung. Oncol Lett 7: 669-673, 2014.
APA
Imura, J., Abe, K., Uchida, Y., Shibata, M., Tsunematsu, K., Sathoh, M. ... Tsuneyama, K. (2014). Introduction and utility of liquid‑based cytology on aspiration biopsy of peripheral nodular lesions of the lung. Oncology Letters, 7, 669-673. https://doi.org/10.3892/ol.2013.1763
MLA
Imura, J., Abe, K., Uchida, Y., Shibata, M., Tsunematsu, K., Sathoh, M., Miwa, S., Nakajima, T., Nomoto, K., Hayashi, S., Tsuneyama, K."Introduction and utility of liquid‑based cytology on aspiration biopsy of peripheral nodular lesions of the lung". Oncology Letters 7.3 (2014): 669-673.
Chicago
Imura, J., Abe, K., Uchida, Y., Shibata, M., Tsunematsu, K., Sathoh, M., Miwa, S., Nakajima, T., Nomoto, K., Hayashi, S., Tsuneyama, K."Introduction and utility of liquid‑based cytology on aspiration biopsy of peripheral nodular lesions of the lung". Oncology Letters 7, no. 3 (2014): 669-673. https://doi.org/10.3892/ol.2013.1763
Copy and paste a formatted citation
x
Spandidos Publications style
Imura J, Abe K, Uchida Y, Shibata M, Tsunematsu K, Sathoh M, Miwa S, Nakajima T, Nomoto K, Hayashi S, Hayashi S, et al: Introduction and utility of liquid‑based cytology on aspiration biopsy of peripheral nodular lesions of the lung. Oncol Lett 7: 669-673, 2014.
APA
Imura, J., Abe, K., Uchida, Y., Shibata, M., Tsunematsu, K., Sathoh, M. ... Tsuneyama, K. (2014). Introduction and utility of liquid‑based cytology on aspiration biopsy of peripheral nodular lesions of the lung. Oncology Letters, 7, 669-673. https://doi.org/10.3892/ol.2013.1763
MLA
Imura, J., Abe, K., Uchida, Y., Shibata, M., Tsunematsu, K., Sathoh, M., Miwa, S., Nakajima, T., Nomoto, K., Hayashi, S., Tsuneyama, K."Introduction and utility of liquid‑based cytology on aspiration biopsy of peripheral nodular lesions of the lung". Oncology Letters 7.3 (2014): 669-673.
Chicago
Imura, J., Abe, K., Uchida, Y., Shibata, M., Tsunematsu, K., Sathoh, M., Miwa, S., Nakajima, T., Nomoto, K., Hayashi, S., Tsuneyama, K."Introduction and utility of liquid‑based cytology on aspiration biopsy of peripheral nodular lesions of the lung". Oncology Letters 7, no. 3 (2014): 669-673. https://doi.org/10.3892/ol.2013.1763
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