Diagnosis of Felty's syndrome, distinguished from hematological neoplasm: A case report

Xiao,Ruo‑Zhi; Xiong,Mu‑Jun; Long,Zi‑Jie; Fan,Rui‑Fang; Lin,Dong‑Jun

doi:10.3892/ol.2013.1779

2014-March Volume 7 Issue 3

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2014-March Volume 7 Issue 3

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Case Report

Diagnosis of Felty's syndrome, distinguished from hematological neoplasm: A case report

Authors:
- Ruo‑Zhi Xiao
- Mu‑Jun Xiong
- Zi‑Jie Long
- Rui‑Fang Fan
- Dong‑Jun Lin
View Affiliations / Copyright

Affiliations: Department of Hematology, Third Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510630, P.R. China
Pages: 713-716
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Published online on: December 27, 2013

https://doi.org/10.3892/ol.2013.1779
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Abstract

Felty's syndrome (FS) is characterized by the three conditions of rheumatoid arthritis (RA), neutropenia and splenomegaly, and occurs in few cases of longstanding erosive RA. Discriminating between rare occurrences of autoimmune diseases and malignancies is crucial. The present study describes the case of a 17‑year‑old female with a two‑year history of RA, presenting with an irregular fever, hepatosplenomegaly and enlarged lymph nodes. The antinuclear antibody titer was 1:320, while antibody results for anti‑dsDNA, anti‑Sm and rheumatoid factor were negative. The clinical presentation was similar to that of lymphoma. However, the fluorodeoxyglucose‑positron emission tomography and biopsy examinations of the liver and cervical lymph node did not support the diagnosis of lymphoma. According to the laboratory results and clinical symptoms, the differential diagnosis indicated FS, and immunosuppressive agents were administered. Two weeks later, the patient no longer had a fever, and the transaminase levels were normal, associated with shrinkage of the liver and spleen.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Diagnosis of Felty's syndrome, distinguished from hematological neoplasm: A case report

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