De novo acute myeloid leukemia subtype‑M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report

  • Authors:
    • Walid Al Achkar
    • Abdulmunim Aljapawe
    • Thomas Liehr
    • Abdulsamad Wafa
  • View Affiliations

  • Published online on: January 8, 2014     https://doi.org/10.3892/ol.2014.1784
  • Pages: 787-790
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Abstract

The t(3;12)(q26;p13) translocation is a recurrent chromosomal aberration observed in myeloid malignancies. The translocation results in the generation of the ETV6/myelodysplastic syndrome 1 (MDS1)/ectopic viral integration site 1 (EVI1) fusion gene. However, the present case report is the first to present this rearrangement in acute myelogeneous leukemia (AML)‑M4. Notably, this case is the first report of AML‑M4 with an initial trisomy 8 and secondary acquired t(3;12)(q26;p13). Cells harboring the t(3;12) translocation were found to exhibit a higher proliferative capacity than cells with pure trisomy 8, which is consistent with the role of the ETV6/MDS1/EVI1 fusion transcript in the development and progression of malignancy.
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2014-March
Volume 7 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Al Achkar W, Aljapawe A, Liehr T and Wafa A: De novo acute myeloid leukemia subtype‑M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report. Oncol Lett 7: 787-790, 2014
APA
Al Achkar, W., Aljapawe, A., Liehr, T., & Wafa, A. (2014). De novo acute myeloid leukemia subtype‑M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report. Oncology Letters, 7, 787-790. https://doi.org/10.3892/ol.2014.1784
MLA
Al Achkar, W., Aljapawe, A., Liehr, T., Wafa, A."De novo acute myeloid leukemia subtype‑M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report". Oncology Letters 7.3 (2014): 787-790.
Chicago
Al Achkar, W., Aljapawe, A., Liehr, T., Wafa, A."De novo acute myeloid leukemia subtype‑M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report". Oncology Letters 7, no. 3 (2014): 787-790. https://doi.org/10.3892/ol.2014.1784