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2014-March Volume 7 Issue 3

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Case Report

De novo acute myeloid leukemia subtype‑M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report

  • Authors:
    • Walid Al Achkar
    • Abdulmunim Aljapawe
    • Thomas Liehr
    • Abdulsamad Wafa
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Biology and Biotechnology, Division of Human Genetics, Atomic Energy Commission of Syria, Damascus 6091, Syria, Laboratory of Flow‑Cytometry, Department of Molecular Biology and Biotechnology, Division of Mammalians Biology, Atomic Energy Commission of Syria, Damascus 6091, Syria, Jena University Hospital, Institute of Human Genetics, Jena 07740, Germany
  • Pages: 787-790
    |
    Published online on: January 8, 2014
       https://doi.org/10.3892/ol.2014.1784
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Abstract

The t(3;12)(q26;p13) translocation is a recurrent chromosomal aberration observed in myeloid malignancies. The translocation results in the generation of the ETV6/myelodysplastic syndrome 1 (MDS1)/ectopic viral integration site 1 (EVI1) fusion gene. However, the present case report is the first to present this rearrangement in acute myelogeneous leukemia (AML)‑M4. Notably, this case is the first report of AML‑M4 with an initial trisomy 8 and secondary acquired t(3;12)(q26;p13). Cells harboring the t(3;12) translocation were found to exhibit a higher proliferative capacity than cells with pure trisomy 8, which is consistent with the role of the ETV6/MDS1/EVI1 fusion transcript in the development and progression of malignancy.
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Copy and paste a formatted citation
Spandidos Publications style
Al Achkar W, Aljapawe A, Liehr T and Wafa A: De novo acute myeloid leukemia subtype‑M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report. Oncol Lett 7: 787-790, 2014.
APA
Al Achkar, W., Aljapawe, A., Liehr, T., & Wafa, A. (2014). De novo acute myeloid leukemia subtype‑M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report. Oncology Letters, 7, 787-790. https://doi.org/10.3892/ol.2014.1784
MLA
Al Achkar, W., Aljapawe, A., Liehr, T., Wafa, A."De novo acute myeloid leukemia subtype‑M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report". Oncology Letters 7.3 (2014): 787-790.
Chicago
Al Achkar, W., Aljapawe, A., Liehr, T., Wafa, A."De novo acute myeloid leukemia subtype‑M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report". Oncology Letters 7, no. 3 (2014): 787-790. https://doi.org/10.3892/ol.2014.1784
Copy and paste a formatted citation
x
Spandidos Publications style
Al Achkar W, Aljapawe A, Liehr T and Wafa A: De novo acute myeloid leukemia subtype‑M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report. Oncol Lett 7: 787-790, 2014.
APA
Al Achkar, W., Aljapawe, A., Liehr, T., & Wafa, A. (2014). De novo acute myeloid leukemia subtype‑M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report. Oncology Letters, 7, 787-790. https://doi.org/10.3892/ol.2014.1784
MLA
Al Achkar, W., Aljapawe, A., Liehr, T., Wafa, A."De novo acute myeloid leukemia subtype‑M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report". Oncology Letters 7.3 (2014): 787-790.
Chicago
Al Achkar, W., Aljapawe, A., Liehr, T., Wafa, A."De novo acute myeloid leukemia subtype‑M4 with initial trisomy 8 and later acquired t(3;12)(q26;p12) leading to ETV6/MDS1/EVI1 fusion transcript expression: A case report". Oncology Letters 7, no. 3 (2014): 787-790. https://doi.org/10.3892/ol.2014.1784
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