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2014-March Volume 7 Issue 3

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Review

Role of motility‑related protein‑1 in promoting the development of several types of cancer (Review)

  • Authors:
    • Han Xuan
    • Xiaotong Hu
    • Jinwen Huang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China, Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China
  • Pages: 611-615
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    Published online on: January 9, 2014
       https://doi.org/10.3892/ol.2014.1786
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Abstract

Motility‑related protein‑1 (CD9), a type of cell surface glycoprotein comprising a four‑pass transmembrane domain that forms multimeric complexes with other cell surface proteins, belongs to the tetraspanins family. From previous studies, we know that CD9 is considered to function primarily as a progression and metastasis suppressor in a variety of cancers, including breast, non‑small cell lung colon and myeloma. However, an expanding body of literature has shown the contradictory outcome that tetraspanin CD9 is also vital in promoting cancer progression in several types of cancer. This review summarizes the recent studies on CD9 and concludes that it does not always act as a progression and metastasis suppressor. Conversely, in specific cases, CD9 may promote tumor progression through the following three aspects: Facilitating tumor cell transmigration, increasing tumor cell motility and hastening the growth of some cancers. In addition, CD9 appears to be an important marker of cancer stem cells in certain types of tumor.
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1 

Zöller M: Tetraspanins: push and pull in suppressing and promoting metastasis. Nat Rev Cancer. 9:40–55. 2009.PubMed/NCBI

2 

Romanska HM and Berditchevski F: Tetraspanins in human epithelial malignancies. J Pathol. 223:4–14. 2011. View Article : Google Scholar

3 

Hemler ME: Targeting of tetraspanin proteins - potential benefits and strategies. Nat Rev Drug Discov. 7:747–758. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Hemler ME: Tetraspanin proteins mediate cellular penetration, invasion and fusion events and define a novel type of membrane microdomain. Annu Rev Cell Dev Biol. 19:397–422. 2003. View Article : Google Scholar

5 

Boucheix C and Rubinstein E: Tetraspanins. Cell Mol Life Sci. 58:1189–1205. 2001. View Article : Google Scholar

6 

Boucheix C, Soria C, Mirshahi M, et al: Characteristics of platelet aggregation induced by the monoclonal antibody ALB6 (acute lymphoblastic leukemia antigen p 24). Inhibition of aggregation by ALB6Fab. FEBS Lett. 161:289–295. 1983. View Article : Google Scholar

7 

Kersey JH, LeBien TW, Abramson CS, Newman R, Sutherland R and Greaves M: P-24: a human leukemia-associated and lymphohemopoietic progenitor cell surface structure identified with monoclonal antibody. J Exp Med. 153:726–731. 1981. View Article : Google Scholar

8 

Ikeyama S, Koyama M, Yamaoko M, Sasada R and Miyake M: Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA. J Exp Med. 177:1231–1237. 1993. View Article : Google Scholar : PubMed/NCBI

9 

Miyake M, Koyama M, Seno M and Ikeyama S: Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility. J Exp Med. 174:1347–1354. 1991. View Article : Google Scholar : PubMed/NCBI

10 

Oritani K, Aoyama K, Tomiyama Y, Kincade PW and Matsuzawa Y: Stromal cell CD9 and the differentiation of hematopoietic stem/progenitor cells. Leuk Lymphoma. 38:147–152. 2000.PubMed/NCBI

11 

Miyake M, Nakano K, Itoi SI, Koh T and Taki T: Motility-related protein-1 (MRP-1/CD9) reduction as a factor of poor prognosis in breast cancer. Cancer Res. 56:1244–1249. 1996.PubMed/NCBI

12 

Mori M, Mimori K, Shiraishi T, et al: Motility related protein 1 (MRP1/CD9) expression in colon cancer. Clin Cancer Res. 4:1507–1510. 1998.PubMed/NCBI

13 

Higashiyama M, Doi O, Kodama K, et al: Immunohistochemically detected expression of motility-related protein-1 (MRP-1/CD9) in lung adenocarcinoma and its relation to prognosis. Int J Cancer. 74:205–211. 1997. View Article : Google Scholar

14 

De Bruyne E, Bos TJ, Asosingh K, et al: Epigenetic silencing of the tetraspanin CD9 during disease progression in multiple myeloma cells and correlation with survival. Clin Cancer Res. 14:2918–2926. 2008.PubMed/NCBI

15 

De Bruyne E, Andersen TL, De Raeve H, et al: Endothelial cell-driven regulation of CD9 or motility-related protein-1 expression in multiple myeloma cells within the murine 5T33MM model and myeloma patients. Leukemia. 20:1870–1879. 2006.

16 

Fan J, Zhu GZ and Niles RM: Expression and function of CD9 in melanoma cells. Mol Carcinog. 49:85–93. 2010.PubMed/NCBI

17 

Sauer G, Windisch J, Kurzeder C, Heilmann V, Kreienberg R and Deissler H: Progression of cervical carcinomas is associated with down-regulation of CD9 but strong local re-expression at sites of transendothelial invasion. Clin Cancer Res. 9:6426–6431. 2003.

18 

Hori H, Yano S, Koufuji K, Takeda J and Shirouzu K: CD9 expression in gastric cancer and its significance. J Surg Res. 117:208–215. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Horváth G, Serru V, Clay D, Billard M, Boucheix C and Rubinstein E: CD19 is linked to the integrin-associated tetraspans CD9, CD81 and CD82. J Biol Chem. 273:30537–30543. 1998.PubMed/NCBI

20 

Stipp CS, Orlicky D and Hemler ME: FPRP, a major highly stoichiometric, highly specific CD81- and CD9-associated protein. J Biol Chem. 276:4853–4862. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Berditchevski F: Complexes of tetraspanins with integrins: more than meets the eye. J Cell Sci. 114:4143–4151. 2001.PubMed/NCBI

22 

Miyake M, Nakano K, Ieki Y, et al: Motility related protein 1 (MRP-1/CD9) expression: inverse correlation with metastases in breast cancer. Cancer Res. 55:4127–4131. 1995.PubMed/NCBI

23 

Cajot JF, Sordat I, Silvestre T and Sordat B: Differential display cloning identifies motility-related protein (MRP1/CD9) as highly expressed in primary compared to metastatic human colon carcinoma cells. Cancer Res. 57:2593–2597. 1997.

24 

Mimori K, Kataoka A, Yoshinaga K, et al: Identification of molecular markers for metastasis-related genes in primary breast cancer cells. Clin Exp Metastasis. 22:59–67. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Kischel P, Bellahcene A, Deux B, et al: Overexpression of CD9 in human breast cancer cells promotes the development of bone metastases. Anticancer Res. 32:5211–5220. 2012.PubMed/NCBI

26 

Erovic BM, Pammer J, Hollemann D, et al: Motility-related protein-1/CD9 expression in head and neck squamous cell carcinoma. Head Neck. 25:848–857. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Longo N, Yáñez-Mó M, Mittelbrunn M, et al: Regulatory role of tetraspanin CD9 in tumor-endothelial cell interaction during transendothelial invasion of melanoma cells. Blood. 98:3717–3726. 2001. View Article : Google Scholar

28 

Klein-Soyer C, Azorsa DO, Cazenave JP and Lanza F: CD9 participates in endothelial cell migration during in vitro wound repair. Arterioscler Thromb Vasc Biol. 20:360–369. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Iwasaki T, Takeda Y, Maruyama K, et al: Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro. J Biol Chem. 288:2118–2131. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Kamisasanuki T, Tokushige S, Terasaki H, et al: Targeting CD9 produces stimulus-independent antiangiogenic effects predominantly in activated endothelial cells during angiogenesis: a novel antiangiogenic therapy. Biochem Biophys Res Commun. 413:128–135. 2011. View Article : Google Scholar

31 

Hong IK, Kim YM, Jeoung DI, Kim KC and Lee H: Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK, JNK and c-Jun pathways in human melanoma cells. Exp Mol Med. 37:230–239. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Osenkowski P, Toth M and Fridman R: Processing, shedding and endocytosis of membrane type 1-matrix metalloproteinase (MT1-MMP). J Cell Physiol. 200:2–10. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Lafleur MA, Xu D and Hemler ME: Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis. Mol Biol Cell. 20:2030–2040. 2009. View Article : Google Scholar

34 

Richardson MM, Jennings LK and Zhang XA: Tetraspanins and tumor progression. Clin Exp Metastasis. 28:261–270. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Huang CL, Ueno M, Liu D, et al: MRP-1/CD9 gene transduction regulates the actin cytoskeleton through the downregulation of WAVE2. Oncogene. 25:6480–6488. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Takenawa T and Suetsugu S: The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nat Rev Mol Cell Biol. 8:37–48. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Ono M, Handa K, Sonnino S, Withers DA, Nagai H and Hakomori S: GM3 ganglioside inhibits CD9-facilitated haptotactic cell motility: coexpression of GM3 and CD9 is essential in the downregulation of tumor cell motility and malignancy. Biochemistry. 40:6414–6421. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Mitsuzuka K, Handa K, Satoh M, Arai Y and Hakomori S: A specific microdomain (‘glycosynapse 3’) controls phenotypic conversion and reversion of bladder cancer cells through GM3-mediated interaction of alpha3beta1 integrin with CD9. J Biol Chem. 280:35545–35553. 2005.

39 

Rubinstein E, Le Naour F, Billard M, Prenant M and Boucheix C: CD9 antigen is an accessory subunit of the VLA integrin complexes. Eur J Immunol. 24:3005–3013. 1994. View Article : Google Scholar : PubMed/NCBI

40 

Kotha J, Longhurst C, Appling W and Jennings LK: Tetraspanin CD9 regulates beta 1 integrin activation and enhances cell motility to fibronectin via a PI-3 kinase-dependent pathway. Exp Cell Res. 314:1811–1822. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Desgrosellier JS and Cheresh DA: Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer. 10:9–22. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Shattil SJ, Kim C and Ginsberg MH: The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol. 11:288–300. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Pellinen T, Rantala JK, Arjonen A, Mpindi JP, Kallioniemi O and Ivaska J: A functional genetic screen reveals new regulators of beta1-integrin activity. J Cell Sci. 125:649–661. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Chambrion C and Le Naour F: The tetraspanins CD9 and CD81 regulate CD9P1-induced effects on cell migration. PLoS One. 5:e112192010. View Article : Google Scholar : PubMed/NCBI

45 

Castro-Sanchez L, Soto-Guzman A, Navarro-Tito N, Martinez-Orozco R and Salazar EP: Native type IV collagen induces cell migration through a CD9 and DDR1-dependent pathway in MDA-MB-231 breast cancer cells. Eur J Cell Biol. 89:843–852. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Murayama Y, Miyagawa J, Oritani K, et al: CD9-mediated activation of the p46 Shc isoform leads to apoptosis in cancer cells. J Cell Sci. 117:3379–3388. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Zvereff V, Wang JC, Shun K, Lacoste J and Chevrette M: Colocalisation of CD9 and mortalin in CD9-induced mitotic catastrophe in human prostate cancer cells. Br J Cancer. 97:941–948. 2007.PubMed/NCBI

48 

Shallal S and Kornbluth J: CD9 expression enhances the susceptibility of myeloma cell lines to cell-mediated cytolysis. Blood. 96:224–233. 2000.PubMed/NCBI

49 

Murayama Y, Miyagawa J, Shinomura Y, et al: Significance of the association between heparin-binding epidermal growth factor-like growth factor and CD9 in human gastric cancer. Int J Cancer. 98:505–513. 2002. View Article : Google Scholar

50 

Murayama Y, Shinomura Y, Oritani K, et al: The tetraspanin CD9 modulates epidermal growth factor receptor signaling in cancer cells. J Cell Physiol. 216:135–143. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Qi JC, Wang J, Mandadi S, et al: Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor. Blood. 107:135–142. 2006. View Article : Google Scholar : PubMed/NCBI

52 

Atanackovic D, Hildebrandt Y, Templin J, et al: Role of interleukin 16 in multiple myeloma. J Natl Cancer Inst. 104:1005–1020. 2012. View Article : Google Scholar : PubMed/NCBI

53 

Hwang JR, Jo K, Lee Y, Sung BJ, Park YW and Lee JH: Upregulation of CD9 in ovarian cancer is related to the induction of TNF-alpha gene expression and constitutive NF-kappaB activation. Carcinogenesis. 33:77–83. 2012. View Article : Google Scholar : PubMed/NCBI

54 

Kohmo S, Kijima T, Otani Y, et al: Cell surface tetraspanin CD9 mediates chemoresistance in small cell lung cancer. Cancer Res. 70:8025–8035. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Reya T, Morrison SJ, Clarke MF and Weissman IL: Stem cells, cancer and cancer stem cells. Nature. 414:105–111. 2001. View Article : Google Scholar : PubMed/NCBI

56 

Bonnet D and Dick JE: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 3:730–737. 1997. View Article : Google Scholar

57 

Kim YJ, Yu JM, Joo HJ, et al: Role of CD9 in proliferation and proangiogenic action of human adipose-derived mesenchymal stem cells. Pflugers Arch. 455:283–296. 2007. View Article : Google Scholar : PubMed/NCBI

58 

Biermann K, Heukamp LC, Steger K, et al: Gene expression profiling identifies new biological markers of neoplastic germ cells. Anticancer Res. 27:3091–3100. 2007.PubMed/NCBI

59 

Nishida H, Yamazaki H, Yamada T, et al: CD9 correlates with cancer stem cell potentials in human B-acute lymphoblastic leukemia cells. Biochem Biophys Res Commun. 382:57–62. 2009. View Article : Google Scholar : PubMed/NCBI

60 

Yamazaki H, Xu CW, Naito M, et al: Regulation of cancer stem cell properties by CD9 in human B-acute lymphoblastic leukemia. Biochem Biophys Res Commun. 409:14–21. 2011. View Article : Google Scholar : PubMed/NCBI

61 

Ghani FI, Yamazaki H, Iwata S, et al: Identification of cancer stem cell markers in human malignant mesothelioma cells. Biochem Biophys Res Commun. 404:735–742. 2011. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Xuan H, Hu X and Huang J: Role of motility‑related protein‑1 in promoting the development of several types of cancer (Review). Oncol Lett 7: 611-615, 2014.
APA
Xuan, H., Hu, X., & Huang, J. (2014). Role of motility‑related protein‑1 in promoting the development of several types of cancer (Review). Oncology Letters, 7, 611-615. https://doi.org/10.3892/ol.2014.1786
MLA
Xuan, H., Hu, X., Huang, J."Role of motility‑related protein‑1 in promoting the development of several types of cancer (Review)". Oncology Letters 7.3 (2014): 611-615.
Chicago
Xuan, H., Hu, X., Huang, J."Role of motility‑related protein‑1 in promoting the development of several types of cancer (Review)". Oncology Letters 7, no. 3 (2014): 611-615. https://doi.org/10.3892/ol.2014.1786
Copy and paste a formatted citation
x
Spandidos Publications style
Xuan H, Hu X and Huang J: Role of motility‑related protein‑1 in promoting the development of several types of cancer (Review). Oncol Lett 7: 611-615, 2014.
APA
Xuan, H., Hu, X., & Huang, J. (2014). Role of motility‑related protein‑1 in promoting the development of several types of cancer (Review). Oncology Letters, 7, 611-615. https://doi.org/10.3892/ol.2014.1786
MLA
Xuan, H., Hu, X., Huang, J."Role of motility‑related protein‑1 in promoting the development of several types of cancer (Review)". Oncology Letters 7.3 (2014): 611-615.
Chicago
Xuan, H., Hu, X., Huang, J."Role of motility‑related protein‑1 in promoting the development of several types of cancer (Review)". Oncology Letters 7, no. 3 (2014): 611-615. https://doi.org/10.3892/ol.2014.1786
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