Extramedullary hematopoiesis within cystic renal cell carcinoma with oncocytic and chromophobe cell types: A case report

Celik,Betul; Bulut,Tangul; Sedele,Murat; Sezer,Cem; Karakus,Volkan

doi:10.3892/ol.2014.1801

Extramedullary hematopoiesis within cystic renal cell carcinoma with oncocytic and chromophobe cell types: A case report

Authors:
- Betul Celik
- Tangul Bulut
- Murat Sedele
- Cem Sezer
- Volkan Karakus
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Affiliations: Department of Pathology, Antalya Training Hospital, Antalya 07040, Turkey, Department of Hematology, Antalya Training Hospital, Antalya 07040, Turkey
Published online on: January 15, 2014 https://doi.org/10.3892/ol.2014.1801
Pages: 909-913

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Abstract

Extramedullary hematopoiesis (EMH) is a phenomenon in which hematopoietic cells are found in sites other than the bone marrow. It is usually observed in the liver and spleen but may occasionally be found within solid tumors. The current case report presents a 69‑year‑old female patient who presented with a renal cyst. Histopathological examination following surgical removal of the cyst revealed a lining of oncocytic‑ and chromophobe‑type cells with capsular invasion and a mass forming EMH with evident bone trabeculae within the cyst wall. Circulating hematopoietic stem cells in the blood and their colonization within tissues is discussed in the present case report, emphasizing certain types of renal cell carcinoma.

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1	Koch CA, Li CY, Mesa RA and Tefferi A: Nonhepatosplenic extramedullary hematopoiesis: associated diseases, pathology, clinical course, and treatment. Mayo Clin Proc. 78:1223–1233. 2003. View Article : Google Scholar
2	Palatnik A, Narayan R and Walters M: Extramedullary hematopoiesis involving uterus, fallopian tubes, and ovaries, mimicking bilateral tuboovarian abscesses. Int J Gynecol Pathol. 31:584–587. 2012. View Article : Google Scholar
3	Akbulut S, Yavuz R, Akansu B, Sogutcu N, Arikanoglu Z and Basbug M: Ectopic bone formation and extramedullary hematopoiesis in the thyroid gland: report of a case and literature review. Int Surg. 96:260–265. 2011. View Article : Google Scholar
4	Radopoulos D, Tzakas K and Tahmatzopoulos A: A rare case of renal oncocytoma associated with erythrocytosis: case report. BMC Urol. 6:262006. View Article : Google Scholar : PubMed/NCBI
5	Mendt M and Cardier JE: Stromal-derived factor-1 and its receptor, CXCR4, are constitutively expressed by mouse liver sinusoidal endothelial cells: implications for the regulation of hematopoietic cell migration to the liver during extramedullary hematopoiesis. Stem Cells Dev. 21:2142–2151. 2012. View Article : Google Scholar
6	McGee SJ, Havens AM, Shiozawa Y, Jung Y and Taichman RS: Effects of erythropoietin on the bone microenvironment. Growth Factors. 30:22–28. 2012. View Article : Google Scholar : PubMed/NCBI
7	Kumar R, Abbas A, Fausto N and Aster JC: Diseases of white blood cells, lymph nodes, spleen, and thymus. Robbins and Cotran Pathologic Basis of Disease. 8th edition. Saunders Elsevier; Philadelphia, PA: pp. 589–638. 2010
8	Policarpio-Nicolas ML, Bregman SG, Ihsan M and Atkins KA: Mass-forming extramedullary hematopoiesis diagnosed by fine-needle aspiration cytology. Diagn Cytopathol. 34:807–811. 2006. View Article : Google Scholar
9	Lemos LB, Baliga M, Benghuzzi HA and Cason Z: Nodular hematopoiesis of the liver diagnosed by fine-needle aspiration cytology. Diagn Cytopathol. 16:51–54. 1997. View Article : Google Scholar : PubMed/NCBI
10	Broucqsault A, Ouzzane A, Launay D, et al: Renal extramedullary hematopoiesis. Prog Urol. 21:575–579. 2011.(In French).
11	Wiesener MS, Münchenhagen P, Gläser M, et al: Erythropoietin gene expression in renal carcinoma is considerably more frequent than paraneoplastic polycythemia. Int J Cancer. 21:2434–2442. 2007. View Article : Google Scholar
12	Tavian M, Biasch K, Sinka L, Vallet J and Péault B: Embryonic origin of human hematopoiesis. Int J Dev Biol. 54:1061–1065. 2010. View Article : Google Scholar
13	Johns JL and Christopher MM: Extramedullary hematopoiesis: a new look at the underlying stem cell niche, theories of development, and occurrence in animals. Vet Pathol. 49:508–523. 2012. View Article : Google Scholar : PubMed/NCBI
14	Robin C, Bollerot K, Mendes S, et al: Human placenta is a potent hematopoietic niche containing hematopoietic stem and progenitor cells throughout development. Cell Stem Cell. 5:385–395. 2009. View Article : Google Scholar
15	Miyamoto K, Yoshida S, Kawasumi M, et al: Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exp Med. 208:2175–2181. 2011. View Article : Google Scholar : PubMed/NCBI
16	Schepers K, Hsiao EC, Garg T, Scott MJ and Passegué E: Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice. Blood. 120:3425–3435. 2012. View Article : Google Scholar : PubMed/NCBI
17	Li J, Zhao Z, Carter C, Ehrlich LI, Bedford MT and Richie ER: Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development. J Immunol. 190:597–604. 2013. View Article : Google Scholar
18	Wang J and Darvishian F: Extramedullary hematopoiesis in breast after neoadjuvant chemotherapy for breast carcinoma. Ann Clin Lab Sci. 36:475–478. 2006.PubMed/NCBI
19	Han J, Koh YJ, Moon HR, et al: Adipose tissue is an extramedullary reservoir for functional hematopoietic stem and progenitor cells. Blood. 115:957–964. 2010. View Article : Google Scholar
20	Singh P, Kapur K, Singla S and Naz N: Endometrial osseous metaplasia and mature bone formation with extramedullary hematopoiesis. J Hum Reprod Sci. 4:56–57. 2011. View Article : Google Scholar : PubMed/NCBI