Abscopal antitumor immune effects of magnet‑mediated hyperthermia at a high therapeutic temperature on Walker‑256 carcinosarcomas in rats

  • Authors:
    • Hui Wang
    • Li Zhang
    • Yingrui Shi
    • Sara Javidiparsijani
    • Guirong Wang
    • Xiao Li
    • Weiwei Ouyang
    • Jumei Zhou
    • Lingyun Zhao
    • Xiaowen Wang
    • Xiaodong Zhang
    • Fuping Gao
    • Jingshi Liu
    • Junming Luo
    • Jintian Tang
  • View Affiliations

  • Published online on: January 15, 2014     https://doi.org/10.3892/ol.2014.1803
  • Pages: 764-770
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The abscopal effect has previously been described in various tumors and is associated with radiation therapy and hyperthermia, with possible underlying mechanisms explaining each observed case. In the present study, we aimed to investigate the antitumor effects of magnet‑mediated hyperthermia on Walker‑256 carcinosarcomas in rats at two different temperature ranges (42‑46˚C and 50‑55˚C). We also aimed to identify whether a higher therapeutic temperature of magnetic‑mediated hyperthermia improves the abscopal antitumor effects, where localised irradiation of the tumor causes not only the irradiated tumor to shrink, but also tumors located far from the area of irradiation. Following induction of carcinosarcoma in both sides of the body, magnet‑mediated hyperthermia was applied to one side only, leaving the other side as a control. The changes in tumor growth were observed. Our results demonstrated that magnet‑mediated hyperthermia at a higher temperature inhibited the growth of carcinosarcoma at the site of treatment. Furthermore, the growth of the carcinosarcoma on the untreated side was also inhibited. The expression levels of proliferating cell nuclear antigen were decreased in the hyperthermia group, which was more significant in the higher temperature test group. Flow cytometric analysis showed an increased number of CD4‑ and CD8‑positive T cells, and enzyme‑linked immunosorbent assay showed increased levels of interferon‑γ and interleukin‑2 in the higher temperature group. These results suggested that magnet‑mediated hyperthermia at a higher temperature (50‑55˚C) can improve the abscopal antitumor effects and stimulate a greater endogenous immune response in carcinosarcoma‑bearing rats.
View Figures
View References

Related Articles

Journal Cover

2014-March
Volume 7 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Zhang L, Shi Y, Javidiparsijani S, Wang G, Li X, Ouyang W, Zhou J, Zhao L, Wang X, Wang X, et al: Abscopal antitumor immune effects of magnet‑mediated hyperthermia at a high therapeutic temperature on Walker‑256 carcinosarcomas in rats. Oncol Lett 7: 764-770, 2014
APA
Wang, H., Zhang, L., Shi, Y., Javidiparsijani, S., Wang, G., Li, X. ... Tang, J. (2014). Abscopal antitumor immune effects of magnet‑mediated hyperthermia at a high therapeutic temperature on Walker‑256 carcinosarcomas in rats. Oncology Letters, 7, 764-770. https://doi.org/10.3892/ol.2014.1803
MLA
Wang, H., Zhang, L., Shi, Y., Javidiparsijani, S., Wang, G., Li, X., Ouyang, W., Zhou, J., Zhao, L., Wang, X., Zhang, X., Gao, F., Liu, J., Luo, J., Tang, J."Abscopal antitumor immune effects of magnet‑mediated hyperthermia at a high therapeutic temperature on Walker‑256 carcinosarcomas in rats". Oncology Letters 7.3 (2014): 764-770.
Chicago
Wang, H., Zhang, L., Shi, Y., Javidiparsijani, S., Wang, G., Li, X., Ouyang, W., Zhou, J., Zhao, L., Wang, X., Zhang, X., Gao, F., Liu, J., Luo, J., Tang, J."Abscopal antitumor immune effects of magnet‑mediated hyperthermia at a high therapeutic temperature on Walker‑256 carcinosarcomas in rats". Oncology Letters 7, no. 3 (2014): 764-770. https://doi.org/10.3892/ol.2014.1803