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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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2014-April Volume 7 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Rosiglitazone amplifies the sensitivity of docetaxel and reduces the expression of CD44v6

  • Authors:
    • Fahe Ji
    • Dongchu Ma
    • Zhaozhe Liu
    • Xiaodong Xie

  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The General Hospital of Shenyang Military Command, Shenyang, Liaoning 110840, P.R. China
  • Pages: 1284-1288
    |
    Published online on: January 24, 2014
       https://doi.org/10.3892/ol.2014.1824
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Abstract

Breast cancer seriously impairs physical and mental health in females. Currently, with further investigation into drugs, a number of new pharmacological effects have been found that offer new methods for clinical application in the treatment of breast cancer. As a widely used antidiabetic drug, rosiglitazone (Ros) has become well known for its anticancer effects, mediated by the activation of peroxisome proliferator‑activated receptor γ and downregulated expression of the associated invasion gene. The objective of the present study was to investigate the combination of Ros and docetaxel (DOC) and whether DOC has any effect on breast cancer cell lines. The results showed that the combination of Ros and DOC may cooperate to increase anti‑growth efficacy. The additive inhibitory effects on cell proliferation were sequence‑dependent and are not likely to be associated with cell cycle arrest. This suggested that the target activation of associated factors of the signaling pathway by Ros may be a compelling ally in cancer treatment. In addition, evidence was provided for a convergence of Ros and DOC to induce the reduced expression of CD44v6. Future studies are required to confirm which associated gene of Ros is significant in blocking the signaling pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Ji F, Ma D, Liu Z and Xie X: Rosiglitazone amplifies the sensitivity of docetaxel and reduces the expression of CD44v6. Oncol Lett 7: 1284-1288, 2014.
APA
Ji, F., Ma, D., Liu, Z., & Xie, X. (2014). Rosiglitazone amplifies the sensitivity of docetaxel and reduces the expression of CD44v6. Oncology Letters, 7, 1284-1288. https://doi.org/10.3892/ol.2014.1824
MLA
Ji, F., Ma, D., Liu, Z., Xie, X."Rosiglitazone amplifies the sensitivity of docetaxel and reduces the expression of CD44v6". Oncology Letters 7.4 (2014): 1284-1288.
Chicago
Ji, F., Ma, D., Liu, Z., Xie, X."Rosiglitazone amplifies the sensitivity of docetaxel and reduces the expression of CD44v6". Oncology Letters 7, no. 4 (2014): 1284-1288. https://doi.org/10.3892/ol.2014.1824
Copy and paste a formatted citation
x
Spandidos Publications style
Ji F, Ma D, Liu Z and Xie X: Rosiglitazone amplifies the sensitivity of docetaxel and reduces the expression of CD44v6. Oncol Lett 7: 1284-1288, 2014.
APA
Ji, F., Ma, D., Liu, Z., & Xie, X. (2014). Rosiglitazone amplifies the sensitivity of docetaxel and reduces the expression of CD44v6. Oncology Letters, 7, 1284-1288. https://doi.org/10.3892/ol.2014.1824
MLA
Ji, F., Ma, D., Liu, Z., Xie, X."Rosiglitazone amplifies the sensitivity of docetaxel and reduces the expression of CD44v6". Oncology Letters 7.4 (2014): 1284-1288.
Chicago
Ji, F., Ma, D., Liu, Z., Xie, X."Rosiglitazone amplifies the sensitivity of docetaxel and reduces the expression of CD44v6". Oncology Letters 7, no. 4 (2014): 1284-1288. https://doi.org/10.3892/ol.2014.1824
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