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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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2014-April Volume 7 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Aberrant expression of redox protein Ape1 in colon cancer stem cells

  • Authors:
    • Debao Lou
    • Lina Zhu
    • Huawei Ding
    • Hai‑Yan Dai
    • Gang‑Ming Zou

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Shanghai Eighth People's Hospital, Shanghai 200235, P.R. China, Department of Ophthalmology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai 200240, P.R. China
  • Pages: 1078-1082
    |
    Published online on: February 10, 2014
       https://doi.org/10.3892/ol.2014.1864
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Abstract

Ape1 is an important redox protein, essential for specific cytokine‑induced signal transduction. Ape1 signaling is also important in regulating the growth of cancer cells, including colon cancer cells. The present study investigated whether Ape1 signaling plays a role in the regulation of colon cancer stem cell (CCSC) growth. The results showed that Ape1 was aberrantly expressed in CCSCs, as determined by quantitative (q)PCR assay. A laser confocal microscopy assay demonstrated that the Ape1 protein was mainly distributed in the nuclei, but not the cytoplasm, of the CSCs. Treatment of CCSCs with Ape1 redox inhibitor (E3330) significantly affected growth in vitro. In colon cancer xenograft mice, in vivo administration of E3330 enhanced tumor responses to the chemotherapeutic drug, 5‑fluorouracil (5‑FU). Furthermore, the combination of E3330 and 5‑FU evidently increased the cytotoxicity of 5‑FU in CSC growth. In the qPCR assay, the CCSCs were demonstrated to express the dominant ATP-binding cassette sub-family G member 2 (ABC-G2), but not the multidrug resistance 1, genes. Thus, we hypothesized that drug resistance in CCSCs is mediated by ABC‑G2. Since CSCs are involved in cancer metastasis, the Ape1 inhibitor may be a potential agent in the inhibition of colon cancer growth and metastasis.

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Copy and paste a formatted citation
Spandidos Publications style
Lou D, Zhu L, Ding H, Dai HY and Zou GM: Aberrant expression of redox protein Ape1 in colon cancer stem cells. Oncol Lett 7: 1078-1082, 2014.
APA
Lou, D., Zhu, L., Ding, H., Dai, H., & Zou, G. (2014). Aberrant expression of redox protein Ape1 in colon cancer stem cells. Oncology Letters, 7, 1078-1082. https://doi.org/10.3892/ol.2014.1864
MLA
Lou, D., Zhu, L., Ding, H., Dai, H., Zou, G."Aberrant expression of redox protein Ape1 in colon cancer stem cells". Oncology Letters 7.4 (2014): 1078-1082.
Chicago
Lou, D., Zhu, L., Ding, H., Dai, H., Zou, G."Aberrant expression of redox protein Ape1 in colon cancer stem cells". Oncology Letters 7, no. 4 (2014): 1078-1082. https://doi.org/10.3892/ol.2014.1864
Copy and paste a formatted citation
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Spandidos Publications style
Lou D, Zhu L, Ding H, Dai HY and Zou GM: Aberrant expression of redox protein Ape1 in colon cancer stem cells. Oncol Lett 7: 1078-1082, 2014.
APA
Lou, D., Zhu, L., Ding, H., Dai, H., & Zou, G. (2014). Aberrant expression of redox protein Ape1 in colon cancer stem cells. Oncology Letters, 7, 1078-1082. https://doi.org/10.3892/ol.2014.1864
MLA
Lou, D., Zhu, L., Ding, H., Dai, H., Zou, G."Aberrant expression of redox protein Ape1 in colon cancer stem cells". Oncology Letters 7.4 (2014): 1078-1082.
Chicago
Lou, D., Zhu, L., Ding, H., Dai, H., Zou, G."Aberrant expression of redox protein Ape1 in colon cancer stem cells". Oncology Letters 7, no. 4 (2014): 1078-1082. https://doi.org/10.3892/ol.2014.1864
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