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Article

Expression and clinical significance of colorectal cancer stem cell marker EpCAMhigh/CD44+ in colorectal cancer

  • Authors:
    • Dan Liu
    • Jinghua Sun
    • Jinming Zhu
    • Huan Zhou
    • Xian Zhang
    • Yang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China, Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, P.R. China
  • Pages: 1544-1548
    |
    Published online on: February 21, 2014
       https://doi.org/10.3892/ol.2014.1907
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Abstract

Colorectal cancer stem cells are considered the source of recurrence, metastasis and drug resistance in colorectal tumors. Therefore, the identification and targeting of cancer stem cells facilitates the elimination of tumors. Although epithelial cell adhesion molecule‑high (EpCAMhigh)/cluster of differentiation (CD)44+ cells are thought to act as a marker of colorectal cancer stem cells, the clinical significance of these cells in colorectal cancer remains unclear. The aim of the present study was to explore the prevalence and clinical significance of colorectal cancer stem cell marker EpCAMhigh/CD44+ in colorectal cancer. Double immunohistochemical staining was used to detect the expression of EpCAM/CD44 in 80 cases of colorectal cancer and their corresponding liver metastases. The expression of EpCAM/CD44 in colorectal cancer was analyzed, and the correlation of EpCAMhigh/CD44+ with the biological behavior of colorectal cancer was explored. In the 80 cases of colorectal cancer studied, the presence of EpCAMhigh/CD44+ cells had no correlation with gender, patient age or the magnitude of the tumor (P>0.05), but was significantly correlated with degree of differentiation, depth of invasion, clinical stage and metastatic status (P<0.05). In addition, EpCAMhigh/CD44+ cells were detected in the corresponding liver metastases. Thus, the results of this study indicate that EpCAMhigh/CD44+, a marker of colorectal cancer stem cells, is significantly correlated with the invasion and metastases of colorectal cancer.
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1 

Yamaki M, Shinozaki K, Sakaguchi T, Meseck M, Ebert O, Ohdan H and Woo SL: The potential of recombinant vesicular stomatitis virus-mediated virotherapy against metastatic colon cancer. Int J Mol Med. 31:299–306. 2013.

2 

Christ B and Stock P: Mesenchymal stem cell-derived hepatocytes for functional liver replacement. Front Immunol. 3:1682012. View Article : Google Scholar : PubMed/NCBI

3 

Lakowski J, Han YT, Pearson RA, et al: Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression. Stem Cells. 29:1391–1404. 2011.

4 

Dalerba P, Dylla SJ, Park IK, et al: Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA. 104:10158–10163. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Lugli A, Iezzi G, Hostettler I, et al: Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer. Br J Cancer. 103:382–390. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Piscuoglio S, Lehmann FS, Zlobec I, et al: Effect of EpCAM, CD44, CD133 and CD166 expression on patient survival in tumours of the ampulla of Vater. J Clin Pathol. 65:140–145. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Fléjou JF: WHO Classification of digestive tumors: the fourth edition. Ann Pathol. 31:S27–S31. 2011.(In French).

8 

Aust DE: WHO classification 2010 for the lower gastrointestinal tract: what is new? Pathologe. 32:326–331. 2011.(In German).

9 

Lin Y, Zhong Y, Guan H, Zhang X and Sun Q: CD44+/CD24− phenotype contributes to malignant relapse following surgical resection and chemotherapy in patients with invasive ductal carcinoma. J Exp Clin Cancer Res. 31:592012.

10 

Haraguchi N, Inoue H, Tanaka F, et al: Cancer stem cells in human gastrointestinal cancers. Hum Cell. 19:24–29. 2006. View Article : Google Scholar

11 

Sankpal NV, Mayfield JD, Willman MW, Fleming TP and Gillanders WE: Activator protein 1 (AP-1) contributes to EpCAM-dependent breast cancer invasion. Breast Cancer Res. 13:R1242011. View Article : Google Scholar : PubMed/NCBI

12 

Lin CW, Liao MY, Lin WW, Wang YP, Lu TY and Wu HC: Epithelial cell adhesion molecule regulates tumor initiation and tumorigenesis via activating reprogramming factors and epithelial-mesenchymal transition gene expression in colon cancer. J Biol Chem. 287:39449–39459. 2012. View Article : Google Scholar

13 

Gaiser MR, Lämmermann T, Feng X, et al: Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo. Proc Natl Acad Sci USA. 109:E889–E897. 2012. View Article : Google Scholar

14 

Jaggupilli A and Elkord E: Significance of CD44 and CD24 as cancer stem cell markers: an enduring ambiguity. Clin Dev Immunol. 2012:7080362012. View Article : Google Scholar : PubMed/NCBI

15 

Murai T, Maruyama Y, Mio K, Nishiyama H, Suga M and Sato C: Low cholesterol triggers membrane microdomain-dependent CD44 shedding and suppresses tumor cell migration. J Biol Chem. 286:1999–2007. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Zarrabi K, Dufour A, Li J, et al: Inhibition of matrix metalloproteinase 14 (MMP-14)-mediated cancer cell migration. J Biol Chem. 286:33167–33177. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Kemper K, Grandela C and Medema JP: Molecular identification and targeting of colorectal cancer stem cells. Oncotarget. 1:387–395. 2010.PubMed/NCBI

18 

Schulenburg A, Cech P, Herbacek I, Marian B, Wrba F, Valent P and Ulrich-Pur H: CD44-positive colorectal adenoma cells express the potential stem cell markers musashi antigen (msi1) and ephrin B2 receptor (EphB2). J Pathol. 213:152–160. 2007. View Article : Google Scholar

19 

Strauss R, Li ZY, Liu Y, et al: Analysis of epithelial and mesenchymal markers in ovarian cancer reveals phenotypic heterogeneity and plasticity. PLoS One. 6:e161862011. View Article : Google Scholar : PubMed/NCBI

20 

Belov L, Zhou J and Christopherson RI: Cell surface markers in colorectal cancer prognosis. Int J Mol Sci. 12:78–113. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Wang SJ and Bourguignon LY: Role of hyaluronan-mediated CD44 signaling in head and neck squamous cell carcinoma progression and chemoresistance. Am J Pathol. 178:956–963. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Kuhn S, Koch M, Nübel T, et al: A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression. Mol Cancer Res. 5:553–567. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Marhaba R, Klingbeil P, Nuebel T, Nazarenko I, Buechler MW and Zoeller M: CD44 and EpCAM: cancer-initiating cell markers. Curr Mol Med. 8:784–804. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Dylla SJ, Beviglia L, Park IK, et al: Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One. 3:e24282008. View Article : Google Scholar : PubMed/NCBI

25 

Biddle A, Liang X, Gammon L, Fazil B, Harper LJ, Emich H, Costea DE and Mackenzie IC: Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative. Cancer Res. 71:5317–5326. 2011. View Article : Google Scholar

26 

Münz M, Murr A, Kvesic M, et al: Side-by-side analysis of five clinically tested anti-EpCAM monoclonal antibodies. Cancer Cell Int. 10:442010.PubMed/NCBI

27 

Bezan A, Hohla F, Meissnitzer T, et al: Systemic effect of catumaxomab in a patient with metastasized colorectal cancer: a case report. BMC Cancer. 13:6182013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu D, Sun J, Zhu J, Zhou H, Zhang X and Zhang Y: Expression and clinical significance of colorectal cancer stem cell marker EpCAMhigh/CD44+ in colorectal cancer. Oncol Lett 7: 1544-1548, 2014.
APA
Liu, D., Sun, J., Zhu, J., Zhou, H., Zhang, X., & Zhang, Y. (2014). Expression and clinical significance of colorectal cancer stem cell marker EpCAMhigh/CD44+ in colorectal cancer. Oncology Letters, 7, 1544-1548. https://doi.org/10.3892/ol.2014.1907
MLA
Liu, D., Sun, J., Zhu, J., Zhou, H., Zhang, X., Zhang, Y."Expression and clinical significance of colorectal cancer stem cell marker EpCAMhigh/CD44+ in colorectal cancer". Oncology Letters 7.5 (2014): 1544-1548.
Chicago
Liu, D., Sun, J., Zhu, J., Zhou, H., Zhang, X., Zhang, Y."Expression and clinical significance of colorectal cancer stem cell marker EpCAMhigh/CD44+ in colorectal cancer". Oncology Letters 7, no. 5 (2014): 1544-1548. https://doi.org/10.3892/ol.2014.1907
Copy and paste a formatted citation
x
Spandidos Publications style
Liu D, Sun J, Zhu J, Zhou H, Zhang X and Zhang Y: Expression and clinical significance of colorectal cancer stem cell marker EpCAMhigh/CD44+ in colorectal cancer. Oncol Lett 7: 1544-1548, 2014.
APA
Liu, D., Sun, J., Zhu, J., Zhou, H., Zhang, X., & Zhang, Y. (2014). Expression and clinical significance of colorectal cancer stem cell marker EpCAMhigh/CD44+ in colorectal cancer. Oncology Letters, 7, 1544-1548. https://doi.org/10.3892/ol.2014.1907
MLA
Liu, D., Sun, J., Zhu, J., Zhou, H., Zhang, X., Zhang, Y."Expression and clinical significance of colorectal cancer stem cell marker EpCAMhigh/CD44+ in colorectal cancer". Oncology Letters 7.5 (2014): 1544-1548.
Chicago
Liu, D., Sun, J., Zhu, J., Zhou, H., Zhang, X., Zhang, Y."Expression and clinical significance of colorectal cancer stem cell marker EpCAMhigh/CD44+ in colorectal cancer". Oncology Letters 7, no. 5 (2014): 1544-1548. https://doi.org/10.3892/ol.2014.1907
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