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Review Open Access

Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review)

  • Authors:
    • Fei Tan
    • Carol J. Thiele
    • Zhijie Li
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Cell and Molecular Biology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, Research Center for Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
  • Pages: 1333-1340
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    Published online on: February 24, 2014
       https://doi.org/10.3892/ol.2014.1909
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Abstract

The collapsin response mediator proteins (CRMPs) were originally identified as mediators of semaphorin 3A signaling and neuronal differentiation. The CRMP family consists of five homologous cytosolic proteins, CRMP1‑5. Altered expression levels of CRMPs have been observed in several malignant tumors, including lung, breast, colorectal, prostate, pancreatic and neuroendocrine lung cancer. The aim of the current study was to review the recent progress achieved in understanding the association between the different levels of CRMP expression in tumors and their involvement in pathological functions, such as tumor metastasis, disease progression, subtype differentiation and clinical outcome, to address the potential value of CRMPs as biomarkers for the diagnosis and prognosis of cancer patients.
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Copy and paste a formatted citation
Spandidos Publications style
Tan F, Thiele CJ and Li Z: Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review). Oncol Lett 7: 1333-1340, 2014.
APA
Tan, F., Thiele, C.J., & Li, Z. (2014). Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review). Oncology Letters, 7, 1333-1340. https://doi.org/10.3892/ol.2014.1909
MLA
Tan, F., Thiele, C. J., Li, Z."Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review)". Oncology Letters 7.5 (2014): 1333-1340.
Chicago
Tan, F., Thiele, C. J., Li, Z."Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review)". Oncology Letters 7, no. 5 (2014): 1333-1340. https://doi.org/10.3892/ol.2014.1909
Copy and paste a formatted citation
x
Spandidos Publications style
Tan F, Thiele CJ and Li Z: Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review). Oncol Lett 7: 1333-1340, 2014.
APA
Tan, F., Thiele, C.J., & Li, Z. (2014). Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review). Oncology Letters, 7, 1333-1340. https://doi.org/10.3892/ol.2014.1909
MLA
Tan, F., Thiele, C. J., Li, Z."Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review)". Oncology Letters 7.5 (2014): 1333-1340.
Chicago
Tan, F., Thiele, C. J., Li, Z."Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review)". Oncology Letters 7, no. 5 (2014): 1333-1340. https://doi.org/10.3892/ol.2014.1909
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