Open Access

Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review)

  • Authors:
    • Fei Tan
    • Carol J. Thiele
    • Zhijie Li
  • View Affiliations

  • Published online on: February 24, 2014     https://doi.org/10.3892/ol.2014.1909
  • Pages: 1333-1340
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Abstract

The collapsin response mediator proteins (CRMPs) were originally identified as mediators of semaphorin 3A signaling and neuronal differentiation. The CRMP family consists of five homologous cytosolic proteins, CRMP1‑5. Altered expression levels of CRMPs have been observed in several malignant tumors, including lung, breast, colorectal, prostate, pancreatic and neuroendocrine lung cancer. The aim of the current study was to review the recent progress achieved in understanding the association between the different levels of CRMP expression in tumors and their involvement in pathological functions, such as tumor metastasis, disease progression, subtype differentiation and clinical outcome, to address the potential value of CRMPs as biomarkers for the diagnosis and prognosis of cancer patients.
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May-2014
Volume 7 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Tan F, Thiele CJ and Li Z: Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review). Oncol Lett 7: 1333-1340, 2014
APA
Tan, F., Thiele, C.J., & Li, Z. (2014). Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review). Oncology Letters, 7, 1333-1340. https://doi.org/10.3892/ol.2014.1909
MLA
Tan, F., Thiele, C. J., Li, Z."Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review)". Oncology Letters 7.5 (2014): 1333-1340.
Chicago
Tan, F., Thiele, C. J., Li, Z."Collapsin response mediator proteins: Potential diagnostic and prognostic biomarkers in cancers (Review)". Oncology Letters 7, no. 5 (2014): 1333-1340. https://doi.org/10.3892/ol.2014.1909