Langerhans cell histiocytosis misdiagnosed as liver cancer and pituitary tumor in an adult: A case report and brief review of the literature

  • Authors:
    • Jing Ma
    • Yongfang Jiang
    • Xiangyu Chen
    • Guozhong Gong
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  • Published online on: February 28, 2014     https://doi.org/10.3892/ol.2014.1928
  • Pages: 1602-1604
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Abstract

Langerhans cell histiocytosis (LCH) is a rare proliferative disorder in which pathological Langerhans cells accumulate in a variety of organs. LCH usually affects the bone, skin and lymph nodes of children; however, LCH occasionally affects vital organs, including the liver, spleen and pituitary gland. The present study reports a case of an adult LCH patient with marked liver damage, splenomegaly and pituitary damage treated using a new therapeutic strategy. This case was misdiagnosed as liver cancer and pituitary tumor on the basis of abdominal ultrasound, abdominal magnetic resonance imaging (MRI) and head MRI. The final diagnosis was established by identifying the proliferation of cluster of differentiation 1a‑positive LCs in liver tissues. A new regimen of combined 12‑week therapy of prednisolone/desmopressin/vincristine and 10 months of maintenance therapy of prednisolone/vinblastine/6‑mercaptopurine improved symptoms, liver function and blood cell tests.
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May-2014
Volume 7 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ma J, Jiang Y, Chen X and Gong G: Langerhans cell histiocytosis misdiagnosed as liver cancer and pituitary tumor in an adult: A case report and brief review of the literature. Oncol Lett 7: 1602-1604, 2014
APA
Ma, J., Jiang, Y., Chen, X., & Gong, G. (2014). Langerhans cell histiocytosis misdiagnosed as liver cancer and pituitary tumor in an adult: A case report and brief review of the literature. Oncology Letters, 7, 1602-1604. https://doi.org/10.3892/ol.2014.1928
MLA
Ma, J., Jiang, Y., Chen, X., Gong, G."Langerhans cell histiocytosis misdiagnosed as liver cancer and pituitary tumor in an adult: A case report and brief review of the literature". Oncology Letters 7.5 (2014): 1602-1604.
Chicago
Ma, J., Jiang, Y., Chen, X., Gong, G."Langerhans cell histiocytosis misdiagnosed as liver cancer and pituitary tumor in an adult: A case report and brief review of the literature". Oncology Letters 7, no. 5 (2014): 1602-1604. https://doi.org/10.3892/ol.2014.1928