Fermentation supernatants of Lactobacillus delbrueckii inhibit growth of human colon cancer cells and induce apoptosis through a caspase 3‑dependent pathway

Wan,Ying; Xin,Yi; Zhang,Cuili; Wu,Dachang; Ding,Dapeng; Tang,Li; Owusu,Lawrence; Bai,Jing; Li,Weiling

doi:10.3892/ol.2014.1959

May-2014 Volume 7 Issue 5

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May-2014 Volume 7 Issue 5

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Article

Fermentation supernatants of Lactobacillus delbrueckii inhibit growth of human colon cancer cells and induce apoptosis through a caspase 3‑dependent pathway

Authors:
- Ying Wan
- Yi Xin
- Cuili Zhang
- Dachang Wu
- Dapeng Ding
- Li Tang
- Lawrence Owusu
- Jing Bai
- Weiling Li
View Affiliations / Copyright

Affiliations: Department of Biotechnology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Clinical Laboratory Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044, P.R. China
Pages: 1738-1742
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Published online on: March 10, 2014

https://doi.org/10.3892/ol.2014.1959
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Abstract

Probiotic bacteria are known to exert a wide range of beneficial effects on their animal hosts. Therefore, the present study explored the effect of the supernatants obtained from Lactobacillus delbrueckii fermentation (LBF) on colon cancer. The results indicated that the proliferation of LBF solution‑treated colon cancer SW620 cells was arrested and accumulated in the G1 phase in a concentration‑dependent manner. The LBF solution efficiently induced apoptosis through the intrinsic caspase 3‑depedent pathway, with a corresponding decreased expression of Bcl‑2. The activity of matrix metalloproteinase 9, which is associated with the invasion of colon cancer cells, was also decreased in the LBF‑treated cells. In conclusion, the results demonstrate the antitumor effect of LBF in vitro and may contribute to the development of novel therapies for the treatment of colon cancer.

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