Primary gastrointestinal stromal tumor of the prostate: A case report and literature review

Liu,Sulai; Yu,Qiuxia; Han,Weiqing; Qi,Lin; Zu,Xiongbing; Zeng,Fuhua; Xie,Yu; Liu,Jingshi

doi:10.3892/ol.2014.1968

June-2014 Volume 7 Issue 6

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June-2014 Volume 7 Issue 6

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Case Report

Primary gastrointestinal stromal tumor of the prostate: A case report and literature review

Authors:
- Sulai Liu
- Qiuxia Yu
- Weiqing Han
- Lin Qi
- Xiongbing Zu
- Fuhua Zeng
- Yu Xie
- Jingshi Liu
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Affiliations: Department of Urology, Xiangya Hospital, The Central South University, Changsha, Hunan 410008, P.R. China, Department of Rheumatology, Ningbo Medical Center Li Huili Hospital, Ningbo, Zhejiang 315040, P.R. China, Department of Urology, The Affiliated Tumor Hospital of Xiangya Medical School, The Central South University, Changsha, Hunan 410013, P.R. China, Department of Anesthesia, The Affiliated Tumor Hospital of Xiangya Medical School, The Central South University, Changsha, Hunan 410008, P.R. China
Pages: 1925-1929
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Published online on: March 12, 2014

https://doi.org/10.3892/ol.2014.1968
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Abstract

Extragastrointestinal stromal tumors (EGISTs) are relatively rare soft tissue neoplasms arising from the extra gastrointestinal tract. The current study presents a case of primary EGIST of the prostate observed in a 55‑year‑old male. Imaging studies showed a 10x10.5x9.5‑cm prostate mass. On histological observation, the mass was separated from the rectum serosa and exhibited a high mitotic count (8/50 high‑power ﬁelds). The results of immunohistochemical staining showed positive immunoreactivity for cluster of differentiation (CD)117 (c‑kit), CD34 and DOG1 in the tumor. On mutation analysis, loss of heterozygosity of the c‑kit gene was observed in the prostatic EGIST; however, the platelet‑derived growth factor receptor‑α (PDGFRA) gene was considered to be normal. Therefore, as EGIST of the prostate is rare, there is a requirement for the confirmation of the diagnosis to be based on immunohistochemistry and mutation analysis (of c‑kit and PDGFRA).

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1	Mucciarini C, Rossi G, Bertolini F, Valli R, Cirilli C, Rashid I, Marcheselli L, Luppi G and Federico M: Incidence and clinicopathologic features of gastrointestinal stromal tumors. A population-based study. BMC Cancer. 7:2302007. View Article : Google Scholar : PubMed/NCBI
2	Appelman HD: Morphology of gastrointestinal stromal tumors: historical perspectives. J Surg Oncol. 104:874–881. 2011. View Article : Google Scholar : PubMed/NCBI
3	Lee CH, Lin YH, Lin HY, Lee CM and Chu JS: Gastrointestinal stromal tumor of the prostate: a case report and literature review. Hum Pathol. 37:1361–1365. 2006. View Article : Google Scholar : PubMed/NCBI
4	Van der Aa F, Sciot R, Blyweert W, Ost D, Van Poppel H, Van Oosterom A, Debiec-Rychter M and De Ridder D: Gastrointestinal stromal tumor of the prostate. Urology. 65:3882005.PubMed/NCBI
5	Yinghao S, Bo Y and Xiaofeng G: Extragastrointestinal stromal tumor possibly originating from the prostate. Int J Urol. 14:869–871. 2007. View Article : Google Scholar : PubMed/NCBI
6	Anagnostou E, Miliaras D and Panagiotakopoulos V: Diagnosis of gastrointestinal stromal tumor (GIST) on transurethral resection of the prostate: a case report and review of the literature. Int J Surg Pathol. 19:632–636. 2011. View Article : Google Scholar : PubMed/NCBI
7	Herawi M, Montgomery EA and Epstein JI: Gastrointestinal stromal tumors (GISTs) on prostate needle biopsy: A clinicopathologic study of 8 cases. Am J Surg Pathol. 30:1389–1395. 2011. View Article : Google Scholar : PubMed/NCBI
8	Kikuchi H, Yamamoto M, Hiramatsu Y, Baba M, Ohta M, Kamiya K, Tanaka T, Suzuki S, Sugimura H, Kitagawa M, et al: Effect of loss of heterozygosity of the c-kit gene on prognosis after hepatectomy for metastatic liver gastrointestinal stromal tumors. Cancer Sci. 98:1734–1739. 2007. View Article : Google Scholar : PubMed/NCBI
9	Tan CB, Zhi W, Shahzad G and Mustacchia P: Gastrointestinal stromal tumors: a review of case reports, diagnosis, treatment, and future directions. ISRN Gastroenterol. 2012:5959682012.PubMed/NCBI
10	Reith JD, Goldblum JR, Lyles RH and Weiss SW: Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol. 13:577–585. 2000. View Article : Google Scholar : PubMed/NCBI
11	Hansel DE, Herawi M, Montgomery E and Epstein JI: Spindle cell lesions of the adult prostate. Mod Pathol. 20:148–158. 2007. View Article : Google Scholar : PubMed/NCBI
12	Ghobadi A, Kabbani W, Barker B and Dowell JE: Rectal GI stromal tumor mimicking a prostate mass. J Clin Oncol. 25:5827–5828. 2007. View Article : Google Scholar : PubMed/NCBI
13	Yamamoto H, Oda Y, Kawaguchi K, Nakamura N, Takahira T, Tamiya S, Saito T, Oshiro Y, Ohta M, Yao T and Tsuneyoshi M: c-kit and PDGFRA mutations in extragastrointestinal stromal tumor (gastrointestinal stromal tumor of the soft tissue). Am J Surg Pathol. 28:479–488. 2004. View Article : Google Scholar : PubMed/NCBI
14	Dematteo RP, Gold JS, Saran L, Gönen M, Liau KH, Maki RG, Singer S, Besmer P, Brennan MF and Antonescu CR: Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST). Cancer. 112:608–615. 2008. View Article : Google Scholar
15	West RB, Corless CL, Chen X, Rubin BP, Subramanian S, Montgomery K, Zhu S, Ball CA, Nielsen TO, Patel R, et al: The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol. 165:107–113. 2004. View Article : Google Scholar : PubMed/NCBI
16	Miettinen M, Sobin LH and Lasota J: Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am J Surg Pathol. 29:52–68. 2005. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Primary gastrointestinal stromal tumor of the prostate: A case report and literature review

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