Screening and functional analysis of a differential protein profile of human breast cancer

  • Authors:
    • Fu‑Jun Liu
    • Xue‑Bo Wang
    • Ai‑Guo Cao
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  • Published online on: March 18, 2014     https://doi.org/10.3892/ol.2014.1978
  • Pages: 1851-1856
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Abstract

To improve the understanding of the enriched functions of proteins and to identify potential biomarkers in human breast cancer, the present study constructed a differentially expressed protein profile by screening immunohistochemistry maps of human breast cancer proteins. A total of 1,688 proteins were found to be differentially expressed in human breast cancer, including 773 upregulated and 915 downregulated proteins. Of these proteins, secreted and membrane proteins were screened and clustered, and more enriched biological functions and pathways were presented in the upregulated protein profiles. Furthermore, altered serum levels of peroxiredoxin (PRDX)2, PRDX6, cathepsin (CTS)B and CTSD were detected by ELISA assay. The present study provides a novel global mapping of potential breast cancer biomarkers that could be used as background to identify the altered pathways in human breast cancer, as well as potential cancer targets.
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June-2014
Volume 7 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liu FJ, Wang XB and Cao AG: Screening and functional analysis of a differential protein profile of human breast cancer. Oncol Lett 7: 1851-1856, 2014
APA
Liu, F., Wang, X., & Cao, A. (2014). Screening and functional analysis of a differential protein profile of human breast cancer. Oncology Letters, 7, 1851-1856. https://doi.org/10.3892/ol.2014.1978
MLA
Liu, F., Wang, X., Cao, A."Screening and functional analysis of a differential protein profile of human breast cancer". Oncology Letters 7.6 (2014): 1851-1856.
Chicago
Liu, F., Wang, X., Cao, A."Screening and functional analysis of a differential protein profile of human breast cancer". Oncology Letters 7, no. 6 (2014): 1851-1856. https://doi.org/10.3892/ol.2014.1978