High-level C-X-C chemokine receptor type 4 expression correlates with brain-specific metastasis following complete resection of non-small cell lung cancer

Wang,Lunqing; Wang,Zhou; Liu,Xiangyan; Liu,Fanying

doi:10.3892/ol.2014.1979

High-level C-X-C chemokine receptor type 4 expression correlates with brain-specific metastasis following complete resection of non-small cell lung cancer

Authors:
- Lunqing Wang
- Zhou Wang
- Xiangyan Liu
- Fanying Liu
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Affiliations: Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong Univeristy, Jinan, Shandong 250021, P.R. China
Published online on: March 18, 2014 https://doi.org/10.3892/ol.2014.1979
Pages: 1871-1876

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Abstract

Brain-speciﬁc metastasis is one of the primary causes of recurrence following complete resection of non-small cell lung cancer (NSCLC) and the underlying mechanism remains unclear. The present study was designed to investigate the correlation between C-X-C chemokine receptor type 4 (CXCR4) expression and brain-speciﬁc metastasis of NSCLC. Lung cancer tissues from 105 patients who underwent complete tumor resection between January 1998 and June 2008 (sample group, 34 with brain metastasis during the follow-up period; control group 1, 34 without metastasis during the follow-up period; and control group 2, 37 with other organ metastasis, excluding brain metastasis, during the follow-up period) were examined by immunohistochemistry to detect the expression of CXCR4 protein. The differences in CXCR4 expression were compared using McNemar's χ2 test. Estimation of survival was calculated with the Kaplan-Meier method and the statistical differences were analyzed with the log-rank test. Overexpression of CXCR4 protein was observed in 31 (91.2%) NSCLC patients with brain metastasis, which was greater than that observed in the NSCLC patients with other organ metastases (73.0%; P=0.048) and without metastases (14.7%; P<0.001). CXCR4 protein was highly overexpressed in patients with brain‑specific metastasis, which indicated that high-level CXCR4 expression correlates with brain-speciﬁc metastasis of NSCLC.

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