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Case Report

An intraosseous malignant peripheral nerve sheath tumor of the lumbar spine without neurofibromatosis: Case report and review of the literature

  • Authors:
    • Kayo Suzuki
    • Taketoshi Yasuda
    • Takeshi Hori
    • Kenta Watanabe
    • Masahiko Kanamori
    • Tomoatsu Kimura
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama City, Toyoma 939‑0194. Japan, Department of Orthopaedic Surgery, Iiyama Red Cross Hospital, Iiyama City, Nagano 389‑2295, Japan, First Department of Human Science, Faculty of Medicine, University of Toyama, Toyama City, Toyoma 939‑0194, Japan
  • Pages: 1965-1969
    |
    Published online on: March 21, 2014
       https://doi.org/10.3892/ol.2014.1987
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Abstract

A malignant peripheral nerve sheath tumor (MPNST) is defined as any malignant tumor that develops or differentiates from cells in the peripheral nerve sheath. This tumor is commonly associated with neurofibromatosis type 1 (NF1) and previous radiotherapy treatment. Primary intraosseous MPNSTs are extremely rare and a case of the lumbar spine in a patient without NF1 is reported in the present study, with a review of the intraosseous MPNST literature. A 45‑year‑old female presented with a 1‑month history of severe lower back pain and pain radiating to the left leg. A total en bloc spondylectomy of L4 was performed. The postoperative histopathological diagnosis was MPNST with deletion of NF1, confirmed by dual‑color fluorescence in situ hybridization (FISH) analysis. The tumor recurred 1 month following the surgery. Although adjuvant chemotherapy was administered, the patient succumbed due to intramedullary dissemination and carcinomatous meningitis 8 months following the initial consultation. NF1 deletion by FISH analysis may be particularly useful in distinguishing MPNST from other high‑grade malignancies with overlapping morphological features.
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Copy and paste a formatted citation
Spandidos Publications style
Suzuki K, Yasuda T, Hori T, Watanabe K, Kanamori M and Kimura T: An intraosseous malignant peripheral nerve sheath tumor of the lumbar spine without neurofibromatosis: Case report and review of the literature. Oncol Lett 7: 1965-1969, 2014.
APA
Suzuki, K., Yasuda, T., Hori, T., Watanabe, K., Kanamori, M., & Kimura, T. (2014). An intraosseous malignant peripheral nerve sheath tumor of the lumbar spine without neurofibromatosis: Case report and review of the literature. Oncology Letters, 7, 1965-1969. https://doi.org/10.3892/ol.2014.1987
MLA
Suzuki, K., Yasuda, T., Hori, T., Watanabe, K., Kanamori, M., Kimura, T."An intraosseous malignant peripheral nerve sheath tumor of the lumbar spine without neurofibromatosis: Case report and review of the literature". Oncology Letters 7.6 (2014): 1965-1969.
Chicago
Suzuki, K., Yasuda, T., Hori, T., Watanabe, K., Kanamori, M., Kimura, T."An intraosseous malignant peripheral nerve sheath tumor of the lumbar spine without neurofibromatosis: Case report and review of the literature". Oncology Letters 7, no. 6 (2014): 1965-1969. https://doi.org/10.3892/ol.2014.1987
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki K, Yasuda T, Hori T, Watanabe K, Kanamori M and Kimura T: An intraosseous malignant peripheral nerve sheath tumor of the lumbar spine without neurofibromatosis: Case report and review of the literature. Oncol Lett 7: 1965-1969, 2014.
APA
Suzuki, K., Yasuda, T., Hori, T., Watanabe, K., Kanamori, M., & Kimura, T. (2014). An intraosseous malignant peripheral nerve sheath tumor of the lumbar spine without neurofibromatosis: Case report and review of the literature. Oncology Letters, 7, 1965-1969. https://doi.org/10.3892/ol.2014.1987
MLA
Suzuki, K., Yasuda, T., Hori, T., Watanabe, K., Kanamori, M., Kimura, T."An intraosseous malignant peripheral nerve sheath tumor of the lumbar spine without neurofibromatosis: Case report and review of the literature". Oncology Letters 7.6 (2014): 1965-1969.
Chicago
Suzuki, K., Yasuda, T., Hori, T., Watanabe, K., Kanamori, M., Kimura, T."An intraosseous malignant peripheral nerve sheath tumor of the lumbar spine without neurofibromatosis: Case report and review of the literature". Oncology Letters 7, no. 6 (2014): 1965-1969. https://doi.org/10.3892/ol.2014.1987
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