Detection of circulating tumor cells in the cerebrospinal fluid of a patient with a solitary metastasis from breast cancer: A case report
- Authors:
- Akshal S. Patel
- Joshua E. Allen
- David T. Dicker
- Jonas M. Sheehan
- Michael J. Glantz
- Wafik S. El‑Deiry
View Affiliations
Affiliations: Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Medicine (Hematology/Oncology), Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA, Department of Neurological Surgery, Penn State Hershey Medical Center, Hershey, PA 17033, USA
- Published online on: March 24, 2014 https://doi.org/10.3892/ol.2014.1993
-
Pages:
2110-2112
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
Brain lesions identified following the diagnosis and eradication of primary cancers are often ambiguous in origin, existing as a solitary metastasis or an independent primary brain tumor. The brain is a relatively common site of metastasis with breast cancer, although determining whether metastases have originated from the breast or brain is often not possible without invasive biopsies. In the current case report, a patient presented with a brain lesion identified by radiography and was without systemic disease. The patient had previously exhibited a complete response to chemotherapy and surgery for a poorly differentiated invasive ductal carcinoma. The origin of the brain lesion could not be determined by magnetic resonance imaging, giving rise to a diagnostic dilemma with diverging treatment options. We previously reported a method to isolate and enumerate tumor cells of epithelial origin in the cerebrospinal fluid (CSF). CSF tumor cell analysis of the patient revealed massive CSF tumor cell burden of epithelial origin, indicating that the brain lesion was likely of breast origin. The current case report highlights the use of CSF tumor cell detection as a differential diagnostic tool, in addition to its previously demonstrated use as a marker of disease burden and therapeutic response.
View References
|
1
|
Louis D, Ohgaki H, Wiestler O, et al: The
2007 WHO classification of tumours of the central nervous system.
Acta Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Ohgaki H and Kleihues P: Genetic pathways
to primary and secondary glioblastoma. Am J Pathol. 170:1445–1453.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Martinez R and Esteller M: The DNA
methylome of glioblastoma multiforme. Neurobiol Dis. 39:40–46.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Weller M, Stupp R, Reifenberger G, et al:
MGMT promoter methylation in malignant gliomas: ready for
personalized medicine? Nat Rev Neurol. 6:39–51. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Ammirati M, Vick N, Liao YL, Ciric I and
Mikhael M: Effect of the extent of surgical resection on survival
and quality of life in patients with supratentorial glioblastomas
and anaplastic astrocytomas. Neurosurgery. 21:201–206. 1987.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Kelly PJ and Hunt C: The limited value of
cytoreductive surgery in elderly patients with malignant gliomas.
Neurosurgery. 34:62–67. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Bindal RK, Sawaya R, Leavens ME and Lee
JJ: Surgical treatment of multiple brain metastases. J Neurosurg.
79:210–216. 1993. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Brown PD, Brown CA, Pollock BE, Gorman DA
and Foote RL: Stereotactic radiosurgery for patients with
‘radioresistant’ brain metastases. Neurosurgery. 51:656–667.
2002.
|
|
9
|
Albiges L, André F, Balleyguier C,
Gomez-Abuin G, Chompret A and Delaloge S: Spectrum of breast cancer
metastasis in BRCA1 mutation carriers: highly increased incidence
of brain metastases. Ann Oncol. 16:1846–1847. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Graesslin O, Abdulkarim BS, Coutant C, et
al: Nomogram to predict subsequent brain metastasis in patients
with metastatic breast cancer. J Clin Oncol. 28:2032–2037. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Patel AS, Allen JE, Dicker DT, et al:
Identification and enumeration of circulating tumor cells in the
cerebrospinal fluid of breast cancer patients with central nervous
system metastases. Oncotarget. 2:752–760. 2011.PubMed/NCBI
|
|
12
|
Fidler IJ: The pathogenesis of cancer
metastasis: the ‘seed and soil’ hypothesis revisited. Nat Rev
Cancer. 3:453–458. 2003.
|
|
13
|
Allen JE and El-Deiry WS: Circulating
tumor cells and colorectal cancer. Curr Colorectal Cancer Rep.
6:212–220. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Cristofanilli M, Hayes DF, Budd GT, et al:
Circulating tumor cells: A novel prognostic factor for newly
diagnosed metastatic breast cancer. J Clin Oncol. 23:1420–1430.
2005. View Article : Google Scholar : PubMed/NCBI
|
