Autologous bone marrow stem cell transplantation for the treatment of postoperative hand infection with a skin defect in diabetes mellitus: A case report

Liu,Yihong; Liu,Yuchen; Wang,Pujie; Tian,Haoming; Ai,Jianzhong; Liu,Yangbo; Zhou,Yi; Liu,Zhongwen; Guo,Wenjun; Yang,Shenke

doi:10.3892/ol.2014.1998

Autologous bone marrow stem cell transplantation for the treatment of postoperative hand infection with a skin defect in diabetes mellitus: A case report

Authors:
- Yihong Liu
- Yuchen Liu
- Pujie Wang
- Haoming Tian
- Jianzhong Ai
- Yangbo Liu
- Yi Zhou
- Zhongwen Liu
- Wenjun Guo
- Shenke Yang
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Affiliations: Department of Endocrinology and Metabolism, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Diabetic Centre of Control and Prevention, The People's Liberation Army 520 Hospital, Mianyang, Sichuan 621000, P.R. China, Core Facility of Genetically Engineered Mice, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China
Published online on: March 24, 2014 https://doi.org/10.3892/ol.2014.1998
Pages: 1857-1862

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Abstract

Among stem cells, autologous mesenchymal stem cells (MSCs) are ideal for transplantation by virtue of limited rejection reactions and marked proliferative ability. This study presents a novel method by which MSCs were harvested from the bone marrow of a patient who presented with severe post‑traumatic infection and a non‑healing skin defect in the hand, secondary to uncontrolled diabetes mellitus (DM). An autologous MSC suspension was injected into the persistent skin defect after stabilizing the blood glucose level and appropriate infection control. During the course of a regular 18‑month postoperative follow‑up, the patient exhibited immediate recovery with no transplant‑associated complications, as well as no evidence of tumorigenicity. Thus, transplantation of autologous MSCs may play a role in the clinical application of stem cells, particularly for treatment of skin defects following surgery in cases of DM and for those caused by various other traumas.

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