Benefits of skin biopsy of senile hemangioma in intravascular large B‑cell lymphoma: A case report and review of the literature

Adachi,Yasushi; Kosami,Koki; Mizuta,Noritoshi; Ito,Mitsuhiro; Matsuoka,Yuki; Kanata,Mami; Akiyama,Hajime; Murao,Tomoko; Li,Ming; Ieki,Ryuji; Ikehara,Susumu

doi:10.3892/ol.2014.2017

June-2014 Volume 7 Issue 6

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June-2014 Volume 7 Issue 6

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Case Report

Benefits of skin biopsy of senile hemangioma in intravascular large B‑cell lymphoma: A case report and review of the literature

Authors:
- Yasushi Adachi
- Koki Kosami
- Noritoshi Mizuta
- Mitsuhiro Ito
- Yuki Matsuoka
- Mami Kanata
- Hajime Akiyama
- Tomoko Murao
- Ming Li
- Ryuji Ieki
- Susumu Ikehara
View Affiliations / Copyright

Affiliations: Division of Surgical Pathology, Toyooka Hospital, Toyooka City, Hyogo 668‑8501, Japan, Department of Internal General Medicine, Toyooka Hospital, Toyooka City, Hyogo 668‑8501, Japan, Division of Medical Biophysics, Kobe University Graduate School of Health Sciences, Kobe City, Hyogo 650‑0017, Japan, Department of Internal Medicine, Public Muraoka Hospital, Kami‑Cho, Hyogo 667‑1311, Japan, Department of Dermatology, Toyooka Hospital, Toyooka City, Hyogo 668‑8501, Japan, Department of Clinical Laboratory, Toyooka Hospital, Toyooka City, Hyogo 668‑8501, Japan, Department of Stem Cell Disorders, Kansai Medical University, Hirakata City, Osaka 573‑1010, Japan
Pages: 2003-2006
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Published online on: March 31, 2014

https://doi.org/10.3892/ol.2014.2017
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Abstract

Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of B-cell lymphoma characterized by selective growth of clonal B-cells in the lumen of the small vessels of various organs including the liver, spleen, lungs, skin, brain, and kidney. An 86-year-old male presented with weight loss, fever and night sweats (known as B symptoms). Blood examination revealed pancytopenia, high lactate dehydrogenase and high soluble interleukin‑2 receptor, suggesting hematopoietic malignancy. However, there were no abnormal hematopoietic cells in the peripheral blood. No lymph node swelling was identified on examination by whole‑body computed tomography scan. Therefore, IVLBCL was suspected, and random skin biopsies and a skin biopsy from a senile hemangioma were carried out. A small number of large atypical lymphoid cells resided in the small blood vessels in the deep dermis and subcutaneous tissue of the random skin biopsies, and numerous atypical lymphoid cells were identified in the small vessels of the senile hemangioma. These results suggest the usefulness of skin biopsy from senile hemangiomas in the diagnosis of IVLBCL.

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1	Willemze R, Jaffe ES, Burg G, et al: WHO-EORTC classification for cutaneous lymphomas. Blood. 105:3768–3785. 2005. View Article : Google Scholar : PubMed/NCBI
2	Zuckerman D, Seliem R and Hochberg E: Intravascular lymphoma: the oncologist’s ‘great imitator’. Oncologist. 11:496–502. 2006.
3	Pfleger L and Tappeiner J: On the recognition of systematized endotheliomatosis of the cutaneous blood vessels (reticuloendotheliosis? Hautarzt. 10:359–363. 1959.(In German).
4	Murase T, Yamaguchi M, Suzuki R, et al: Intravascular large B-cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5. Blood. 109:478–485. 2007. View Article : Google Scholar : PubMed/NCBI
5	Shimada K, Kinoshita T, Naoe T and Nakamura S: Presentation and management of intravascular large B-cell lymphoma. Lancet Oncol. 10:895–902. 2009. View Article : Google Scholar : PubMed/NCBI
6	Asada N, Odawara J, Kimura S, et al: Use of random skin biopsy for diagnosis of intravascular large B-cell lymphoma. Mayo Clin Proc. 82:1525–1527. 2007. View Article : Google Scholar : PubMed/NCBI
7	Ishida M, Hotta M, Hodohara K, Okabe H, et al: A case of intravascular large B-cell lymphoma colonizing in senile hemangioma. J Cutan Pathol. 38:251–253. 2011. View Article : Google Scholar : PubMed/NCBI
8	Ferreri AJ, Campo E, Seymour JF, et al: Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the ‘cutaneous variant’. Br J Haematol. 127:173–183. 2004.PubMed/NCBI
9	Pusch G, Feher G, Szomor A, Kover F, Gomori E and Illes Z: Intravascular lymphoma presenting with neurological signs but diagnosed by prostate biopsy: suspicion as a key to early diagnosis. Eur J Neurol. 16:e39–e41. 2009. View Article : Google Scholar
10	Van Droogenbroeck J, Altintas S, Pollefliet C, Schroyens W and Berneman Z: Intravascular large B-cell lymphoma or intravascular lymphomatosis: report of a case diagnosed by testicle biopsy. Ann Hematol. 80:316–318. 2001.
11	Baumann TP, Hurwitz N, Karamitopolou-Diamantis E, et al: Diagnosis and treatment of intravascular lymphomatosis. Arch Neurol. 57:374–377. 2000. View Article : Google Scholar
12	DiGiuseppe JA, Nelson WG, Seifter EJ, Boitnott JK and Mann RB: Intravascular lymphomatosis: a clinicopathologic study of 10 cases and assessment of response to chemotherapy. J Clin Oncol. 12:2573–2579. 1994.PubMed/NCBI
13	Axelsen RA, Laird PP and Horn M: Intravascular large cell lymphoma: diagnosis on renal biopsy. Pathology. 23:241–243. 1991. View Article : Google Scholar : PubMed/NCBI
14	Le EN, Gerstenblith MR, Gelber AC, et al: The use of blind skin biopsy in the diagnosis of intravascular B-cell lymphoma. J Am Acad Dermato. 59:148–151. 2008. View Article : Google Scholar : PubMed/NCBI
15	Kasuya A, Hashizume H and Takigawa M: Early diagnosis of recurrent diffuse large B-cell lymphoma showing intravascular lymphoma by random skin biopsy. J Dermatol. 38:571–574. 2011. View Article : Google Scholar : PubMed/NCBI
16	Ikoma N, Manabe Y, Yamaoka H, et al: Random skin biopsy of intravascular large B-cell lymphoma: a case report. Tokai J Exp Clin Med. 37:75–76. 2012.PubMed/NCBI
17	Lee BS, Frankfort BJ, Eberhart CG and Weinberg RS: Diagnosis of intravascular lymphoma by a novel biopsy site. Ophthalmology. 118:586–590. 2011. View Article : Google Scholar : PubMed/NCBI
18	Shimada K, Matsue K, Yamamoto K, et al: Retrospective analysis of intravascular large B-cell lymphoma treated with rituximab-containing chemotherapy as reported by the IVL study group in Japan. J Clin Oncol. 26:3189–3195. 2008. View Article : Google Scholar
19	Ishida M, Hodohara K, Yoshida T and Okabe H: Intravascular large B-cell lymphoma colonizing in senile hemangioma: a case report and proposal of possible diagnostic strategy for intravascular lymphoma. Pathol Int. 61:555–557. 2011. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Benefits of skin biopsy of senile hemangioma in intravascular large B‑cell lymphoma: A case report and review of the literature

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