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Article

Hypertrophic pulmonary osteoarthropathy with primary lung cancer

  • Authors:
    • Xinyu Qian
    • Jing Qin
  • View Affiliations / Copyright

    Affiliations: Department of Chemotherapy, Hangzhou First People's Hospital, Hangzhou Cancer Hospital, Hangzhou, Zhejiang 310002, P.R. China, Department of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
  • Pages: 2079-2082
    |
    Published online on: April 2, 2014
       https://doi.org/10.3892/ol.2014.2022
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Abstract

Hypertrophic pulmonary osteoarthropathy (HPO) is a rare paraneoplastic syndrome that is frequently associated with lung cancer; however, the incidence of clinically apparent HPO is not well known. The clinical data of 6,151 patients with advanced lung cancer between January 1996 and December 2008 were retrospectively analyzed in Zhejiang Cancer Hospital (Hangzhou, China). Data pertaining to the presentation of HPO, diagnosis, treatment, pathology, follow‑up and clinical course were documented. HPO was confirmed using bone scintigraphy by the identification of symmetrical, abnormally high uptake in the joints, and/or long bones with digital clubbing in the extremities as well as joint pain. The clinical characteristics were investigated based on clinical and pathological records. The patients were presenting with lung cancer for the first time and had not received treatment. Among the 6,151 lung cancer patients, 115 (1.87%) demonstrated an abnormally high uptake on bone scintigraphy and digital clubbing in the extremities combined with joint pain. A total of 109 patients received surgery or chemotherapy treatment and 92 exhibited improved symptoms. The improvement rate of HPO was lower in the non‑surgery compared with the surgery patients (77.4 vs. 91.1%; P=0.049). Bone scintigraphy was repeated in 85 patients within 3‑6 months, and the HPO symptoms improved in 70 patients. The present retrospective study indicated that 1.87% of patients with lung cancer showed characteristics that were identified as HPO. The majority of the patient symptoms and the bone scintigram of HPO improved as a result of treatment.
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1 

Bamberger E: Sitzung der K. K. Ges. der Aerzte in Wien, 8 März 1889. Wien Klin Wschr. 2:2261889.

2 

Yeung SC, Habra MA and Thosani SN: Lung cancer-induced paraneoplastic syndromes. Curr Opin Pulm Med. 17:260–268. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Myers KA and Farquhar DR: The rational clinical examination. Does this patient have clubbing? JAMA. 286:341–347. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Armstrong DJ, McCausland EM and Wright GD: Hypertrophic pulmonary osteoarthropathy (HPOA) (Pierre Marie-Bamberger syndrome): two cases presenting as acute in inflammatory arthritis. Description and review of the literature. Rheumatol Int. 27:399–402. 2007. View Article : Google Scholar

5 

Ray RS and Fisher HP Jr: Hypertrophic osteoarthropathy in pulmonary malignancies. Ann Intern Med. 38:239–246. 1953. View Article : Google Scholar : PubMed/NCBI

6 

Segal AM and Mackenzie AH: Hypertrophic osteoarthropathy: a 10-year retrospective analysis. Semin Arthritis Rheum. 12:220–232. 1982.PubMed/NCBI

7 

Coury C: Hippocration fingers and hypertrophic osteoarthropathy. A study of 350 cases. Br J Dis Chest. 54:202–209. 1960. View Article : Google Scholar : PubMed/NCBI

8 

Martinez-Lavin M: Hypertrophic osteoarthropathy. Primer on the Rheumatic Diseases. Klippel JH: 12th ed. The Arthritis Foundation; Atlanta, GA: pp. 493–495. 2001

9 

Katsuyama N, Yamaguchi K and Takano H: A case of hypertrophic osteoarthropathy secondary to lung cancer. Rinsho Hoshasen. 33:1117–1118. 1988.(In Japanese).

10 

Kroon HM and Pauwels EK: Bone scintigraphy for the detection and follow-up of hypertrophic osteoarthropathy. Diagn Imaging. 51:47–55. 1982.PubMed/NCBI

11 

Hirakata Y and Kitamura S: Pulmonary hypertrophic osteoarthropathy and clubbing of fingers in patients with lung cancer. Nihon Kyobu Shikkan Gakkai Zasshi. 33:1080–1085. 1995.(In Japanese).

12 

Sato K, Iwasaki Y, Kobayashi G, et al: Pulmonary hypertrophic osteoarthropathy associated with primary lung cancer. Nihon Kokyuki Gakkai Zasshi. 38:73–77. 2000.(In Japanese).

13 

Honma H: Etiology of pulmonary hypertrophic osteoarthropathy. Nihon Rinsho. 33:392–397. 1975.(In Japanese).

14 

Rami-Porta R, Ball D, Crowley J, et al; International Staging Committee; Cancer Research and Biostatistics; Observers to the Committe; Participating Institutions. The IASLC Lung Cancer Staging Project: proposals for the revision of the T descriptors in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol. 2:593–602. 2007. View Article : Google Scholar

15 

Oken MM, Creech RH, Tormey DC, et al: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 5:649–655. 1982. View Article : Google Scholar : PubMed/NCBI

16 

Morgan B, Coakley F, Finlay DB and Belton I: Hypertrophic osteoarthropathy in staging skeletal scintigraphy for lung cancer. Clin Radiol. 51:694–647. 1996. View Article : Google Scholar : PubMed/NCBI

17 

Ito T, Goto K, Yoh K, et al: Hypertrophic pulmonary osteoarthropathy as a paraneoplastic manifestation of lung cancer. J Thorac Oncol. 5:976–980. 2010.PubMed/NCBI

18 

Izumi M, Takayama K, Yabuuchi H, et al: Incidence of hypertrophic pulmonary osteoarthropathy associated with primary lung cancer. Respirology. 15:809–812. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Albrecht S and Keller A: Postchemotherapeutic reversibility of hypertrophic osteoarthropathy in a patient with bronchogenic adenocarcinoma. Clin Nucl Med. 28:463–466. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Uchisako H, Suga K, Tanaka N, et al: Bone scintigraphy in growth hormone-secreting pulmonary cancer and hypertrophic osteoarthropathy. J Nucl Med. 36:822–825. 1995.PubMed/NCBI

21 

Mito K, Maruyama R, Uenishi Y, et al: Hypertrophic pulmonary osteoarthropathy associated with non-small cell lung cancer demonstrated growth hormone-releasing hormone by immunohistochemical analysis. Intern Med. 40:532–535. 2001. View Article : Google Scholar

22 

Faiman C, Colwell JA, Ryan RJ, et al: Gonadotropin secretion from a bronchogenic carcinoma. Demonstration by radioimmunoassay. N Engl J Med. 277:1395–1399. 1967. View Article : Google Scholar : PubMed/NCBI

23 

Nomori H, Kobayashi R, Kubo A, et al: Lung cancer containing growth hormone-releasing hormone associated with hypertrophic osteoarthropathy. Case report. Scand J Thorac Cardiovasc Surg. 28:149–152. 1994. View Article : Google Scholar : PubMed/NCBI

24 

Dickinson CJ and Martin JF: Megakaryocytes and platelet clumps as the cause of finger clubbing. Lancet. 2:1434–1435. 1987. View Article : Google Scholar : PubMed/NCBI

25 

Uppal S, Diggle CP, Carr IM, et al: Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy. Nature Genet. 40:789–793. 2008. View Article : Google Scholar

26 

Holling HE, Danielson GK, Hamilton RW, et al: Hypertrophic pulmonary osteoarthropathy. J Thorac Cardiovasc Surg. 46:310–321. 1963.

27 

Kishi K, Nakamura H, Sudo A, et al: Tumor debulking by radiofrequency ablation in hypertrophic pulmonary osteoarthropathy associated with pulmonary carcinoma. Lung Cancer. 38:317–320. 2002. View Article : Google Scholar

28 

Abe Y, Kurita S, Ohkubo Y, et al: A case of pulmonary adenocarcinima associated with hypertrophic osteoarthropathy due to vascular endothelial growth factor. Anticancer Res. 22:3485–3458. 2002.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qian X and Qin J: Hypertrophic pulmonary osteoarthropathy with primary lung cancer. Oncol Lett 7: 2079-2082, 2014.
APA
Qian, X., & Qin, J. (2014). Hypertrophic pulmonary osteoarthropathy with primary lung cancer. Oncology Letters, 7, 2079-2082. https://doi.org/10.3892/ol.2014.2022
MLA
Qian, X., Qin, J."Hypertrophic pulmonary osteoarthropathy with primary lung cancer". Oncology Letters 7.6 (2014): 2079-2082.
Chicago
Qian, X., Qin, J."Hypertrophic pulmonary osteoarthropathy with primary lung cancer". Oncology Letters 7, no. 6 (2014): 2079-2082. https://doi.org/10.3892/ol.2014.2022
Copy and paste a formatted citation
x
Spandidos Publications style
Qian X and Qin J: Hypertrophic pulmonary osteoarthropathy with primary lung cancer. Oncol Lett 7: 2079-2082, 2014.
APA
Qian, X., & Qin, J. (2014). Hypertrophic pulmonary osteoarthropathy with primary lung cancer. Oncology Letters, 7, 2079-2082. https://doi.org/10.3892/ol.2014.2022
MLA
Qian, X., Qin, J."Hypertrophic pulmonary osteoarthropathy with primary lung cancer". Oncology Letters 7.6 (2014): 2079-2082.
Chicago
Qian, X., Qin, J."Hypertrophic pulmonary osteoarthropathy with primary lung cancer". Oncology Letters 7, no. 6 (2014): 2079-2082. https://doi.org/10.3892/ol.2014.2022
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