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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Capillary morphogenesis gene 2 regulates adhesion and invasiveness of prostate cancer cells

  • Authors:
    • Lin Ye
    • Andrew J. Sanders
    • Ping‑Hui Sun
    • Malcolm D. Mason
    • Wen G. Jiang
  • View Affiliations / Copyright

    Affiliations: Metastasis and Angiogenesis Research Group, Institute of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, UK
  • Pages: 2149-2153
    |
    Published online on: April 4, 2014
       https://doi.org/10.3892/ol.2014.2038
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Abstract

Capillary morphogenesis gene 2 (CMG2), also known as anthrax toxin receptor 2, has been indicated in the formation of new vasculature and in the internalisation of the anthrax toxin. Anti‑angiogenesis therapy that targets this molecule has been investigated. However, our recent studies of this molecule have indicated that this gene may also play certain roles in cancer cells. The present study aimed to examine the expression of CMG2 in prostate cancer tissues and cell lines, and also its impact on cellular functions. The expression of CMG2 was detectable in normal and prostate cancer tissues. The prostate cancer cell lines appeared to have relatively high expression compared with the prostatic epithelial cells. Knockdown of CMG2 impaired the adherence of the prostate cancer cells. CMG2 overexpression resulted in decreasing invasiveness, while the knockdown of CMG2 contrastingly enhanced this ability. The altered expression of CMG2 in the prostate cancer cells did not affect the in vitro or in vivo growth of the cells. Taken together, these results show that CMG2 is expressed in prostatic epithelia and cancer cells. In addition to its role in the angiogenesis and the internalisation of anthrax toxin, CMG2 also plays an important role in regulating the adhesion and invasion of prostate cancer cells.
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1 

Cancer Research UK. Numbers of cases and deaths. http://www.cancerresearchuk.org/cancer-info/cancerstats/mort-ality/uk-cancer-mortality-statistics. Accessed August 6, 2013

2 

Mason MD, Davies G and Jiang WG: Cell adhesion molecules and adhesion abnormalities in prostate cancer. Crit Rev Oncol Hematol. 41:11–28. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Harrison GM, Davies G, Martin TA, Jiang WG and Mason MD: Distribution and expression of CD44 isoforms and Ezrin during prostate cancer-endothelium interaction. Int J Oncol. 21:935–940. 2002.PubMed/NCBI

4 

Johnson TR, Khandrika L, Kumar B, et al: Focal adhesion kinase controls aggressive phenotype of androgen-independent prostate cancer. Mol Cancer Res. 6:1639–1648. 2008. View Article : Google Scholar

5 

Bell SE, Mavila A, Salazar R, et al: Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. J Cell Sci. 114:2755–2773. 2001.

6 

Scobie HM, Rainey GJ, Bradley KA and Young JA: Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc Natl Acad Sci USA. 100:5170–5174. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Bradley KA, Mogridge J, Mourez M, Collier RJ and Young JA: Identification of the cellular receptor for anthrax toxin. Nature. 414:225–229. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Dowling O, Difeo A, Ramirez MC, et al: Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet. 73:957–966. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Hanks S, Adams S, Douglas J, et al: Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet. 73:791–800. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Reeves CV, Dufraine J, Young JA and Kitajewski J: Anthrax toxin receptor 2 is expressed in murine and tumor vasculature and functions in endothelial proliferation and morphogenesis. Oncogene. 29:789–801. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Antaya RJ, Cajaiba MM, Madri J, et al: Juvenile hyaline fibromatosis and infantile systemic hyalinosis overlap associated with a novel mutation in capillary morphogenesis protein-2 gene. Am J Dermatopathol. 29:99–103. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Hatamochi A, Sasaki T, Kawaguchi T, Suzuki H and Yamazaki S: A novel point mutation in the gene encoding capillary morphogenesis protein 2 in a Japanese patient with juvenile hyaline fibromatosis. Br J Dermatol. 157:1037–1039. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Whittaker CA and Hynes RO: Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. Mol Biol Cell. 13:3369–3387. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Reeves CV, Wang X, Charles-Horvath PC, et al: Anthrax toxin receptor 2 functions in ECM homeostasis of the murine reproductive tract and promotes MMP activity. PLoS One. 7:e348622012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ye L, Sanders AJ, Sun PH, Mason MD and Jiang WG: Capillary morphogenesis gene 2 regulates adhesion and invasiveness of prostate cancer cells. Oncol Lett 7: 2149-2153, 2014.
APA
Ye, L., Sanders, A.J., Sun, P., Mason, M.D., & Jiang, W.G. (2014). Capillary morphogenesis gene 2 regulates adhesion and invasiveness of prostate cancer cells. Oncology Letters, 7, 2149-2153. https://doi.org/10.3892/ol.2014.2038
MLA
Ye, L., Sanders, A. J., Sun, P., Mason, M. D., Jiang, W. G."Capillary morphogenesis gene 2 regulates adhesion and invasiveness of prostate cancer cells". Oncology Letters 7.6 (2014): 2149-2153.
Chicago
Ye, L., Sanders, A. J., Sun, P., Mason, M. D., Jiang, W. G."Capillary morphogenesis gene 2 regulates adhesion and invasiveness of prostate cancer cells". Oncology Letters 7, no. 6 (2014): 2149-2153. https://doi.org/10.3892/ol.2014.2038
Copy and paste a formatted citation
x
Spandidos Publications style
Ye L, Sanders AJ, Sun PH, Mason MD and Jiang WG: Capillary morphogenesis gene 2 regulates adhesion and invasiveness of prostate cancer cells. Oncol Lett 7: 2149-2153, 2014.
APA
Ye, L., Sanders, A.J., Sun, P., Mason, M.D., & Jiang, W.G. (2014). Capillary morphogenesis gene 2 regulates adhesion and invasiveness of prostate cancer cells. Oncology Letters, 7, 2149-2153. https://doi.org/10.3892/ol.2014.2038
MLA
Ye, L., Sanders, A. J., Sun, P., Mason, M. D., Jiang, W. G."Capillary morphogenesis gene 2 regulates adhesion and invasiveness of prostate cancer cells". Oncology Letters 7.6 (2014): 2149-2153.
Chicago
Ye, L., Sanders, A. J., Sun, P., Mason, M. D., Jiang, W. G."Capillary morphogenesis gene 2 regulates adhesion and invasiveness of prostate cancer cells". Oncology Letters 7, no. 6 (2014): 2149-2153. https://doi.org/10.3892/ol.2014.2038
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