Chronic lymphocytic leukemia presenting with ascites diagnosed by clonality analysis via gene rearrangement assay: A case report

Huang,Yen‑Min; Shih,Lee‑Yung; Dunn,Po; Wang,Po‑Nan; Kuo,Ming‑Chung; Wu,Jin‑Hou; Lin,Tung‑Liang; Tang,Tzung‑Chih; Chang,Hung; Kao,Hsiao‑Wen; Shih,Hsuan‑Jen; Hung,Yu‑Shin

doi:10.3892/ol.2014.2044

June-2014 Volume 7 Issue 6

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June-2014 Volume 7 Issue 6

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Case Report

Chronic lymphocytic leukemia presenting with ascites diagnosed by clonality analysis via gene rearrangement assay: A case report

Authors:
- Yen‑Min Huang
- Lee‑Yung Shih
- Po Dunn
- Po‑Nan Wang
- Ming‑Chung Kuo
- Jin‑Hou Wu
- Tung‑Liang Lin
- Tzung‑Chih Tang
- Hung Chang
- Hsiao‑Wen Kao
- Hsuan‑Jen Shih
- Yu‑Shin Hung
View Affiliations / Copyright

Affiliations: Department of Internal Medicine, Division of Hematology and Oncology, Chang Gung Memorial Hospital, Keelung, Taiwan, R.O.C., Department of Internal Medicine, Division of Hematology and Oncology, Chang Gung Memorial Hospital, Linkou, Taoyun 33305, Taiwan, R.O.C.
Pages: 1911-1914
|
Published online on: April 8, 2014

https://doi.org/10.3892/ol.2014.2044
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Abstract

The diagnosis of chronic lymphocytic leukemia (CLL) presenting with ascites is predominantly based on the morphological and immunophenotypic characteristics, which are comparable to peripheral blood and bone marrow cells. However, it is relatively difficult to diagnose CLL due to the pleomorphism of the lymphocytes in ascites. The current study presents an 80‑year‑old male with a prior diagnosis of CLL who developed large ascites. Predominant T lymphocytes rendered morphological and immunophenotypic diagnosis difficult. Clonality analysis of immunoglobulin (Ig) gene rearrangements was performed on the lymphocytes from the ascites to diagnose the involvement of CLL, a laparotomy and biopsy from the peritoneal node confirmed the involvement of small lymphocytic lymphoma/CLL. The clonality analysis of Ig gene rearrangements may provide a powerful and accurate method for diagnosing CLL presenting with ascites.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Chronic lymphocytic leukemia presenting with ascites diagnosed by clonality analysis via gene rearrangement assay: A case report

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Abstract

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