Tongue squamous cell carcinoma as a possible distinct entity in patients under 40 years old

Fang,Qi‑Gen; Shi,Shuang; Liu,Fa‑Yu; Sun,Chang‑Fu

doi:10.3892/ol.2014.2054

June-2014 Volume 7 Issue 6

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June-2014 Volume 7 Issue 6

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Article

Tongue squamous cell carcinoma as a possible distinct entity in patients under 40 years old

Authors:
- Qi‑Gen Fang
- Shuang Shi
- Fa‑Yu Liu
- Chang‑Fu Sun
View Affiliations / Copyright

Affiliations: Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, P.R. China, Department of Pediatric Dentistry, School of Stomatology, China Medical University, Shenyang, Liaoning 110002, P.R. China
Pages: 2099-2102
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Published online on: April 9, 2014

https://doi.org/10.3892/ol.2014.2054
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Abstract

Much controversy exists in the published literature regarding the clinical course and prognosis of tongue squamous cell carcinoma (SCC) in young patients. The aim of the current study was to evaluate the clinical results of tongue SCC in young patients. A total of 176 patients were included in this retrospective study. The patients were divided into two groups (young and old) according to an age cut‑off of 40 years. The χ2 test and Kaplan‑Meier method were used to analyze the variables. In total, 15 patients were <40 years old and placed into the young group, with five‑year recurrence‑free survival (RFS) and disease‑specific survival (DSS) rates of 30 and 63%, respectively, compared with 47 and 62%, respectively, in the old group. No significant differences were identified between the RFS and DSS rates of the two groups, however, the young patients exhibited a different failure pattern. Overall, nine out of 10 recurrences in the young group occurred at a primary site compared with 18 out of 70 in the old group (P<0.001). Univariate analysis revealed that gender and differentiation were associated with recurrence and neck nodal involvement. In addition, poor differentiation was found to significantly decrease the DSS time. However, the prognosis of tongue SCC in the young patient group did not appear to differ from that of the old patient group. Furthermore, in the young patient group, local recurrence was the most common failure pattern and tumor differentiation was the most important prognostic factor.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Tongue squamous cell carcinoma as a possible distinct entity in patients under 40 years old

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