Latent infection of human cytomegalovirus is associated with the development of gastric cancer

Jin,Jinji; Hu,Changyuan; Wang,Pengfei; Chen,Jing; Wu,Tiantian; Chen,Wenjing; Ye,Lulu; Zhu,Guangbao; Zhang,Lifang; Xue,Xiangyang; Shen,Xian

doi:10.3892/ol.2014.2148

Latent infection of human cytomegalovirus is associated with the development of gastric cancer

Authors:
- Jinji Jin
- Changyuan Hu
- Pengfei Wang
- Jing Chen
- Tiantian Wu
- Wenjing Chen
- Lulu Ye
- Guangbao Zhu
- Lifang Zhang
- Xiangyang Xue
- Xian Shen
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Affiliations: Department of General Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of General Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Department of Microbiology and Immunology, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China
Published online on: May 16, 2014 https://doi.org/10.3892/ol.2014.2148
Pages: 898-904

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Abstract

The worldwide contagion, human cytomegalovirus (HCMV), may cause a series of disorders in infected individuals. The aim of the present study was to investigate whether HCMV infection is associated with the development of gastric cancer. In this study, the positive expression of unique long (UL)133‑UL138 and immediate‑early (IE)1 genes, which are associated with viral latency and replication, respectively, were detected using nested polymerase chain reaction. A χ2 test and logistic regression analysis were performed to further investigate the preliminary data. The data indicated that the positive rate of UL133, UL135 and UL136 expression in cancer tissues was higher than that in paired normal tissues (P=0.01, 0.027 and 0.013, respectively). However, no significant differences were identified in the UL133‑138 locus and IE1 gene when associated with clinicopathological features. Furthermore, seven infection patterns were identified, with the UL133 + UL138 infection pattern representing the largest proportion in the cancer (60.34%) and normal tissues (42.11%). In conclusion, it is possible that the UL133‑UL138 locus is important in the occurrence of gastric cancer. The mechanism by which UL133‑UL138 locus expression differs in human gastric cancer requires further investigation.

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