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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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August-2014 Volume 8 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

BRAF‑activated long non‑coding RNA contributes to colorectal cancer migration by inducing epithelial‑mesenchymal transition

  • Authors:
    • Qinhao Guo
    • Yan Zhao
    • Jiejing Chen
    • Jun Hu
    • Shuwei Wang
    • Dongsheng Zhang
    • Yueming Sun
  • View Affiliations / Copyright

    Affiliations: Department of Colorectal Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 869-875
    |
    Published online on: May 19, 2014
       https://doi.org/10.3892/ol.2014.2154
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Abstract

Long non‑coding RNAs (lncRNAs) are recently identified regulators in tumorigenesis and tumour progression. BRAF‑activated lncRNA (BANCR) is overexpressed in melanoma and has a potential functional role in melanoma cell migration. However, little is known concerning the role of BANCR in the development of colorectal cancer (CRC). The current study examined BANCR expression in 60 pairs of CRC and matched adjacent normal tissues. The quantitative polymerase chain reaction results showed that BANCR was frequently overexpressed in cancer tissues and this overexpression was found to significantly correlate with lymph node metastasis and tumour stage. The ectopic expression of BANCR contributed to the migration of human CRC Caco‑2 cells, whereas knockdown of BANCR inhibited the migration of the HCT116 cells in vitro. Further investigation into the underlying mechanisms responsible for the migratory effects revealed that BANCR induced the epithelial‑mesenchymal transition (EMT) through an MEK/extracellular signal‑regulated kinase‑dependent mechanism as treatment with the MEK inhibitor, U0126 decreased migration and reversed the EMT in the BANCR‑overexpressed HCT116 cells. These results revealed the significance of BANCR in the molecular etiology of CRC and implied the potential application of BANCR in the therapeutic treatment of CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Guo Q, Zhao Y, Chen J, Hu J, Wang S, Zhang D and Sun Y: BRAF‑activated long non‑coding RNA contributes to colorectal cancer migration by inducing epithelial‑mesenchymal transition. Oncol Lett 8: 869-875, 2014.
APA
Guo, Q., Zhao, Y., Chen, J., Hu, J., Wang, S., Zhang, D., & Sun, Y. (2014). BRAF‑activated long non‑coding RNA contributes to colorectal cancer migration by inducing epithelial‑mesenchymal transition. Oncology Letters, 8, 869-875. https://doi.org/10.3892/ol.2014.2154
MLA
Guo, Q., Zhao, Y., Chen, J., Hu, J., Wang, S., Zhang, D., Sun, Y."BRAF‑activated long non‑coding RNA contributes to colorectal cancer migration by inducing epithelial‑mesenchymal transition". Oncology Letters 8.2 (2014): 869-875.
Chicago
Guo, Q., Zhao, Y., Chen, J., Hu, J., Wang, S., Zhang, D., Sun, Y."BRAF‑activated long non‑coding RNA contributes to colorectal cancer migration by inducing epithelial‑mesenchymal transition". Oncology Letters 8, no. 2 (2014): 869-875. https://doi.org/10.3892/ol.2014.2154
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Q, Zhao Y, Chen J, Hu J, Wang S, Zhang D and Sun Y: BRAF‑activated long non‑coding RNA contributes to colorectal cancer migration by inducing epithelial‑mesenchymal transition. Oncol Lett 8: 869-875, 2014.
APA
Guo, Q., Zhao, Y., Chen, J., Hu, J., Wang, S., Zhang, D., & Sun, Y. (2014). BRAF‑activated long non‑coding RNA contributes to colorectal cancer migration by inducing epithelial‑mesenchymal transition. Oncology Letters, 8, 869-875. https://doi.org/10.3892/ol.2014.2154
MLA
Guo, Q., Zhao, Y., Chen, J., Hu, J., Wang, S., Zhang, D., Sun, Y."BRAF‑activated long non‑coding RNA contributes to colorectal cancer migration by inducing epithelial‑mesenchymal transition". Oncology Letters 8.2 (2014): 869-875.
Chicago
Guo, Q., Zhao, Y., Chen, J., Hu, J., Wang, S., Zhang, D., Sun, Y."BRAF‑activated long non‑coding RNA contributes to colorectal cancer migration by inducing epithelial‑mesenchymal transition". Oncology Letters 8, no. 2 (2014): 869-875. https://doi.org/10.3892/ol.2014.2154
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