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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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August-2014 Volume 8 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

miR‑339‑5p inhibits cell migration and invasion in vitro and may be associated with the tumor‑node‑metastasis staging and lymph node metastasis of non‑small cell lung cancer

  • Authors:
    • Yun Li
    • Weiguo Zhao
    • Pengtao Bao
    • Chunsun Li
    • Xiu Qing Ma
    • Yanqing Li
    • Liang An Chen
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Chinese PLA General Hospital and Chinese PLA Medical School, Beijing 100853, P.R. China, Department of Respiratory Medicine, The 309th Hospital of Chinese People's Liberation Army, Beijing 100091, P.R. China
  • Pages: 719-725
    |
    Published online on: May 22, 2014
       https://doi.org/10.3892/ol.2014.2165
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Abstract

The aim of the present study was to investigate the potential role of microRNA (miRNA or miR) in invasion and metastasis of non‑small cell lung cancer (NSCLC). miRNA‑microarray analysis was used to detect the differentially expressed miRNAs between various metastatic levels of NSCLC cells. The microarray results were verified by quantitative polymerase chain reaction. The most clearly altered miRNA, miR‑339‑5p, was transfected into NSCLC cells and cell migration and invasion were investigated. The expression of miR‑339‑5p was 3.4662‑fold higher in the lower metastatic NSCLC cells. miR‑339‑5p significantly decreased tumor‑cell migration and the invasion capacity in vitro. In conclusion, miR‑339‑5p is important in NSCLC invasion and metastasis, indicating that miR‑339‑5p could be further evaluated as a biomarker for predicting the survival time of patients with NSCLC.
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1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012.

2 

Lee Y, Ahn C, Han J, et al: The nuclear RNase III Drosha initiates microRNA processing. Nature. 425:415–419. 2003.

3 

Lund E, Güttinger S, Calado A, et al: Nuclear export of microRNA precursors. Science. 303:95–98. 2004.

4 

Lee Y, Jeon K, Lee JT, et al: MicroRNA maturation: stepwise processing and subcellular localization. EMBO J. 21:4663–4670. 2002.

5 

Rana TM: Illuminating the silence: understanding the structure and function of small RNAs. Nat Rev Mol Cell Biol. 8:23–36. 2007.

6 

Yanaihara N, Caplen N, Bowman E, et al: Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell. 9:189–198. 2006.

7 

Gibbons DL, Lin W, Creighton CJ, et al: Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. Genes Dev. 23:2140–2151. 2009.

8 

Ceppi P, Mudduluru G, Kumarswamy R, et al: Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer. Mol Cancer Res. 8:1207–1216. 2010.

9 

Sobin LH, Gospodarowicz MK and Wittekind CH; International Union Against Cancer. TNM Classification of Malignant Tumours. 7th edition. WileyBlackwell; New York, NY: 2010

10 

Wu ZS, Wu Q, Wang CQ, et al: MiR-339-5p inhibits breast cancer cell migration and invasion in vitro and may be a potential biomarker for breast cancer prognosis. BMC Cancer. 10:5422010.

11 

Ma L, Teruya-Feldstein J and Weinberg RA: Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 449:682–688. 2007.

12 

Frankel LB, Christoffersen NR, Jacobsen A, et al: Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem. 283:1026–1033. 2008.

13 

Edmonds MD, Hurst DR, Vaidya KS, et al: Breast cancer metastasis suppressor 1 coordinately regulates metastasis-associated microRNA expression. Int J Cancer. 125:1778–1785. 2009.

14 

Dews M, Homayouni A, Yu D, et al: Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet. 38:1060–1065. 2006.

15 

Foekens JA, Sieuwerts AM, Smid M, et al: Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer. Proc Natl Acad Sci USA. 105:13021–13026. 2008.

16 

Song G, Zhang Y and Wang L: MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation. J Biol Chem. 284:31921–31927. 2009.

17 

Yu F, Yao H, Zhu P, et al: let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell. 131:1109–1123. 2007.

18 

Xiao F, Zuo Z, Cai G, et al: miRecords: an integrated resource for microRNA-target interactions. Nucleic Acids Res. 37(Database issue): D105–D110. 2009.

19 

Krek A, Grün D, Poy MN, et al: Combinatorial microRNA target predictions. Nat Genet. 37:495–500. 2005.

20 

John B, Enright AJ, Aravin A, et al: Human microRNA targets. PLoS Biol. 2:e3632004.

21 

Lewis BP, Shih IH, Jones-Rhoades MW, et al: Prediction of mammalian microRNA targets. Cell. 115:787–798. 2003.

22 

Phan RT, Saito M, Basso K, et al: BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells. Nat Immunol. 6:1054–1060. 2005.

23 

Polo JM, Dell’Oso T, Ranuncolo SM, et al: Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nat Med. 10:1329–1335. 2004.

24 

Pinto AE, André S, Silva G, et al: BCL-6 oncoprotein in breast cancer: loss of expression in disease progression. Pathobiology. 76:235–242. 2009.

25 

Yamamoto S, Tomita Y, Hoshida Y, et al: Expression level of valosin-containing protein (p97) is correlated with progression and prognosis of non-small-cell lung carcinoma. Ann Surg Oncol. 11:697–704. 2004.

26 

Yi P, Higa A, Taouji S, et al: Sorafenib-mediated targeting of the AAA+ ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death. Mol Cancer Ther. 11:2610–2620. 2012.

27 

Yamamoto S, Tomita Y, Hoshida Y, et al: Expression level of valosin-containing protein is strongly associated with progression and prognosis of gastriccarcinoma. J Clin Oncol. 21:2537–2544

28 

Yamamoto S, Tomita Y, Hoshida Y, et al: Expression of valosin-containing protein in colorectal carcinomas as a predictor for disease recurrence and prognosis. Clin Cancer Res. 10:651–657. 2004.

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Zhao W, Bao P, Li C, Ma XQ, Li Y and Chen LA: miR‑339‑5p inhibits cell migration and invasion in vitro and may be associated with the tumor‑node‑metastasis staging and lymph node metastasis of non‑small cell lung cancer. Oncol Lett 8: 719-725, 2014.
APA
Li, Y., Zhao, W., Bao, P., Li, C., Ma, X.Q., Li, Y., & Chen, L.A. (2014). miR‑339‑5p inhibits cell migration and invasion in vitro and may be associated with the tumor‑node‑metastasis staging and lymph node metastasis of non‑small cell lung cancer. Oncology Letters, 8, 719-725. https://doi.org/10.3892/ol.2014.2165
MLA
Li, Y., Zhao, W., Bao, P., Li, C., Ma, X. Q., Li, Y., Chen, L. A."miR‑339‑5p inhibits cell migration and invasion in vitro and may be associated with the tumor‑node‑metastasis staging and lymph node metastasis of non‑small cell lung cancer". Oncology Letters 8.2 (2014): 719-725.
Chicago
Li, Y., Zhao, W., Bao, P., Li, C., Ma, X. Q., Li, Y., Chen, L. A."miR‑339‑5p inhibits cell migration and invasion in vitro and may be associated with the tumor‑node‑metastasis staging and lymph node metastasis of non‑small cell lung cancer". Oncology Letters 8, no. 2 (2014): 719-725. https://doi.org/10.3892/ol.2014.2165
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Zhao W, Bao P, Li C, Ma XQ, Li Y and Chen LA: miR‑339‑5p inhibits cell migration and invasion in vitro and may be associated with the tumor‑node‑metastasis staging and lymph node metastasis of non‑small cell lung cancer. Oncol Lett 8: 719-725, 2014.
APA
Li, Y., Zhao, W., Bao, P., Li, C., Ma, X.Q., Li, Y., & Chen, L.A. (2014). miR‑339‑5p inhibits cell migration and invasion in vitro and may be associated with the tumor‑node‑metastasis staging and lymph node metastasis of non‑small cell lung cancer. Oncology Letters, 8, 719-725. https://doi.org/10.3892/ol.2014.2165
MLA
Li, Y., Zhao, W., Bao, P., Li, C., Ma, X. Q., Li, Y., Chen, L. A."miR‑339‑5p inhibits cell migration and invasion in vitro and may be associated with the tumor‑node‑metastasis staging and lymph node metastasis of non‑small cell lung cancer". Oncology Letters 8.2 (2014): 719-725.
Chicago
Li, Y., Zhao, W., Bao, P., Li, C., Ma, X. Q., Li, Y., Chen, L. A."miR‑339‑5p inhibits cell migration and invasion in vitro and may be associated with the tumor‑node‑metastasis staging and lymph node metastasis of non‑small cell lung cancer". Oncology Letters 8, no. 2 (2014): 719-725. https://doi.org/10.3892/ol.2014.2165
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