Cutaneous metastatic adenocarcinoma complicated by spontaneous tumor lysis syndrome: A case report

Wang,Yu; Yuan,Caijun; Liu,Xiaomei

doi:10.3892/ol.2014.2171

Cutaneous metastatic adenocarcinoma complicated by spontaneous tumor lysis syndrome: A case report

Authors:
- Yu Wang
- Caijun Yuan
- Xiaomei Liu
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Affiliations: Department of Oncology, Graduate School of Liaoning Medical University, Jinzhou, Liaoning 121000, P.R. China, Department of Oncology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121000, P.R. China
Published online on: May 23, 2014 https://doi.org/10.3892/ol.2014.2171
Pages: 905-907

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Abstract

The present study reports the case of a 71‑year‑old female with metastatic adenocarcinoma of the skin who developed tumor lysis syndrome (TLS) upon admittance to the First Affiliated Hospital of Liaoning Medical University (Jinzhou, China). The patient presented to the hospital due to multiple subcutaneous nodules, lethargy and weakness, but succumbed without any cancer therapy. Metastases to the skin from solid carcinomas are uncommon, and several studies have reported patients with minimal primary symptoms despite extensive metastatic skin disease. However, few cases were accompanied with spontaneous TLS at the time of presentation. TLS may be a severe complication during the therapy for hematological and oncological diseases. Although spontaneous TLS in internal tumors has been reported, it is extremely rare. The present study highlights the fact that multiple subcutaneous metastases may occur with the symptoms of spontaneous TLS, and may be key for the early recognition of this syndrome.

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