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Article

Clinicopathological and immunohistochemical analysis of spindle cell carcinoma of the larynx or hypopharynx: A report of three cases

  • Authors:
    • Yi Zheng
    • Mang Xiao
    • Jianguo Tang
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital Medical College of Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China
  • Pages: 748-752
    |
    Published online on: May 23, 2014
       https://doi.org/10.3892/ol.2014.2172
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Abstract

Spindle cell carcinoma (SpCC) is a rare and unusual biphasic malignant tumor, which involves sarcomatoid proliferation of pleomorphic spindle cells and squamous cell carcinoma. There are various reports on the clinical and pathological findings of SpCC in the head and neck; however, this type of tumor remains uncommon in the larynx and hypopharynx. The histogenesis of SpCC has been the subject of debate for many decades. Although it is generally accepted that SpCC is a monoclonal epithelial neoplasm, and the spindle cell element is derived from squamous epithelium with divergent mesenchymal differentiation, this type of tumor poses a significant diagnostic challenge to pathologists and clinicians with regard to the therapeutic approach. In the present report, three cases of SpCC of the larynx or hypopharynx were investigated. The histological and immunohistochemistry findings are presented to provide further data on this rare type of tumor.
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1 

Su HH, Chu ST, Hou YY, et al: Spindle cell carcinoma of the oral cavity and oropharynx: factors affecting outcome. J Chin Med Assoc. 69:478–483. 2006.

2 

Thompson LD, Wieneke JA, Miettinen M and Heffner DK: Spindle cell (sarcomatoid) carcinomas of the larynx: a clinicopathologic study of 187 cases. Am J Surg Pathol. 26:153–170. 2002.

3 

Batsakis JG: Tumors of the Head and Neck, Clinical and Pathological Considerations. 2nd edition. Williams & Wilkins; Baltimore, MA: pp. 217–219. 1979

4 

Viswanathan S, Rahman K, Pallavi S, et al: Sarcomatoid (spindle cell) carcinoma of the head and neck mucosal region: a clinicopathologic review of 103 cases from a tertiary referral cancer centre. Head Neck Pathol. 4:265–275. 2010.

5 

Batsakis JG and Suarez P: Sarcomatoid carcinoma of the aerodigestive tracts. Adv Anat Pathol. 7:282–293. 2000.

6 

Batsakis JG, Rice DH and Howard DR: The pathology of head and neck tumors: spindle cell lesions (sarcomatoid carcinomas, nodular fasciitis, and fibrosarcoma) of the aerodigestive tracts, Part 14. Head Neck Surg. 4:499–513. 1982.

7 

Takata T, Ito H, Ogawa I, et al: Spindle cell squamous carcinoma of the oral region. An immunohistochemical and ultrastructural study on the histogenesis and differential diagnosis with a clinicopathological analysis of six cases. Virchows Arch A Pathol Anat Histopathol. 419:177–182. 1991.

8 

Leventon GS and Evans HL: Sarcomatoid squamous cell carcinoma of the mucous membranes of the head and neck: a clinicpathologic study of 20 cases. Cancer. 48:994–1003. 1981.

9 

Guarino M, Tricomi P, Giordano F and Christofori E: Sarcomatoid carcinomas: pathological and histopathogenetic considerations. Pathology. 28:298–305. 1996.

10 

Thompson L, Chang B and Barsky SH: Monoclonal origins of malignant mixed tumors (carcinosarcomas). Evidence for a divergent histogenesis. Am J Surg Pathol. 20:277–285. 1996.

11 

Torenbeek R, Hermsen MA, Meijer GA, et al: Analysis by comparative genomic hybridization of epithelial and spindle cell components in sarcomatoid carcinoma and carcinosarcoma: histogenetic aspects. J Pathol. 189:338–343. 1999.

12 

Anderson CE and Al-Nafussi A: Spindle cell lesions of the head and neck: an overview and diagnostic approach. Diagn Histopathol. 15:264–272. 2009.

13 

Kudo Y, Ogawa I, Kitagawa M, et al: Establishment and characterization of a spindle cell squamous carcinoma cell line. J Oral Pathol Med. 35:479–483. 2006.

14 

Batsakis JG: ‘Pseudosarcoma’ of the mucous membranes in the head and neck. J Laryngol Otol. 95:311–316. 1981.

15 

Munakata R, Cheng J, Nakajima T and Saku T: Spindle cell carcinoma of the gingiva: report of an autopsy case. J Oral Pathol Med. 27:180–184. 1998.

16 

Lane N: Pseudosarcoma (polypoid sarcoma-like masses) associated with squamous-cell carcinoma of the mouth, fauces, and larynx. Cancer. 10:19–41. 1957.

17 

Battifora H: Spindle cell carcinoma. Cancer. 37:2275–2282. 1976.

18 

Viswanathan S, Rahman K, Pallavi S, et al: Sarcomatoid (spindle cell) carcinoma of the head and neck mucosal region: a clinicopathologic review of 103 cases from a tertiary referral cancer centre. Head Neck Pathol. 4:265–275. 2010.

19 

Ansari-Lari MA, Hoque MO, Califano J and Westra WH: Immunohistochemical p53 expression patterns in sarcomatoid carcinoma of the upper respiratory tract. Am J Surg Pathol. 26:1024–1031. 2002.

20 

Shibuya Y, Umeda M, Yokoo S and Komori T: Spindle cell squamous carcinoma of the maxilla: report of a case with immunohistochemical analysis. J Oral Maxillofac Surg. 58:1164–1169. 2000.

21 

Toda S, Yonemitsu N, Miyabara S, et al: Polypoid squamous cell carcinoma of the larynx. An immunohistochemical study for ras p21 and cytokeratin. Pathol Res Pract. 185:860–866. 1989.

22 

Sarma A, Das R, Sharma JD and Kataki AC: Spindle cell carcinoma of the head and neck: A clinicopathological and immunohistochemical study of 40 Cases. J Cancer Ther. 3:1055–1059. 2012.

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Copy and paste a formatted citation
Spandidos Publications style
Zheng Y, Xiao M and Tang J: Clinicopathological and immunohistochemical analysis of spindle cell carcinoma of the larynx or hypopharynx: A report of three cases. Oncol Lett 8: 748-752, 2014.
APA
Zheng, Y., Xiao, M., & Tang, J. (2014). Clinicopathological and immunohistochemical analysis of spindle cell carcinoma of the larynx or hypopharynx: A report of three cases. Oncology Letters, 8, 748-752. https://doi.org/10.3892/ol.2014.2172
MLA
Zheng, Y., Xiao, M., Tang, J."Clinicopathological and immunohistochemical analysis of spindle cell carcinoma of the larynx or hypopharynx: A report of three cases". Oncology Letters 8.2 (2014): 748-752.
Chicago
Zheng, Y., Xiao, M., Tang, J."Clinicopathological and immunohistochemical analysis of spindle cell carcinoma of the larynx or hypopharynx: A report of three cases". Oncology Letters 8, no. 2 (2014): 748-752. https://doi.org/10.3892/ol.2014.2172
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng Y, Xiao M and Tang J: Clinicopathological and immunohistochemical analysis of spindle cell carcinoma of the larynx or hypopharynx: A report of three cases. Oncol Lett 8: 748-752, 2014.
APA
Zheng, Y., Xiao, M., & Tang, J. (2014). Clinicopathological and immunohistochemical analysis of spindle cell carcinoma of the larynx or hypopharynx: A report of three cases. Oncology Letters, 8, 748-752. https://doi.org/10.3892/ol.2014.2172
MLA
Zheng, Y., Xiao, M., Tang, J."Clinicopathological and immunohistochemical analysis of spindle cell carcinoma of the larynx or hypopharynx: A report of three cases". Oncology Letters 8.2 (2014): 748-752.
Chicago
Zheng, Y., Xiao, M., Tang, J."Clinicopathological and immunohistochemical analysis of spindle cell carcinoma of the larynx or hypopharynx: A report of three cases". Oncology Letters 8, no. 2 (2014): 748-752. https://doi.org/10.3892/ol.2014.2172
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