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Article

Impact of histone deacetylase 1 and metastasis‑associated gene 1 expression in esophageal carcinogenesis

  • Authors:
    • Tomoharu Miyashita
    • Hidehiro Tajima
    • Masayoshi Munemoto
    • Furhawn  A. Shah
    • John  W. Harmon
    • Toshifumi Watanabe
    • Masatoshi Shoji
    • Koichi Okamoto
    • Shinichi Nakanuma
    • Seisho Sakai
    • Jun Kinoshita
    • Isamu Makino
    • Keishi  Nakamura
    • Hironori Hayashi
    • Katsunobu Oyama
    • Masafumi Inokuchi
    • Hisatoshi  Nakagawara
    • Hiroyuki Takamura
    • Itasu Ninomiya
    • Hirohisa Kitagawa
    • Sachio Fushida
    • Kenichi Mukaisho
    • Takashi Fujimura
    • Tetsuo Ohta
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Kanazawa University Hospital, Kanazawa, Ishikawa 920‑8641, Japan, Department of Surgery, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA, Department of Pathology, Shiga University of Medical Science, Otsu, Shiga 520‑2192, Japan
  • Pages: 758-764
    |
    Published online on: May 26, 2014
       https://doi.org/10.3892/ol.2014.2176
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Abstract

Animal models are important for the development of novel therapies for esophageal cancer. Histone deacetylase 1 (HDAC1)/metastasis‑associated gene (MTA1) complexes inhibit p53 acetylation and thus, inhibit p53‑induced apoptosis. The aim of the present study was to evaluate HDAC1 and MTA1 expression in esophageal carcinogenesis in rats. The rats underwent a total gastrectomy followed by esophagojejunostomy to induce chronic duodenal content reflux esophagitis. The rats were sacrificed sequentially at 20, 30, 40 and 50 weeks post‑surgery and the esophagi were examined. Immunohistochemical analysis was conducted to assess the expression and localization of HDAC1 and MTA1. At 20 weeks post‑surgery, squamous proliferative hyperplasia and Barrett's metaplasia (BM) were observed. While, adenocarcinoma‑associated BM and squamous cell carcinoma were observed at 30‑50 weeks post‑surgery. The nuclear expression of HDAC1 and MTA1 was observed in all of the stages of squamous carcinogenesis and adenocarcinogenesis, although not in the normal esophageal epithelium. The expression of HDAC1 and MTA1 may be involved in duodenoesophageal reflux‑induced neoplastic transformation of the esophageal mucosa into cancer cells with squamous and adeno differentiation.
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Copy and paste a formatted citation
Spandidos Publications style
Miyashita T, Tajima H, Munemoto M, Shah FA, Harmon JW, Watanabe T, Shoji M, Okamoto K, Nakanuma S, Sakai S, Sakai S, et al: Impact of histone deacetylase 1 and metastasis‑associated gene 1 expression in esophageal carcinogenesis. Oncol Lett 8: 758-764, 2014.
APA
Miyashita, T., Tajima, H., Munemoto, M., Shah, F.A., Harmon, J.W., Watanabe, T. ... Ohta, T. (2014). Impact of histone deacetylase 1 and metastasis‑associated gene 1 expression in esophageal carcinogenesis. Oncology Letters, 8, 758-764. https://doi.org/10.3892/ol.2014.2176
MLA
Miyashita, T., Tajima, H., Munemoto, M., Shah, F. A., Harmon, J. W., Watanabe, T., Shoji, M., Okamoto, K., Nakanuma, S., Sakai, S., Kinoshita, J., Makino, I., Nakamura, K., Hayashi, H., Oyama, K., Inokuchi, M., Nakagawara, H., Takamura, H., Ninomiya, I., Kitagawa, H., Fushida, S., Mukaisho, K., Fujimura, T., Ohta, T."Impact of histone deacetylase 1 and metastasis‑associated gene 1 expression in esophageal carcinogenesis". Oncology Letters 8.2 (2014): 758-764.
Chicago
Miyashita, T., Tajima, H., Munemoto, M., Shah, F. A., Harmon, J. W., Watanabe, T., Shoji, M., Okamoto, K., Nakanuma, S., Sakai, S., Kinoshita, J., Makino, I., Nakamura, K., Hayashi, H., Oyama, K., Inokuchi, M., Nakagawara, H., Takamura, H., Ninomiya, I., Kitagawa, H., Fushida, S., Mukaisho, K., Fujimura, T., Ohta, T."Impact of histone deacetylase 1 and metastasis‑associated gene 1 expression in esophageal carcinogenesis". Oncology Letters 8, no. 2 (2014): 758-764. https://doi.org/10.3892/ol.2014.2176
Copy and paste a formatted citation
x
Spandidos Publications style
Miyashita T, Tajima H, Munemoto M, Shah FA, Harmon JW, Watanabe T, Shoji M, Okamoto K, Nakanuma S, Sakai S, Sakai S, et al: Impact of histone deacetylase 1 and metastasis‑associated gene 1 expression in esophageal carcinogenesis. Oncol Lett 8: 758-764, 2014.
APA
Miyashita, T., Tajima, H., Munemoto, M., Shah, F.A., Harmon, J.W., Watanabe, T. ... Ohta, T. (2014). Impact of histone deacetylase 1 and metastasis‑associated gene 1 expression in esophageal carcinogenesis. Oncology Letters, 8, 758-764. https://doi.org/10.3892/ol.2014.2176
MLA
Miyashita, T., Tajima, H., Munemoto, M., Shah, F. A., Harmon, J. W., Watanabe, T., Shoji, M., Okamoto, K., Nakanuma, S., Sakai, S., Kinoshita, J., Makino, I., Nakamura, K., Hayashi, H., Oyama, K., Inokuchi, M., Nakagawara, H., Takamura, H., Ninomiya, I., Kitagawa, H., Fushida, S., Mukaisho, K., Fujimura, T., Ohta, T."Impact of histone deacetylase 1 and metastasis‑associated gene 1 expression in esophageal carcinogenesis". Oncology Letters 8.2 (2014): 758-764.
Chicago
Miyashita, T., Tajima, H., Munemoto, M., Shah, F. A., Harmon, J. W., Watanabe, T., Shoji, M., Okamoto, K., Nakanuma, S., Sakai, S., Kinoshita, J., Makino, I., Nakamura, K., Hayashi, H., Oyama, K., Inokuchi, M., Nakagawara, H., Takamura, H., Ninomiya, I., Kitagawa, H., Fushida, S., Mukaisho, K., Fujimura, T., Ohta, T."Impact of histone deacetylase 1 and metastasis‑associated gene 1 expression in esophageal carcinogenesis". Oncology Letters 8, no. 2 (2014): 758-764. https://doi.org/10.3892/ol.2014.2176
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