Significant association between the Axin2 rs2240308 single nucleotide polymorphism and the incidence of prostate cancer

Ma,Chao; Liu,Chunxiao; Huang,Peng; Kaku,Haruki; Chen,Jie; Guo,Kai; Ueki,Hideo; Sakai,Akiko; Nasu,Yasutomo; Kumon,Hiromi; Shimizu,Kenji; Watanabe,Masami

doi:10.3892/ol.2014.2177

August-2014 Volume 8 Issue 2

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August-2014 Volume 8 Issue 2

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Article

Significant association between the Axin2 rs2240308 single nucleotide polymorphism and the incidence of prostate cancer

Authors:
- Chao Ma
- Chunxiao Liu
- Peng Huang
- Haruki Kaku
- Jie Chen
- Kai Guo
- Hideo Ueki
- Akiko Sakai
- Yasutomo Nasu
- Hiromi Kumon
- Kenji Shimizu
- Masami Watanabe
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Affiliations: Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, P.R. China, Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan, Department of Urology, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, Department of Molecular Genetics, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
Pages: 789-794
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Published online on: May 26, 2014

https://doi.org/10.3892/ol.2014.2177
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Abstract

The Wnt signaling pathway plays a crucial role in human cancer development, and axis inhibition protein 2 (Axin2) is a master scaffold protein involved in Wnt signaling. Axin2 negatively regulates Wnt signaling and acts as a tumor suppressor protein. The present study evaluated the association between the Axin2 single nucleotide polymorphism (SNP) rs2240308 [guanine (G)/adenine (A)] and the incidence of prostate cancer. In total, 103 patients with prostate cancer and 100 cancer‑free control males were included in this case‑control study, and were genotyped using the genomic DNA extracted from peripheral blood samples. The results revealed a higher incidence of prostate cancer in the subjects with the homozygous GG genotype and a reduced cancer incidence in the patients with the GA genotype of the rs2240308 SNP (G/A) in the Axin2 gene. The adjusted odds ratio for carriers with the GA genotype was 0.377 (95% CI, 0.206‑0.688; P=0.001) and that for the AA genotype was 0.830 (95% CI, 0.309‑2.232; P=0.712) compared with the GG genotype. Therefore, the GA genotype was found to exhibit a protective effect that decreased the risk of prostate cancer. To the best of our knowledge, this is the first study to demonstrate the significant association between this SNP (rs2240308, G/A) and the risk of prostate cancer. This association indicates the possibility that the variations in the Axin2 gene in this position may play a significant role in promoting the development of cancer in the prostate. We believe that the Axin2 SNP (rs2240308) could be a useful biomarker for the predisposition and early diagnosis of the disease.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Significant association between the Axin2 rs2240308 single nucleotide polymorphism and the incidence of prostate cancer

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