Cytological features of pure micropapillary carcinoma of various organs: A report of eight cases

Huq,Gülben Erdem; Canberk,Şule; Öznur,Meltem; Yıldız,Pelin; Bahadır,Burak; Behzatoğlu,Kemal

doi:10.3892/ol.2014.2198

August-2014 Volume 8 Issue 2

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August-2014 Volume 8 Issue 2

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Article

Cytological features of pure micropapillary carcinoma of various organs: A report of eight cases

Authors:
- Gülben Erdem Huq
- Şule Canberk
- Meltem Öznur
- Pelin Yıldız
- Burak Bahadır
- Kemal Behzatoğlu
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Affiliations: Department of Pathology, Istanbul Education and Research Hospital, Istanbul 34098, Turkey, Department of Pathology, Istanbul University, Cerrahpasa Medical Faculty Istanbul 34320, Turkey, Department of Pathology, Namık Kemal University Medical Faculty, Tekirdağ 59100, Turkey, Department of Pathology, Bezmialem University, Medical Faculty, Istanbul 34093, Turkey, Department of Pathology, Bülent Ecevit University, Zonguldak 67100, Turkey
Pages: 705-710
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Published online on: May 29, 2014

https://doi.org/10.3892/ol.2014.2198
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Abstract

Micropapillary carcinoma (MPC) is a rare aggressive tumor, which generally accompanies the primary carcinoma of the organ of its origin, while the pure form is extremely uncommon. Angiolymphatic involvement is widespread and a considerable proportion of the cases present with metastases. The current study presents eight pure MPC cases arising from the breast (n=3), urinary bladder (n=3), parotid gland (n=1) and lung (n=1, presenting with pericardial effusion), with the cytological findings. The eight patients included three female and five male cases aged between 48 and 74 years. The most common cytological findings were three‑dimensional aggregates, cell clusters with angulated or scalloped borders, single cells with a columnar configuration and eccentric nuclei, and high‑grade nuclear features. Histopathological sections showed accompanying in situ ductal carcinoma in the cases of MPC arising in the parotid gland and breast (n=3), and one case in the bladder exhibited only in situ MPC. The average follow‑up period was 20 months (range, 6‑54 months) and, during this period, three patients succumbed to the disease. At present, four patients are alive with disease and one patient is alive and disease‑free. In conclusion, cytology is an important tool for the diagnosis and management of MPC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Cytological features of pure micropapillary carcinoma of various organs: A report of eight cases

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