Natural killer/T‑cell lymphoma‑associated hemophagocytic syndrome: A case report
- Authors:
- Published online on: May 30, 2014 https://doi.org/10.3892/ol.2014.2202
- Pages: 886-890
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Abstract
Natural killer (NK)/T‑cell lymphoma‑associated hemophagocytic syndrome (HPS) is a rare and fatal disease with no optimal treatment. The present study reports the clinical features, diagnosis and treatment process of three patients with relapsed NK/T‑cell lymphoma‑associated HPS. All of the patients were classified as Ann Arbor stage IV and presented with a poor performance status. Two patients were successfully treated with a pegaspargase‑containing combination regimen and one patient succumbed due to serious complications. These cases indicate that for patients with a history of lymphoma, the diagnosis of HPS should be considered when patients present with progressive high fever, pancytopenia and liver dysfunction. Early identification and effective treatments, including pegaspargase‑based regimens are essential for an enhanced prognosis.
