Adenocarcinoma with adenoma in the jejunum suggesting an adenoma‑carcinoma sequence in the small bowel: A case report

Nakano,Yorika; Adachi,Yasushi; Okamoto,Hideki; Kiyama,Yoshiaki; Koyama,Takashi; Nakamura,Shin‑Ichi; Li,Qing; Sakaida,Noriko; Uemura,Yoshiko; Ikehara,Susumu

doi:10.3892/ol.2014.2210

August-2014 Volume 8 Issue 2

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August-2014 Volume 8 Issue 2

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Case Report

Adenocarcinoma with adenoma in the jejunum suggesting an adenoma‑carcinoma sequence in the small bowel: A case report

Authors:
- Yorika Nakano
- Yasushi Adachi
- Hideki Okamoto
- Yoshiaki Kiyama
- Takashi Koyama
- Shin‑Ichi Nakamura
- Qing Li
- Noriko Sakaida
- Yoshiko Uemura
- Susumu Ikehara
View Affiliations / Copyright

Affiliations: Department of Surgical Pathology, Kansai Medical University‑Hirakata Hospital, Osaka 573‑1191, Japan, Division of Surgical Pathology, Toyooka Hospital, Hyogo 668‑8501, Japan, Department of Surgery, Asago‑Yanase Medical Center, Hyogo 669‑5103, Japan, Department of Radiology, Toyooka Hospital, Hyogo 668‑8501, Japan, LSI Medience Corporation, Tokyo 174-0051, Japan, Department of Stem Cell Disorders, Kansai Medical University, Osaka 573‑1010, Japan
Pages: 633-636
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Published online on: June 2, 2014

https://doi.org/10.3892/ol.2014.2210
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Abstract

Other than that in the duodenum, adenocarcinoma in the small bowel is rare. The present study describes a case of adenocarcinoma with adenoma in the jejunum. A 70‑year‑old male was admitted to hospital due to dehydration induced by abdominal discomfort and difficulty with oral intake. Computed tomography revealed a tumor in the upper side of the jejunum, which was subsequently resected. The tumor contained adenocarcinoma and adenoma. The protein expression of p53 and Ki‑67 was analyzed in the normal mucosa, adenoma and adenocarcinoma. The number of epithelial cells expressing p53 and Ki‑67 was found to increase in the adenoma tissue compared with that in the normal mucosa. In the adenocarcinoma tissue, the number of cells expressing p53 and Ki‑67 further increased, suggesting that an adenoma‑adenocarcinoma sequence may occur in the small bowel, similar to that observed in the large bowel.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Adenocarcinoma with adenoma in the jejunum suggesting an adenoma‑carcinoma sequence in the small bowel: A case report

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