Adenocarcinoma with adenoma in the jejunum suggesting an adenoma‑carcinoma sequence in the small bowel: A case report
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- Published online on: June 2, 2014 https://doi.org/10.3892/ol.2014.2210
- Pages: 633-636
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Abstract
Other than that in the duodenum, adenocarcinoma in the small bowel is rare. The present study describes a case of adenocarcinoma with adenoma in the jejunum. A 70‑year‑old male was admitted to hospital due to dehydration induced by abdominal discomfort and difficulty with oral intake. Computed tomography revealed a tumor in the upper side of the jejunum, which was subsequently resected. The tumor contained adenocarcinoma and adenoma. The protein expression of p53 and Ki‑67 was analyzed in the normal mucosa, adenoma and adenocarcinoma. The number of epithelial cells expressing p53 and Ki‑67 was found to increase in the adenoma tissue compared with that in the normal mucosa. In the adenocarcinoma tissue, the number of cells expressing p53 and Ki‑67 further increased, suggesting that an adenoma‑adenocarcinoma sequence may occur in the small bowel, similar to that observed in the large bowel.
