Crucial role of treatment with palliative intent for a patient with advanced thymic carcinoma

Nagamata,Makoto; Okuma,Yusuke; Yamada,Yuko; Hosomi,Yukio; Hishima,Tsunekazu

doi:10.3892/ol.2014.2217

August-2014 Volume 8 Issue 2

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August-2014 Volume 8 Issue 2

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Crucial role of treatment with palliative intent for a patient with advanced thymic carcinoma

Authors:
- Makoto Nagamata
- Yusuke Okuma
- Yuko Yamada
- Yukio Hosomi
- Tsunekazu Hishima
View Affiliations / Copyright

Affiliations: Department of Thoracic Oncology and Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan, Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan
Pages: 513-516
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Published online on: June 3, 2014

https://doi.org/10.3892/ol.2014.2217
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Abstract

Thymic carcinoma is a rare cancer that is more aggressive and shows a poorer prognosis compared with thymoma. Molecular analysis has demonstrated that this entity is clearly distinct from thymoma. However, no definitive clinical management has been reported, and the roles of chemotherapy and radiotherapy for advanced thymic carcinoma remain unclear given the rarity of this clinicopathology. The current study reports the case of a 65‑year‑old male who presented with advanced thymic carcinoma with solitary brain and pulmonary metastases, but demonstrated long‑term survival following multiple lines of chemotherapy and radiotherapy with palliative intent. Although the solitary brain metastasis was well controlled for several years using whole‑brain irradiation, cognitive function gradually declined with cerebral atrophy. Thymic carcinoma is known to show a poor prognosis and aggressive clinical progress, however, it occasionally demonstrates a clinically indolent course. Modalities of treatment should thus be selected prudently to avoid toxicity, in consideration of the possibility of long‑term survival. Stereotactic radiation therapy for brain metastases, including cyberknife or γ‑knife surgery, appears to represent the optimal local treatment for such patients with unexpectedly longer survival due to indolent thymic carcinoma.

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1	Eng TY, Fuller CD, Jagirdar J, Bains Y and Thomas CR Jr: Thymic carcinoma: state of the art review. Int J Radiat Oncol Biol Phys. 59:654–664. 2004.
2	Shimosato Y, Kameya T, Nagai K and Suemasu K: Squamous cell carcinoma of the thymus. An analysis of eight cases. Am J Surg Pathol. 1:109–121. 1977.
3	Travis WD, Brambilla E, Müller-Hermelink HK and Harris CC: World health organization classification of tumors. Pathology and Genetics of Tumors of the Lung, Pleura, Thymus and Heart. Chapter 3. 3rd edition. IARC Press; Lyon: pp. 145–197. 2004
4	Okumura M, Ohta M, Tateyama H, et al: The world health organization histologic classification system reflects the oncologic behavior of thymoma: a clinical study of 273 patients. Cancer. 94:624–632. 2002.
5	Quintanilla-Martinez L, Wilkins EW Jr, Choi N, Efird J, Hug E and Harris NL: Thymoma. Histologic subclassification is an independent prognostic factor. Cancer. 74:606–617. 1994.
6	Müller-Hermelink HK, Marino M and Palestro G: Pathology of thymic epithelial tumors. Curr Top Pathol. 75:207–268. 1986.
7	Petrini I, Zucali PA, Lee HS, et al: Expression and mutational status of c-kit in thymic epithelial tumors. J Thorac Oncol. 5:1447–1453. 2010.
8	Mimae T, Tsuta K, Kondo T, et al: Protein expression and gene copy number changes of receptor tyrosine kinase in thymomas and thymic carcinomas. Ann Oncol. 23:3129–3137. 2012.
9	Fornasiero A, Daniele O, Ghiotto C, et al: Chemotherapy for invasive thymoma. A 13-year experience. Cancer. 68:30–33. 1991.
10	Loehrer PJ Sr, Kim K, Aisner SC, et al: Cisplatin plus doxorubicin plus cyclophosphamide in metastatic or recurrent thymoma: final results of an intergroup trial. The Eastern Cooperative Oncology Group, Southwest Oncology Group, and Southeastern Cancer Study Group. J Clin Oncol. 12:1164–1168. 1994.
11	Lemma GL, Lee JW, Aisner SC, et al: Phase II study of carboplatin and paclitaxel in advanced thymoma and thymic carcinoma. J Clin Oncol. 29:2060–2065. 2011.
12	National Comprehensive Cancer Network. Thymomas and thymic carcinomas (version 1. 2014). http://www.nccn.org/professionals/physician_gls/pdf/thymic.pdf. Accessed April 1, 2014
13	Girard N: Thymic epithelial tumours: From basic principles to individualised treatment strategies. Eur Respir Rev. 22:75–87. 2013.
14	Okuma Y, Hosomi Y, Takagi Y, et al: Clinical outcomes with chemotherapy for advanced thymic carcinoma. Lung Cancer. 80:75–80. 2013.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Crucial role of treatment with palliative intent for a patient with advanced thymic carcinoma

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