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Article

Utility of diffusion‑weighted imaging to assess hepatocellular carcinoma viability following transarterial chemoembolization

  • Authors:
    • Zheng Yuan
    • Wen‑Tao Li
    • Xiao‑Dan Ye
    • Wei‑Jun Peng
    • Xiang‑Sheng Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Shanghai People's Liberation Army No. 85 Hospital, Shanghai 200052, P.R. China, Department of Radiology, Fudan University, Shanghai Cancer Center, Shanghai 200032, P.R. China, Department of Radiology, Shanghai Chest Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200030, P.R. China, Department of Radiology, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, P.R. China
  • Pages: 831-836
    |
    Published online on: June 5, 2014
       https://doi.org/10.3892/ol.2014.2228
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Abstract

The purpose of the present study was to evaluate whether diffusion‑weighted imaging (DWI) can be used to assess hepatocellular carcinoma (HCC) viability following transarterial chemoembolization (TACE). A total of 41 consecutive patients were treated according to chemoembolization protocols. The follow‑up was performed between six and eight weeks post‑chemoembolization by multidetector computed tomography [or enhanced magnetic resonance imaging (MRI)] and DW‑MRI on the same day. The presence of any residual tumor and the extent of tumor necrosis were evaluated according to the European Association for the Study of the Liver. The apparent diffusion coefficient (ADC) values of the entire area of the treated mass and the vital and necrotic tumor tissues were recorded. Correlation coefficients were also calculated to compare the percentage of necrosis with ADC values. The mean ADC values of the necrotic and vital tumor tissues were 2.22±0.31x10‑3 mm2/sec and 1.42±0.25x10‑3 mm2/sec, respectively (Mann‑Whitney U test, P<0.001). The results from the receiver operating characteristic analysis showed that the threshold ADC value was 1.84x10‑3 mm2/sec with 92.3% sensitivity and 100% specificity for identifying the necrotic tumor tissues. A significant linear regression correlation was identified between the ADC value of the entire area of the treated mass and the extent of tumor necrosis (r=0.58; P<0.001). In conclusion, DWI can be used to assess HCC viability following TACE.
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Copy and paste a formatted citation
Spandidos Publications style
Yuan Z, Li WT, Ye XD, Peng WJ and Xiao XS: Utility of diffusion‑weighted imaging to assess hepatocellular carcinoma viability following transarterial chemoembolization. Oncol Lett 8: 831-836, 2014.
APA
Yuan, Z., Li, W., Ye, X., Peng, W., & Xiao, X. (2014). Utility of diffusion‑weighted imaging to assess hepatocellular carcinoma viability following transarterial chemoembolization. Oncology Letters, 8, 831-836. https://doi.org/10.3892/ol.2014.2228
MLA
Yuan, Z., Li, W., Ye, X., Peng, W., Xiao, X."Utility of diffusion‑weighted imaging to assess hepatocellular carcinoma viability following transarterial chemoembolization". Oncology Letters 8.2 (2014): 831-836.
Chicago
Yuan, Z., Li, W., Ye, X., Peng, W., Xiao, X."Utility of diffusion‑weighted imaging to assess hepatocellular carcinoma viability following transarterial chemoembolization". Oncology Letters 8, no. 2 (2014): 831-836. https://doi.org/10.3892/ol.2014.2228
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan Z, Li WT, Ye XD, Peng WJ and Xiao XS: Utility of diffusion‑weighted imaging to assess hepatocellular carcinoma viability following transarterial chemoembolization. Oncol Lett 8: 831-836, 2014.
APA
Yuan, Z., Li, W., Ye, X., Peng, W., & Xiao, X. (2014). Utility of diffusion‑weighted imaging to assess hepatocellular carcinoma viability following transarterial chemoembolization. Oncology Letters, 8, 831-836. https://doi.org/10.3892/ol.2014.2228
MLA
Yuan, Z., Li, W., Ye, X., Peng, W., Xiao, X."Utility of diffusion‑weighted imaging to assess hepatocellular carcinoma viability following transarterial chemoembolization". Oncology Letters 8.2 (2014): 831-836.
Chicago
Yuan, Z., Li, W., Ye, X., Peng, W., Xiao, X."Utility of diffusion‑weighted imaging to assess hepatocellular carcinoma viability following transarterial chemoembolization". Oncology Letters 8, no. 2 (2014): 831-836. https://doi.org/10.3892/ol.2014.2228
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