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Review

Progress of cancer research on astrocyte elevated gene‑1/Metadherin (Review)

  • Authors:
    • Yong Huang
    • Le‑Ping Li
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China
  • Pages: 493-501
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    Published online on: June 5, 2014
       https://doi.org/10.3892/ol.2014.2231
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Abstract

Tumor development is initiated by an accumulation of numerous genetic and epigenetic alterations that promote tumor initiation, invasion and metastasis. Astrocyte elevated gene‑1 [AEG‑1; also known as Metadherin (MTDH) and Lysine‑rich CEACAM1 co‑isolated (LYRIC)] has emerged in recent years as a potentially crucial mediator of tumor malignancy, and a key converging point of a complex network of oncogenic signaling pathways. AEG‑1/MTDH has a multifunctional role in tumor development that has been found to be involved in the following signaling cascades: i) The Ha‑Ras and PI3K/Akt pathways; ii) the nuclear factor‑κB signaling pathway; iii) the ERK/mitogen‑activated protein kinase and Wnt/β‑catenin pathways; and iv) the Aurora‑A kinase signaling pathway. Studies have established that AEG‑1/MTDH is crucial in tumor progression, including transformation, the evasion of apoptosis, invasion, angiogenesis and metastasis. In addition, recent clinical studies have convincingly associated AEG‑1/MTDH with tumor progression and poor prognosis in a number of cancer types, including hepatocellular, esophageal squamous cell, gallbladder and renal cell carcinomas, breast, non‑small cell lung, prostate, gastric and colorectal cancers, and glioma, melanoma, neuroblastoma and osteosarcoma. AEG‑1/MTDH may be used as a biomarker to identify subgroups of patients who require more intensive treatments and who are likely to benefit from AEG‑1/MTDH‑targeted therapies. The therapeutic targeting of AEG‑1/MTDH may simultaneously block metastasis, suppress tumor growth and enhance the efficacy of chemotherapeutic treatments.
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Copy and paste a formatted citation
Spandidos Publications style
Huang Y and Li LP: Progress of cancer research on astrocyte elevated gene‑1/Metadherin (Review). Oncol Lett 8: 493-501, 2014.
APA
Huang, Y., & Li, L. (2014). Progress of cancer research on astrocyte elevated gene‑1/Metadherin (Review). Oncology Letters, 8, 493-501. https://doi.org/10.3892/ol.2014.2231
MLA
Huang, Y., Li, L."Progress of cancer research on astrocyte elevated gene‑1/Metadherin (Review)". Oncology Letters 8.2 (2014): 493-501.
Chicago
Huang, Y., Li, L."Progress of cancer research on astrocyte elevated gene‑1/Metadherin (Review)". Oncology Letters 8, no. 2 (2014): 493-501. https://doi.org/10.3892/ol.2014.2231
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Y and Li LP: Progress of cancer research on astrocyte elevated gene‑1/Metadherin (Review). Oncol Lett 8: 493-501, 2014.
APA
Huang, Y., & Li, L. (2014). Progress of cancer research on astrocyte elevated gene‑1/Metadherin (Review). Oncology Letters, 8, 493-501. https://doi.org/10.3892/ol.2014.2231
MLA
Huang, Y., Li, L."Progress of cancer research on astrocyte elevated gene‑1/Metadherin (Review)". Oncology Letters 8.2 (2014): 493-501.
Chicago
Huang, Y., Li, L."Progress of cancer research on astrocyte elevated gene‑1/Metadherin (Review)". Oncology Letters 8, no. 2 (2014): 493-501. https://doi.org/10.3892/ol.2014.2231
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