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August-2014 Volume 8 Issue 2

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Article

Regulatory effects of miRNA on gastric cancer cells

  • Authors:
    • Ouyang Yang
    • Huang Jianhua
    • Sun Lin
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Xiangya Hospital of Central‑South University, Changsha, Hunan 410008, P.R. China
  • Pages: 651-656
    |
    Published online on: June 5, 2014
       https://doi.org/10.3892/ol.2014.2232
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Abstract

The present study aimed to screen the regulatory mechanism of microRNA (miR/miRNA) typing on gastric cancer cells in gastric cancer tissues. In total, 46 patients who underwent gastric resection in Xiangya Hospital of Central‑South University (Changsha, Hunan, China) between January and December 2012 were selected. Gastric cancer cells were obtained for RNA extraction, and miRNAs were detected by quantitative polymerase chain reaction. Compared with the expression levels in the normal gastric mucosa, the expression levels of miR‑9, miR‑433, miR‑19b and miR‑370 were downregulated; the differences was statistically significant, except for miR‑19b (P<0.05). miRNAs play a regulative role in the occurrence and development of gastric cancer, and changes in their expression provide a basis for the diagnosis of this disease.
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Copy and paste a formatted citation
Spandidos Publications style
Yang O, Jianhua H and Lin S: Regulatory effects of miRNA on gastric cancer cells. Oncol Lett 8: 651-656, 2014.
APA
Yang, O., Jianhua, H., & Lin, S. (2014). Regulatory effects of miRNA on gastric cancer cells. Oncology Letters, 8, 651-656. https://doi.org/10.3892/ol.2014.2232
MLA
Yang, O., Jianhua, H., Lin, S."Regulatory effects of miRNA on gastric cancer cells". Oncology Letters 8.2 (2014): 651-656.
Chicago
Yang, O., Jianhua, H., Lin, S."Regulatory effects of miRNA on gastric cancer cells". Oncology Letters 8, no. 2 (2014): 651-656. https://doi.org/10.3892/ol.2014.2232
Copy and paste a formatted citation
x
Spandidos Publications style
Yang O, Jianhua H and Lin S: Regulatory effects of miRNA on gastric cancer cells. Oncol Lett 8: 651-656, 2014.
APA
Yang, O., Jianhua, H., & Lin, S. (2014). Regulatory effects of miRNA on gastric cancer cells. Oncology Letters, 8, 651-656. https://doi.org/10.3892/ol.2014.2232
MLA
Yang, O., Jianhua, H., Lin, S."Regulatory effects of miRNA on gastric cancer cells". Oncology Letters 8.2 (2014): 651-656.
Chicago
Yang, O., Jianhua, H., Lin, S."Regulatory effects of miRNA on gastric cancer cells". Oncology Letters 8, no. 2 (2014): 651-656. https://doi.org/10.3892/ol.2014.2232
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