Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2014 Volume 8 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2014 Volume 8 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Submucosal small‑cell neuroendocrine carcinoma of the larynx detected using 18F‑fluorodeoxyglucose positron emission tomography/computed tomography: A case report and review of the literature

  • Authors:
    • Hong‑Fang Ying
    • Yang‑Yang Bao
    • Shui‑Hong Zhou
    • Liang Chai
    • Kui Zhao
    • Ting‑Ting Wu
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, The PET Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
  • Pages: 1065-1069
    |
    Published online on: June 12, 2014
       https://doi.org/10.3892/ol.2014.2246
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

A 67‑year‑old male presented with a metastatic carcinoma in the right side of the neck from an unknown primary site. 18F‑fluorodeoxyglucose (FDG) positron emission tomography/computed tomography showed increased 18F‑FDG uptake in the right larynx and right neck lymph nodes. A smooth lesion was identified in the submucosa of the right supraglottic region via a suspension laryngoscopy under general anaesthesia. A biopsy was performed and a frozen section revealed a small‑cell (SC) carcinoma. A total laryngectomy and bilateral neck dissection were performed simultaneously, and the pathological results demonstrated a SC neuroendocrine carcinoma. The patient received chemo‑radiotherapy postoperatively, however, succumbed due to distant metastasis one year following surgery.
View Figures

Figure 1

Figure 2

View References

1 

Spigel DR, Hainsworth JD and Greco FA: Neuroendocrine carcinoma of unknown primary site. Semin Oncol. 36:52–59. 2009.

2 

Hess KR, Abbruzzese MC, Lenzi R, Raber MN and Abbruzzese JL: Classification and regression tree analysis of 1000 consecutive patients with unknown primary carcinoma. Clin Cancer Res. 5:3403–3410. 1999.

3 

Lee HS, Han HS, Lim SN, et al: Poorly differentiated neuroendocrine carcinoma in a perigastric lymph node from an unknown primary site. Cancer Res Treat. 44:271–274. 2012.

4 

Kim HY, Choi SI and Kim YH: Neuroendocrine tumor of unknown primary accompanied with stomach adenocarcinoma. J Gastric Cancer. 11:234–238. 2011.

5 

Naswa N, Sharma P, Kumar A, et al: 68Ga-DOTANOC PET/CT in patients with carcinoma of unknown primary of neuroendocrine origin. Clin Nucl Med. 37:245–251. 2012.

6 

Miki K, Orita Y, Nose S, et al: Neuroendocrine carcinoma of the larynx presenting as a primary unknown carcinoma. Auris Nasus Larynx. 39:98–102. 2012.

7 

de Bree R: The real additional value of FDG-PET in detecting the occult primary tumour in patients with cervical lymph node metastases of unknown primary tumour. Eur Arch Otorhinolaryngol. 267:1653–1655. 2010.

8 

Deron PB, Bonte KM, Vermeersch HF and Van de Wiele C: Lymph node metastasis of squamous cell carcinoma from an unknown primary in the upper and middle neck: Impact of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography. Cancer Biother Radiopharm. 26:331–334. 2011.

9 

Zhao K, Luo XM, Zhou SH, et al: 18F-fluorodeoxyglucose positron emission tomography/computed tomography as an effective diagnostic workup in cervical metastasis of carcinoma from an unknown primary tumor. Cancer Biother Radiopharm. 27:685–693. 2012.

10 

Prasad V, Ambrosini V, Hommann M, Hoersch D, Fanti S and Baum RP: Detection of unknown primary neuroendocrine tumours (CUP-NET) using (68)Ga-DOTA-NOC receptor PET/CT. Eur J Nucl Med Mol Imaging. 37:67–77. 2010.

11 

Sobin LH and Wittekind CH: International Union Against Cancer (UICC). TNM classification of malignant tumours. 5th edition. Wiley-Liss; New York, NY: pp. 3361997

12 

Stoyianni A, Pentheroudakis G and Pavlidis N: Neuroendocrine carcinoma of unknown primary: a systematic review of the literature and a comparative study with other neuroendocrine tumors. Cancer Treat Rev. 37:358–365. 2011.

13 

Ferlito A, Silver CE, Bradford CR and Rinaldo A: Neuroendocrine neoplasms of the larynx: an overview. Head Neck. 31:1634–1646. 2009.

14 

Mikić A, Zvrko E, Trivić A, Stefanović D and Golubović M: Small cell neuroendocrine tumor of the larynx - a small case series. Coll Antropol. 36(Suppl 2): 201–204. 2012.

15 

Møller AK, Loft A, Berthelsen AK, et al: A prospective comparison of 18F-FDG PET/CT and CT as diagnostic tools to identify the primary tumor site in patients with extracervical carcinoma of unknown primary site. Oncologist. 17:1146–1154. 2012.

16 

Adams S, Baum R, Rink T, Schumm-Dräger PM, Usadel KH and Hör G: Limited value of fluorine-18 fluorodeoxyglucose positron emission tomography for the imaging of neuroendocrine tumours. Eur J Nucl Med. 25:79–83. 1998.

17 

Song YS, Lee WW, Chung JH, Park SY, Kim YK and Kim SE: Correlation between FDG uptake and glucose transporter type 1 expression in neuroendocrine tumors of the lung. Lung Cancer. 61:54–60. 2008.

18 

Chen XH, Bao YY, Zhou SH, Wang QY and Zhao K: Palatine tonsillar metastasis of small-cell neuroendocrine carcinoma from the lung detected by FDG-PET/CT after tonsillectomy: A case report. Iran J Radiol. 10:148–151. 2013.

19 

Ozpacaci T, Tamam MO, Mulazimoglu M, Kamali G and Ozcan D: Isolated adrenal metastasis of small cell neuroendocrine carcinoma of the ovary detected with FDG-PET/CT. Rev Esp Med Nucl Imagen Mol. 31:297–298. 2012.

20 

Treglia G, Salomone E, Petrone G, Giaccari A, Rindi G and Rufini V: A rare case of ectopic adrenocorticotropic hormone syndrome caused by a metastatic neuroendocrine tumor of the pancreas detected by 68Ga-DOTANOC and 18F-FDG PET/CT. Clin Nucl Med. 38:e306–e308. 2013.

21 

Treglia G, Plastino F and Campitiello M: Staging and treatment response evaluation in a metastatic neuroendocrine tumor of the pancreas with G2 grading: insights from multimodality diagnostic approach by F-18-FDG and Ga-68-DOTANOC PET/CT. Endocrine. 43:729–731. 2013.

22 

Liu Y: FDG PET-CT demonstration of metastatic neuroendocrine tumor of prostate. World J Surg Oncol. 6:642008.

23 

Kim HJ and Hwang EG: Small cell carcinoma of the larynx: imaging findings. Auris Nasus Larynx. 24:423–427. 1997.

24 

Ferlito A and Rinaldo A: Primary and secondary small cell neuroendocrine carcinoma of the larynx: a review. Head Neck. 30:518–524. 2008.

25 

Baugh RF, Wolf GT, Beals TF, Krause CJ and Forastiere A: Small cell carcinoma of the larynx: results of therapy. Laryngoscope. 96:1283–1290. 1986.

26 

Ferlito A, Pesavento G, Recher G, et al: Long-term survival in response to combined chemotherapy and radiotherapy in laryngeal small cell carcinoma. Auris Nasus Larynx. 13:113–123. 1986.

27 

Brennan SM, Gregory DL, Stillie A, Herschtal A, Mac Manus M and Ball DL: Should extrapulmonary small cell cancer be managed like small cell lung cancer? Cancer. 116:888–895. 2010.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ying HF, Bao YY, Zhou SH, Chai L, Zhao K and Wu TT: Submucosal small‑cell neuroendocrine carcinoma of the larynx detected using 18F‑fluorodeoxyglucose positron emission tomography/computed tomography: A case report and review of the literature. Oncol Lett 8: 1065-1069, 2014.
APA
Ying, H., Bao, Y., Zhou, S., Chai, L., Zhao, K., & Wu, T. (2014). Submucosal small‑cell neuroendocrine carcinoma of the larynx detected using 18F‑fluorodeoxyglucose positron emission tomography/computed tomography: A case report and review of the literature. Oncology Letters, 8, 1065-1069. https://doi.org/10.3892/ol.2014.2246
MLA
Ying, H., Bao, Y., Zhou, S., Chai, L., Zhao, K., Wu, T."Submucosal small‑cell neuroendocrine carcinoma of the larynx detected using 18F‑fluorodeoxyglucose positron emission tomography/computed tomography: A case report and review of the literature". Oncology Letters 8.3 (2014): 1065-1069.
Chicago
Ying, H., Bao, Y., Zhou, S., Chai, L., Zhao, K., Wu, T."Submucosal small‑cell neuroendocrine carcinoma of the larynx detected using 18F‑fluorodeoxyglucose positron emission tomography/computed tomography: A case report and review of the literature". Oncology Letters 8, no. 3 (2014): 1065-1069. https://doi.org/10.3892/ol.2014.2246
Copy and paste a formatted citation
x
Spandidos Publications style
Ying HF, Bao YY, Zhou SH, Chai L, Zhao K and Wu TT: Submucosal small‑cell neuroendocrine carcinoma of the larynx detected using 18F‑fluorodeoxyglucose positron emission tomography/computed tomography: A case report and review of the literature. Oncol Lett 8: 1065-1069, 2014.
APA
Ying, H., Bao, Y., Zhou, S., Chai, L., Zhao, K., & Wu, T. (2014). Submucosal small‑cell neuroendocrine carcinoma of the larynx detected using 18F‑fluorodeoxyglucose positron emission tomography/computed tomography: A case report and review of the literature. Oncology Letters, 8, 1065-1069. https://doi.org/10.3892/ol.2014.2246
MLA
Ying, H., Bao, Y., Zhou, S., Chai, L., Zhao, K., Wu, T."Submucosal small‑cell neuroendocrine carcinoma of the larynx detected using 18F‑fluorodeoxyglucose positron emission tomography/computed tomography: A case report and review of the literature". Oncology Letters 8.3 (2014): 1065-1069.
Chicago
Ying, H., Bao, Y., Zhou, S., Chai, L., Zhao, K., Wu, T."Submucosal small‑cell neuroendocrine carcinoma of the larynx detected using 18F‑fluorodeoxyglucose positron emission tomography/computed tomography: A case report and review of the literature". Oncology Letters 8, no. 3 (2014): 1065-1069. https://doi.org/10.3892/ol.2014.2246
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team