Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2014 Volume 8 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2014 Volume 8 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association between four common microRNA polymorphisms and the risk of hepatocellular carcinoma and HBV infection

  • Authors:
    • Jian‑Tao Kou
    • Hua Fan
    • Dongdong Han
    • Lixin Li
    • Ping Li
    • Jiqiao Zhu
    • Jun Ma
    • Zhi‑Hua Zhang
    • Qiang He
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China
  • Pages: 1255-1260
    |
    Published online on: June 16, 2014
       https://doi.org/10.3892/ol.2014.2257
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

microRNAs (miR/miRNAs) have been demonstrated to function as tumor suppressors and oncogenes, and miRNA polymorphisms may have a role in cancer development. The present study aimed to investigate the association between the miR‑146aG>C, miR‑149C>T, miR‑196a2C>T and miR‑499A>G polymorphisms and the risk of hepatocellular carcinoma (HCC) and hepatitis B virus (HBV) infection. A total of 271 patients with HCC and 532 healthy control participants were enrolled in the present study. miR‑146aG>C, miR‑149C>T, miR‑196a2C>T and miR‑499A>G polymorphisms were genotyped using the polymerase chain reaction‑restriction fragment length polymorphism method. A significant difference was identified in the genotype frequency of miR‑196a2C>T in the patients in the case group compared with the control group (χ2=6.88; P=0.032). Compared with the CC genotype, the miR‑196a2 TT genotype was associated with a significantly reduced risk of HCC [odds ratio (OR), 0.62; 95% confidence interval (CI), 0.38‑0.99], and a significantly reduced risk was also found in the dominant (OR, 0.69; 95% CI, 0.49‑0.98) and recessive (OR, 0.70; 95% CI, 0.46‑1.02) models. Moreover, individuals with HBV who were carrying the miR‑196a2 CT and TT genotypes had a significantly reduced risk of HCC (OR, 0.62; 95% CI, 0.41‑0.95; and OR, 0.39; 95% CI, 0.20‑0.73, respectively). In conclusion, the present study found that the miR‑196a2C>T polymorphism has a protective effect in patients with HCC, particularly in those with HBV infection.
View Figures
View References

1 

International Agency for Research on Cancer. 2012, Liver Cancer. Estimated Incidence, Mortality and Prevalence Worldwide in 2012. http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx. Accessed January 1, 2014

2 

Yu MC and Yuan JM: Environmental factors and risk for hepatocellular carcinoma. Gastroenterology. 127(5 Suppl 1): S72–S78. 2004.

3 

Davila JA, Morgan RO, Shaib Y, McGlynn KA and El-Serag HB: Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: a population-based study. Gastroenterology. 127:1372–1380. 2004.

4 

Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004.

5 

Valencia-Sanchez MA, Liu J, Hannon GJ, et al: Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 20:515–524. 2006.

6 

Lim LP, Lau NC, Garrett-Engele P, et al: Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 433:769–773. 2005.

7 

Wilfred BR, Wang WX and Nelson PT: Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways. Mol Genet Metab. 91:209–217. 2007.

8 

Pizzini S, Bisognin A, Mandruzzato S, et al: Impact of microRNAs on regulatory networks and pathways in human colorectal carcinogenesis and development of metastasis. BMC Genomics. 14:5892013.

9 

Sung SY, Liao CH, Wu HP, et al: Loss of let-7 microRNA upregulates IL-6 in bone marrow-derived mesenchymal stem cells triggering a reactive stromal response to prostate cancer. PLoS One. 8:e716372013.

10 

Saito K, Inagaki K, Kamimoto T, et al: MicroRNA-196a is a putative diagnostic biomarker and therapeutic target for laryngeal cancer. PLoS One. 8:e714802013.

11 

He B, Pan Y, Cho WC, et al: The association between four genetic variants in microRNAs (rs11614913, rs2910164, rs3746444, rs2292832) and cancer risk: evidence from published studies. PLoS One. 7:e490322012.

12 

Hu Z, Liang J, Wang Z, et al: Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women. Hum Mutat. 30:79–84. 2009.

13 

Lee HC, Kim JG, Chae YS, et al: Prognostic impact of microRNA-related gene polymorphisms on survival of patients with colorectal cancer. J Cancer Res Clin Oncol. 136:1073–1078. 2010.

14 

Peng S, Kuang Z, Sheng C, et al: Association of microRNA-196a-2 gene polymorphism with gastric cancer risk in a Chinese population. Dig Dis Sci. 55:2288–2293. 2010.

15 

Qi P, Dou TH, Geng L, Zhou FG, Gu X, Wang H and Gao CF: Association of a variant in MIR 196A2 with susceptibility to hepatocellular carcinoma in male Chinese patients with chronic hepatitis B virus infection. Hum Immunol. 71:621–626. 2010.

16 

Li XD, Li ZG, Song XX and Liu CF: A variant in microRNA-196a2 is associated with susceptibility to hepatocellular carcinoma in Chinese patients with cirrhosis. Pathology. 42:669–673. 2010.

17 

Xiang Y, Fan S, Cao J, et al: Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population. Mol Biol Rep. 39:7019–7023. 2012.

18 

Kim WH, Min KT, Jeon YJ, et al: Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population. Gene. 504:92–97. 2012.

19 

Hu M, Zhao L, Hu S and Yang J: The association between two common polymorphisms in MicroRNAs and hepatocellular carcinoma risk in Asian population. PLoS One. 8:e570122013.

20 

Zheng SQ, Li YX, Zhang Y, et al: MiR-101 regulates HSV-1 replication by targeting ATP5B. Antiviral Res. 89:219–226. 2011.

21 

Cui C, Griffiths A, Li G, et al: Prediction and identification of herpes simplex virus 1-encoded microRNAs. J Virol. 80:5499–5508. 2006.

22 

Esquela-Kerscher A and Slack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006.

23 

Spaniel C, Honda M, Selitsky SR, et al: microRNA-122 abundance in hepatocellular carcinoma and non-tumor liver tissue from Japanese patients with persistent HCV versus HBV infection. PLoS One. 8:e768672013.

24 

Ma Y, Wang R, Zhang J, et al: Identification of miR-423 and miR-499 polymorphisms on affecting the risk of hepatocellular carcinoma in a large-scale population. Genet Test Mol Biomarkers. May 22–2014.

25 

Kim HY, Yoon JH, Lee HS, et al: MicroRNA-196A-2 polymorphisms and hepatocellular carcinoma in patients with chronic hepatitis B. J Med Virol. 86:446–453. 2014.

26 

Wu M, Jolicoeur N, Li Z, et al: Genetic variations of microRNAs in human cancer and their effects on the expression of miRNAs. Carcinogenesis. 29:1710–1716. 2008.

27 

Zhang M, Jin M, Yu Y, et al: Associations of miRNA polymorphisms and female physiological characteristics with breast cancer risk in Chinese population. Eur J Cancer Care (Engl). 21:274–280. 2012.

28 

Wang F, Sun GP, Zou YF, Fan LL and Song B: Quantitative assessment of the association between miR-196a2 rs11614913 polymorphism and gastrointestinal cancer risk. Mol Biol Rep. 40:109–116. 2013.

29 

Hezova R, Kovarikova A, Bienertova-Vasku J, et al: Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer. World J Gastroenterol. 18:2827–2831. 2012.

30 

Pavlakis E, Papaconstantinou I, Gazouli M, et al: MicroRNA gene polymorphisms in pancreatic cancer. Pancreatology. 13:273–278. 2013.

31 

Wei J, Zheng L, Liu S, et al: MiR-196a2 rs11614913 T>C polymorphism and risk of esophageal cancer in a Chinese population. Hum Immunol. 74:1199–1205. 2013.

32 

Yuan Z, Zeng X, Yang D, Wang W and Liu Z: Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk. PLoS One. 8:e610472013.

33 

Hao YX, Wang JP and Zhao LF: Associations between three common MicroRNA polymorphisms and hepatocellular carcinoma risk in Chinese. Asian Pac J Cancer Prev. 14:6601–6604. 2013.

34 

Han Y, Pu R, Han X, et al: Associations of pri-miR-34b/c and pre-miR-196a2 polymorphisms and their multiplicative interactions with hepatitis B virus mutations with hepatocellular carcinoma risk. PLoS One. 8:e585642013.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kou JT, Fan H, Han D, Li L, Li P, Zhu J, Ma J, Zhang ZH and He Q: Association between four common microRNA polymorphisms and the risk of hepatocellular carcinoma and HBV infection. Oncol Lett 8: 1255-1260, 2014.
APA
Kou, J., Fan, H., Han, D., Li, L., Li, P., Zhu, J. ... He, Q. (2014). Association between four common microRNA polymorphisms and the risk of hepatocellular carcinoma and HBV infection. Oncology Letters, 8, 1255-1260. https://doi.org/10.3892/ol.2014.2257
MLA
Kou, J., Fan, H., Han, D., Li, L., Li, P., Zhu, J., Ma, J., Zhang, Z., He, Q."Association between four common microRNA polymorphisms and the risk of hepatocellular carcinoma and HBV infection". Oncology Letters 8.3 (2014): 1255-1260.
Chicago
Kou, J., Fan, H., Han, D., Li, L., Li, P., Zhu, J., Ma, J., Zhang, Z., He, Q."Association between four common microRNA polymorphisms and the risk of hepatocellular carcinoma and HBV infection". Oncology Letters 8, no. 3 (2014): 1255-1260. https://doi.org/10.3892/ol.2014.2257
Copy and paste a formatted citation
x
Spandidos Publications style
Kou JT, Fan H, Han D, Li L, Li P, Zhu J, Ma J, Zhang ZH and He Q: Association between four common microRNA polymorphisms and the risk of hepatocellular carcinoma and HBV infection. Oncol Lett 8: 1255-1260, 2014.
APA
Kou, J., Fan, H., Han, D., Li, L., Li, P., Zhu, J. ... He, Q. (2014). Association between four common microRNA polymorphisms and the risk of hepatocellular carcinoma and HBV infection. Oncology Letters, 8, 1255-1260. https://doi.org/10.3892/ol.2014.2257
MLA
Kou, J., Fan, H., Han, D., Li, L., Li, P., Zhu, J., Ma, J., Zhang, Z., He, Q."Association between four common microRNA polymorphisms and the risk of hepatocellular carcinoma and HBV infection". Oncology Letters 8.3 (2014): 1255-1260.
Chicago
Kou, J., Fan, H., Han, D., Li, L., Li, P., Zhu, J., Ma, J., Zhang, Z., He, Q."Association between four common microRNA polymorphisms and the risk of hepatocellular carcinoma and HBV infection". Oncology Letters 8, no. 3 (2014): 1255-1260. https://doi.org/10.3892/ol.2014.2257
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team