Metaplastic breast carcinoma development following surgical resection of an inflammatory myofibroblastic tumor in the right breast: A case report
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- Published online on: June 17, 2014 https://doi.org/10.3892/ol.2014.2261
- Pages: 1345-1347
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Abstract
Inflammatory myofibroblastic tumors (IMTs) are uncommon, mesenchymal lesions, and malignant transformation is extremely rare. The current study presents the case of a 56‑year‑old female with a rapidly growing mass in the right breast, which was diagnosed as IMT. Immunohistochemically, the mass was positive for smooth muscle actin (SMA) and Ki‑67 (positive staining in 30% of the cells), and negative for S‑100, cluster of differentiation (CD)34, p63 and cytokeratin. Malignant transformation to metaplastic carcinoma of the spindle‑cell type was observed following surgical resection. This metaplastic carcinoma demonstrated positive immunoreactivity for cytokeratin, vimentin, CD34, p63 and Ki‑67 (>30%), and was negative for cytokeratin 7, SMA, desmin and S‑100. The patient underwent total mastectomy of the right breast, followed by palliative chemotherapy with capecitabine; however, the patient succumbed to the disease after 12 weeks. The unusual case presented in the current study emphasizes the importance of pre‑operative examinations to determine the benign or malignant nature of IMTs, which aids in the choice of appropriate surgical procedures.
