Metaplastic breast carcinoma development following surgical resection of an inflammatory myofibroblastic tumor in the right breast: A case report

Xing,Peng; Li,Jiguang; Jin,Feng; Wu,Yunfei; Zheng,Xinyu; Chen,Bo; Yao,Fan; Wei,Xiaolin

doi:10.3892/ol.2014.2261

September-2014 Volume 8 Issue 3

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

September-2014 Volume 8 Issue 3

Full Size Image

Case Report

Metaplastic breast carcinoma development following surgical resection of an inflammatory myofibroblastic tumor in the right breast: A case report

Authors:
- Peng Xing
- Jiguang Li
- Feng Jin
- Yunfei Wu
- Xinyu Zheng
- Bo Chen
- Fan Yao
- Xiaolin Wei
View Affiliations / Copyright

Affiliations: Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
Pages: 1345-1347
|
Published online on: June 17, 2014

https://doi.org/10.3892/ol.2014.2261
Expand metrics +

Abstract

Inflammatory myofibroblastic tumors (IMTs) are uncommon, mesenchymal lesions, and malignant transformation is extremely rare. The current study presents the case of a 56‑year‑old female with a rapidly growing mass in the right breast, which was diagnosed as IMT. Immunohistochemically, the mass was positive for smooth muscle actin (SMA) and Ki‑67 (positive staining in 30% of the cells), and negative for S‑100, cluster of differentiation (CD)34, p63 and cytokeratin. Malignant transformation to metaplastic carcinoma of the spindle‑cell type was observed following surgical resection. This metaplastic carcinoma demonstrated positive immunoreactivity for cytokeratin, vimentin, CD34, p63 and Ki‑67 (>30%), and was negative for cytokeratin 7, SMA, desmin and S‑100. The patient underwent total mastectomy of the right breast, followed by palliative chemotherapy with capecitabine; however, the patient succumbed to the disease after 12 weeks. The unusual case presented in the current study emphasizes the importance of pre‑operative examinations to determine the benign or malignant nature of IMTs, which aids in the choice of appropriate surgical procedures.

View Figures

View References

1	Saab ST, Hornick JL, Fletcher CD, Olson SJ and Coffin CM: IgG4 plasma cells in inflammatory myofibroblastic tumor: inflammatory marker or pathogenic link? Mod Pathol. 24:606–612. 2011.
2	Jain A, Kasana S, Ramrakhiani D and Sharma M: Inflammatory myofibroblastic tumor of the stomach in an adult female - report of a rare case and review of the literature. Turk J Gastroenterol. 23:399–405. 2012.
3	Gleason BC and Hornick JL: Inflammatory myofibroblastic tumours: where are we now? J Clin Pathol. 61:428–437. 2008.
4	Carillo C, Anile M, De Giacomo T and Venuta F: Bilateral simultaneous inflammatory myofibroblastic tumor of the lung with distant metastatic spread. Interact Cardiovasc Thorac Surg. 13:246–247. 2011.
5	Kovach SJ, Fischer AC, Katzman PJ, Salloum RM, Ettinghausen SE, Madeb R and Koniaris LG: Inflammatory myofibroblastic tumors. J Surg Oncol. 94:385–391. 2006.
6	Chavez C and Hoffman MA: Complete remission of ALK-negative plasma cell granuloma (inflammatory myofibroblastic tumor) of the lung induced by celecoxib: A case report and review of the literature. Oncol Lett. 5:1672–1676. 2013.
7	Zhao HD, Wu T, Wang JQ, et al: Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis: A case report. Oncol Lett. 5:97–100. 2013.
8	Khanafshar E, Phillipson J, Schammel DP, Minobe L, Cymerman J and Weidner N: Inflammatory myofibroblastic tumor of the breast. Ann Diagn Pathol. 9:123–129. 2005.
9	Idrees MT, Huan Y, Woo P and Wang BY: Inflammatory myofibroblastic tumor of larynx: a benign lesion with variable morphological spectrum. Ann Diagn Pathol. 11:433–439. 2007.
10	Ezzine-Baccari S, Bacha D and Sassi S, Abouda M, Ghrairi H, Touinsi H and Sassi S: Inflammatory myofibroblastic tumor of the lung: a benign lesion with aggressive behavior. Gen Thorac Cardiovasc Surg. 60:531–533. 2012.
11	Fletcher CD, Unni KK and Mertens F: World Health Organization Classification of Tumors. Pathology and Genetics of Soft Tissue and Bone. IARC Press; Lyon: pp. 91–93. 2002
12	Melloni G, Carretta A, Ciriaco P, et al: Inflammatory pseudotumor of the lung in adults. Ann Thorac Surg. 79:426–432. 2005.
13	Obeid E, Nanda R, Fu YX and Olopade OI: The role of tumor-associated macrophages in breast cancer progression (Review). Int J Oncol. 43:5–12. 2013.
14	Nielsen JS and McNagny KM: Novel functions of the CD34 family. J Cell Sci. 121:3683–3692. 2008.
15	Stefanou D, Batistatou A, Nonni A, Arkoumani E and Agnantis NJ: p63 expression in benign and malignant breast lesions. Histol Histopathol. 19:465–471. 2004.
16	Brotherick I, Robson CN, Browell DA, et al: Cytokeratin expression in breast cancer: phenotypic changes associated with disease progression. Cytometry. 32:301–308. 1998.
17	Negm H, Mosleh M, Fathy H, Hareedy A and Elbattawy A: Cytokeratin immunohistochemically detected nodal micrometastases in N0 laryngeal cancer: impact on the overall occult metastases. Eur Arch Otorhinolaryngol. 270:1085–1092. 2013.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Metaplastic breast carcinoma development following surgical resection of an inflammatory myofibroblastic tumor in the right breast: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles