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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September-2014 Volume 8 Issue 3

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Article

B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malignancy grade of glioma patients

  • Authors:
    • Aparajita Baral
    • Hong Xing Ye
    • Pu Cha Jiang
    • Yu Yao
    • Ying Mao
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China
  • Pages: 1195-1201
    |
    Published online on: June 19, 2014
       https://doi.org/10.3892/ol.2014.2268
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Abstract

The B7 family consists of activating and inhibitory molecules that regulate immune responses. Recent research demonstrated the roles of soluble B7‑H3 (sB7‑H3) and soluble B7‑H1 (sB7‑H1) in the blood serum of various tumors; however, none of these studies investigated the expression of these proteins in the cerebral spinal fluid (CSF) and blood serum of patients with glioma. The aim of the present study was to investigate the expression of B7‑H3 and B7‑H1 in the CSF, blood serum and tissues of patients with glioma and their correlation with clinicopathological data. Between January 2012 and November 2012, samples were obtained from 78 patients with glioma, four CSF samples were obtained from patients with a moderate traumatic brain injury, four brain tissue samples were obtained from patients with a traumatic brain injury and 40 blood serum samples were obtained from healthy individuals. The expression of B7-H3 and B7-H1 in the CSF, blood serum and tumor samples of the patients with high‑grade glioma was found to be higher than that in the patients with low‑grade glioma. However, no significant differences in sB7‑H3 and sB7‑H1 expression were observed in the blood serum of the patients with glioma compared with the healthy control subjects. In addition, the expression of sB7‑H3 and sB7‑H1 in the CSF of the patients with glioma was higher than that in the CSF of the patients with a moderate traumatic brain injury. Furthermore, in the patients with glioma, B7‑H3 and B7‑H1 expression in the CSF and tumor tissue, although not in the blood serum, correlated with the glioma grade.
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Copy and paste a formatted citation
Spandidos Publications style
Baral A, Ye HX, Jiang PC, Yao Y and Mao Y: B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malignancy grade of glioma patients. Oncol Lett 8: 1195-1201, 2014.
APA
Baral, A., Ye, H.X., Jiang, P.C., Yao, Y., & Mao, Y. (2014). B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malignancy grade of glioma patients. Oncology Letters, 8, 1195-1201. https://doi.org/10.3892/ol.2014.2268
MLA
Baral, A., Ye, H. X., Jiang, P. C., Yao, Y., Mao, Y."B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malignancy grade of glioma patients". Oncology Letters 8.3 (2014): 1195-1201.
Chicago
Baral, A., Ye, H. X., Jiang, P. C., Yao, Y., Mao, Y."B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malignancy grade of glioma patients". Oncology Letters 8, no. 3 (2014): 1195-1201. https://doi.org/10.3892/ol.2014.2268
Copy and paste a formatted citation
x
Spandidos Publications style
Baral A, Ye HX, Jiang PC, Yao Y and Mao Y: B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malignancy grade of glioma patients. Oncol Lett 8: 1195-1201, 2014.
APA
Baral, A., Ye, H.X., Jiang, P.C., Yao, Y., & Mao, Y. (2014). B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malignancy grade of glioma patients. Oncology Letters, 8, 1195-1201. https://doi.org/10.3892/ol.2014.2268
MLA
Baral, A., Ye, H. X., Jiang, P. C., Yao, Y., Mao, Y."B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malignancy grade of glioma patients". Oncology Letters 8.3 (2014): 1195-1201.
Chicago
Baral, A., Ye, H. X., Jiang, P. C., Yao, Y., Mao, Y."B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malignancy grade of glioma patients". Oncology Letters 8, no. 3 (2014): 1195-1201. https://doi.org/10.3892/ol.2014.2268
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