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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September-2014 Volume 8 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Case Report

High efficacy of gefitinib in the treatment of EGFR mutation‑positive advanced non‑small cell lung adenocarcinoma: A case report

  • Authors:
    • Zhongchao Wang
    • Jianjun Chu
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy, Xinyi People's Hospital, Xuzhou, Jiangsu 221400, P.R. China, Department of Radiotherapy, The Fourth Affiliated Hospital of Soochow University, Wuxi, Jiangsu 214062, P.R. China
  • Pages: 1320-1322
    |
    Published online on: June 19, 2014
       https://doi.org/10.3892/ol.2014.2269
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Abstract

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib, are known to play a significant role in EGFR mutation‑positive non‑small cell lung cancer. When an EGFR mutation is found, gefitinib and erlotinib have been shown to have significant roles in the treatment of untreated advanced NSCLC. This study reports an EGFR mutation in NSCLC treated with gefitinib and is notable due to the patient's marked improvement following a shorter than average duration of treatment with gefitinib. The present study reports the case of a 58‑year‑old male smoker with a dry cough. Computed tomography revealed a mass in the left inferior lobe of the lung. The patient was subsequently diagnosed with advanced lung adenocarcinoma, and an EGFR mutation (in‑frame deletions of E746-A750 in exon 19) was found. The patient received multiple rounds of chemotherapy, followed by gefitinib maintenance therapy for 3 months. Later on, a grade 1 acne‑like rash developed on the face and back that lasted throughout the treatment. Currently, the patient is stable, with no evidence of disease progression. The present study describes the disease and the treatment using gefitinib.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Z and Chu J: High efficacy of gefitinib in the treatment of EGFR mutation‑positive advanced non‑small cell lung adenocarcinoma: A case report. Oncol Lett 8: 1320-1322, 2014.
APA
Wang, Z., & Chu, J. (2014). High efficacy of gefitinib in the treatment of EGFR mutation‑positive advanced non‑small cell lung adenocarcinoma: A case report. Oncology Letters, 8, 1320-1322. https://doi.org/10.3892/ol.2014.2269
MLA
Wang, Z., Chu, J."High efficacy of gefitinib in the treatment of EGFR mutation‑positive advanced non‑small cell lung adenocarcinoma: A case report". Oncology Letters 8.3 (2014): 1320-1322.
Chicago
Wang, Z., Chu, J."High efficacy of gefitinib in the treatment of EGFR mutation‑positive advanced non‑small cell lung adenocarcinoma: A case report". Oncology Letters 8, no. 3 (2014): 1320-1322. https://doi.org/10.3892/ol.2014.2269
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Z and Chu J: High efficacy of gefitinib in the treatment of EGFR mutation‑positive advanced non‑small cell lung adenocarcinoma: A case report. Oncol Lett 8: 1320-1322, 2014.
APA
Wang, Z., & Chu, J. (2014). High efficacy of gefitinib in the treatment of EGFR mutation‑positive advanced non‑small cell lung adenocarcinoma: A case report. Oncology Letters, 8, 1320-1322. https://doi.org/10.3892/ol.2014.2269
MLA
Wang, Z., Chu, J."High efficacy of gefitinib in the treatment of EGFR mutation‑positive advanced non‑small cell lung adenocarcinoma: A case report". Oncology Letters 8.3 (2014): 1320-1322.
Chicago
Wang, Z., Chu, J."High efficacy of gefitinib in the treatment of EGFR mutation‑positive advanced non‑small cell lung adenocarcinoma: A case report". Oncology Letters 8, no. 3 (2014): 1320-1322. https://doi.org/10.3892/ol.2014.2269
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